Search Results - "VAKKALANKA, Radhakrishna"

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy by Law, Amanda J, Wang, Yanhong, Sei, Yoshitatsu, O’Donnell, Patricio, Piantadosi, Patrick, Papaleo, Francesco, Straub, Richard E, Huang, Wenwei, Thomas, Craig J, Vakkalanka, Radhakrishna, Besterman, Aaron D, Lipska, Barbara K, Hyde, Thomas M, Harrison, Paul J, Kleinman, Joel E, Weinberger, Daniel R

“…Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a…”
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DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms by Nakata, Kenji, Lipska, Barbara K, Hyde, Thomas M, Ye, Tianzhang, Newburn, Erin N, Morita, Yukitaka, Vakkalanka, Radhakrishna, Barenboim, Maxim, Sei, Yoshitatsu, Weinberger, Daniel R, Kleinman, Joel E

“…Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown. We…”
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Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia by Weickert, Cynthia Shannon, Miranda-Angulo, Ana L., Wong, Jenny, Perlman, William R., Ward, Sarah E., Radhakrishna, Vakkalanka, Straub, Richard E., Weinberger, Daniel R., Kleinman, Joel E.

“…Estrogen modifies human emotion and cognition and impacts symptoms of schizophrenia. We hypothesized that the variation in the estrogen receptor alpha (ESR1)…”
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Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1 : influence on risk of schizophrenia by NICODEMUS, Kristin K, KOLACHANA, Bhaskar S, VAKKALANKA, Radhakrishna, STRAUB, Richard E, GIEGLING, Ina, EGAN, Michael F, RUJESCU, Dan, WEINBERGER, Daniel R

“…Catechol-O-methyltransferase (COMT) regulates dopamine degradation and is located in a genomic region that is deleted in a syndrome associated with psychosis,…”
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Effects of neuregulin 3 genotype on human prefrontal cortex physiology by Tost, Heike, Callicott, Joseph H, Rasetti, Roberta, Vakkalanka, Radhakrishna, Mattay, Venkata S, Weinberger, Daniel R, Law, Amanda J

“…The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia. Specifically, the T allele…”
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Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function by Kempf, Lucas, Nicodemus, Kristin K, Kolachana, Bhaskar, Vakkalanka, Radhakrishna, Verchinski, Beth A, Egan, Michael F, Straub, Richard E, Mattay, Venkata A, Callicott, Joseph H, Weinberger, Daniel R, Meyer-Lindenberg, Andreas

“…PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial…”
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Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness by Bigos, Kristin L, Mattay, Venkata S, Callicott, Joseph H, Straub, Richard E, Vakkalanka, Radhakrishna, Kolachana, Bhaskar, Hyde, Thomas M, Lipska, Barbara K, Kleinman, Joel E, Weinberger, Daniel R

“…CONTEXT The CACNA1C gene (α-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia,…”
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Incomplete penetrance of NRXN1 deletions in families with schizophrenia by Todarello, Giovanna, Feng, Ningping, Kolachana, Bhaskar S, Li, Chao, Vakkalanka, Radhakrishna, Bertolino, Alessandro, Weinberger, Daniel R, Straub, Richard E

“…Abstract Neurexin 1 (NRXN1) is a presynaptic neuronal adhesion molecule that interacts with postsynaptic neuroligins in both glutamatergic and GABAergic…”
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Risk for Premenstrual Dysphoric Disorder Is Associated with Genetic Variation in ESR1, the Estrogen Receptor Alpha Gene by Huo, Liang, Straub, Richard E, Roca, Catherine, Schmidt, Peter J, Shi, Kai, Vakkalanka, Radhakrishna, Weinberger, Daniel R, Rubinow, David R

“…Background Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible…”
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Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging by Nicodemus, Kristin K, Callicott, Joseph H, Higier, Rachel G, Luna, Augustin, Nixon, Devon C, Lipska, Barbara K, Vakkalanka, Radhakrishna, Giegling, Ina, Rujescu, Dan, Clair, David St, Muglia, Pierandrea, Shugart, Yin Yao, Weinberger, Daniel R

“…The etiology of schizophrenia likely involves genetic interactions. DISC1, a promising candidate susceptibility gene, encodes a protein which interacts with…”
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Evidence of Sex-Modulated Association of ZNF804A with Schizophrenia by Zhang, Fengyu, Chen, Qiang, Ye, Tianzhang, Lipska, Barbara K, Straub, Richard E, Vakkalanka, Radhakrishna, Rujescu, Dan, St. Clair, David, Hyde, Thomas M, Bigelow, Llewellyn, Kleinman, Joel E, Weinberger, Daniel R

“…Background The single nucleotide polymorphism (SNP) rs1344706 in ZNF804A (2q32.1) has been associated with schizophrenia in a genome-wide association study…”
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Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia by Mitkus, Shruti N, Hyde, Thomas M, Vakkalanka, Radhakrishna, Kolachana, Bhaskar, Weinberger, Daniel R, Kleinman, Joel E, Lipska, Barbara K

“…Abstract Prior studies have found decreased mRNA expression of oligodendrocyte-associated genes in the dorsolateral prefrontal cortex (DLPFC) of patients with…”
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Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs by Lipska, Barbara K., Peters, Tricia, Hyde, Thomas M., Halim, Nader, Horowitz, Cara, Mitkus, Shruti, Weickert, Cynthia Shannon, Matsumoto, Mitsuyuki, Sawa, Akira, Straub, Richard E., Vakkalanka, Radhakrishna, Herman, Mary M., Weinberger, Daniel R., Kleinman, Joel E.

“…DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs…”
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Allelic Variation in RGS4 Impacts Functional and Structural Connectivity in the Human Brain by Buckholtz, Joshua W, Meyer-Lindenberg, Andreas, Honea, Robyn A, Straub, Richard E, Pezawas, Lukas, Egan, Michael F, Vakkalanka, Radhakrishna, Kolachana, Bhaskar, Verchinski, Beth A, Sust, Steven, Mattay, Venkata S, Weinberger, Daniel R, Callicott, Joseph H

“…Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G alpha-GTP binding. Linkage, association,…”
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No Effect of a Common Allelic Variant in the Reelin Gene on Intermediate Phenotype Measures of Brain Structure, Brain Function, and Gene Expression by Tost, Heike, Lipska, Barbara K, Vakkalanka, Radhakrishna, Lemaitre, Herve, Callicott, Joseph H, Mattay, Venkata S, Kleinman, Joel E, Marenco, Stefano, Weinberger, Daniel R

“…Background A recent genome-wide association study linked a common variant in RELN (rs7 341475G ) with risk for schizophrenia in women. In the largest…”
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A 5′ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression by Nicodemus, K K, Law, A J, Luna, A, Vakkalanka, R, Straub, R E, Kleinman, J E, Weinberger, D R

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alpha 7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1 by Mathew, Shiny V, Law, Amanda J, Lipska, Barbara K, Davila-Garcia, Martha I, Zamora, Eduardo D, Mitkus, Shruti N, Vakkalanka, Radhakrishna, Straub, Richard E, Weinberger, Daniel R, Kleinman, Joel E, Hyde, Thomas M

“…Studies in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable schizophrenia susceptibility gene, regulates the expression of the alpha 7…”
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RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity by Lipska, Barbara K., Mitkus, Shruti, Caruso, Mark, Hyde, Thomas M., Chen, Jingshan, Vakkalanka, Radhakrishna, Straub, Richard E., Weinberger, Daniel R., Kleinman, Joel E.

“…Linkage, association and postmortem studies have implicated regulator of G-protein signaling 4 (RGS4), which negatively modulates signal transduction at…”
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Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110[delta] inhibition as a potential therapeutic strategy by Law, Amanda J, Wang, Yanhong, Sei, Yoshitatsu, O'Donnell, Patricio, Piantadosi, Patrick, Papaleo, Francesco, Straub, Richard E, Huang, Wenwei, Thomas, Craig J, Vakkalanka, Radhakrishna, Besterman, Aaron D, Lipska, Barbara K, Hyde, Thomas M, Harrison, Paul J, Kleinman, Joel E, Weinberger, Daniel R

“…Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a…”
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Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia by Shannon Weickert, C., Miranda-Angulo, A. L., Wong, J., Perlman, W. R., Ward, S. E., Radhakrishna, V., Straub, R. E., Weinberger, D. R., Kleinman, J. E.

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