Search Results - "VAKA, Dedeepya"

The role of exome sequencing in newborn screening for inborn errors of metabolism by Adhikari, Aashish N., Gallagher, Renata C., Wang, Yaqiong, Currier, Robert J., Amatuni, George, Bassaganyas, Laia, Chen, Flavia, Kundu, Kunal, Kvale, Mark, Mooney, Sean D., Nussbaum, Robert L., Randi, Savanna S., Sanford, Jeremy, Shieh, Joseph T., Srinivasan, Rajgopal, Sunderam, Uma, Tang, Hao, Vaka, Dedeepya, Zou, Yangyun, Koenig, Barbara A., Kwok, Pui-Yan, Risch, Neil, Puck, Jennifer M., Brenner, Steven E.

“…Public health newborn screening (NBS) programs provide population-scale ascertainment of rare, treatable conditions that require urgent intervention. Tandem…”
Get full text

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors by Jahchan, Nadine S, Dudley, Joel T, Mazur, Pawel K, Flores, Natasha, Yang, Dian, Palmerton, Alec, Zmoos, Anne-Flore, Vaka, Dedeepya, Tran, Kim Q T, Zhou, Margaret, Krasinska, Karolina, Riess, Jonathan W, Neal, Joel W, Khatri, Purvesh, Park, Kwon S, Butte, Atul J, Sage, Julien

“…Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with high mortality. We used a systematic drug repositioning…”
Get more information

Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis by Kareta, Michael S., Gorges, Laura L., Hafeez, Sana, Benayoun, Bérénice A., Marro, Samuele, Zmoos, Anne-Flore, Cecchini, Matthew J., Spacek, Damek, Batista, Luis F.Z., O’Brien, Megan, Ng, Yi-Han, Ang, Cheen Euong, Vaka, Dedeepya, Artandi, Steven E., Dick, Frederick A., Brunet, Anne, Sage, Julien, Wernig, Marius

“…Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of…”
Get full text

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo by VICENT, Silvestre, SAYLES, Leanne C, SHRAGER, Joseph, HOANG, Chuong D, PLEVRITIS, Sylvia, BUTTE, Atul J, ALEJANDRO SWEET-CORDERO, E, VAKA, Dedeepya, KHATRI, Purvesh, GEVAERT, Olivier, CHEN, Ron, ZHENG, Yanyan, GILLESPIE, Anna K, CLARKE, Nicole, YUE XU

“…Cancer-associated fibroblasts (CAF) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of…”
Get full text

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer by Jahchan, Nadine S., Lim, Jing Shan, Bola, Becky, Morris, Karen, Seitz, Garrett, Tran, Kim Q., Xu, Lei, Trapani, Francesca, Morrow, Christopher J., Cristea, Sandra, Coles, Garry L., Yang, Dian, Vaka, Dedeepya, Kareta, Michael S., George, Julie, Mazur, Pawel K., Nguyen, Thuyen, Anderson, Wade C., Dylla, Scott J., Blackhall, Fiona, Peifer, Martin, Dive, Caroline, Sage, Julien

“…Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We…”
Get full text

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer by Chiou, Shin-Heng, Risca, Viviana I, Wang, Gordon X, Yang, Dian, Grüner, Barbara M, Kathiria, Arwa S, Ma, Rosanna K, Vaka, Dedeepya, Chu, Pauline, Kozak, Margaret, Castellini, Laura, Graves, Edward E, Kim, Grace E, Mourrain, Philippe, Koong, Albert C, Giaccia, Amato J, Winslow, Monte M

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite the clinical significance of metastatic spread, our…”
Get more information

Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia by Dong, Weilai, Wong, Karen H.Y., Liu, Youbin, Levy-Sakin, Michal, Hung, Wei-Chien, Li, Mo, Li, Boyang, Jin, Sheng Chih, Choi, Jungmin, Lopez-Giraldez, Francesc, Vaka, Dedeepya, Poon, Annie, Chu, Catherine, Lao, Richard, Balamir, Melek, Movsesyan, Irina, Malloy, Mary J., Zhao, Hongyu, Kwok, Pui-Yan, Kane, John P., Lifton, Richard P., Pullinger, Clive R.

“…Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of…”
Get full text

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress by Oh, Sekyung, Flynn, Ryan A, Floor, Stephen N, Purzner, James, Martin, Lance, Do, Brian T, Schubert, Simone, Vaka, Dedeepya, Morrissy, Sorana, Li, Yisu, Kool, Marcel, Hovestadt, Volker, Jones, David T W, Northcott, Paul A, Risch, Thomas, Warnatz, Hans-Jörg, Yaspo, Marie-Laure, Adams, Christopher M, Leib, Ryan D, Breese, Marcus, Marra, Marco A, Malkin, David, Lichter, Peter, Doudna, Jennifer A, Pfister, Stefan M, Taylor, Michael D, Chang, Howard Y, Cho, Yoon-Jae

“…DDX3X encodes a DEAD-box family RNA helicase (DDX3) commonly mutated in medulloblastoma, a highly aggressive cerebellar tumor affecting both children and…”
Get full text

Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo by Ehmer, Ursula, Zmoos, Anne-Flore, Auerbach, Raymond K., Vaka, Dedeepya, Butte, Atul J., Kay, Mark A., Sage, Julien

“…In mammals, a cell’s decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of…”
Get full text

Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis by Wong, Karen H.Y., Levy‐Sakin, Michal, Ma, Walfred, Gonzaludo, Nina, Mak, Angel C.Y., Vaka, Dedeepya, Poon, Annie, Chu, Catherine, Lao, Richard, Balamir, Melek, Grenville, Zoe, Wong, Nicolas, Kane, John P., Kwok, Pui‐Yan, Malloy, Mary J., Pullinger, Clive R.

“…Background Homozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low‐density lipoprotein…”
Get full text

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal by Zheng, Yanyan, de la Cruz, Cecile C., Sayles, Leanne C., Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D., Bigos, Marty, Xu, Yue, Hoang, Chuong D., Shrager, Joseph B., Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A.D., Barck, Kai H., Jackson, Erica L., Sweet-Cordero, E. Alejandro

“…Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer…”
Get full text

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury by Palikuqi, Brisa, Rispal, Jérémie, Reyes, Efren A., Vaka, Dedeepya, Boffelli, Dario, Klein, Ophir

“…The intestinal epithelium undergoes continuous renewal and has an exceptional capacity to regenerate after injury. Maintenance and proliferation of intestinal…”
Get full text

Tissue signals imprint ILC2 identity with anticipatory function by Ricardo-Gonzalez, Roberto R., Van Dyken, Steven J., Schneider, Christoph, Lee, Jinwoo, Nussbaum, Jesse C., Liang, Hong-Erh, Vaka, Dedeepya, Eckalbar, Walter L., Molofsky, Ari B., Erle, David J., Locksley, Richard M.

“…Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial…”
Get full text

Comprehensive genomic profiles of small cell lung cancer by George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S., Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N., Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O., Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A., Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P., Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M., Russell, Prudence A., Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A., la Torre, Annamaria, Field, John K., Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B., Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M., Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D., Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A., Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, Thomas, Roman K.

“…We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic…”
Get full text

A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma by RON CHEN, KHATRI, Purvesh, BUTTE, Atul J, SWEET-CORDERO, E. Alejandro, MAZUR, Pawel K, POLIN, Melanie, YANYAN ZHENG, VAKA, Dedeepya, HOANG, Chuong D, SHRAGER, Joseph, YUE XU, VICENT, Silvestre

“…Lung cancer remains the most common cause of cancer-related death worldwide and it continues to lack effective treatment. The increasingly large and diverse…”
Get full text

Patterning and folding of intestinal villi by active mesenchymal dewetting by Huycke, Tyler R, Häkkinen, Teemu J, Miyazaki, Hikaru, Srivastava, Vasudha, Barruet, Emilie, McGinnis, Christopher S, Kalantari, Ali, Cornwall-Scoones, Jake, Vaka, Dedeepya, Zhu, Qin, Jo, Hyunil, Oria, Roger, Weaver, Valerie M, DeGrado, William F, Thomson, Matt, Garikipati, Krishna, Boffelli, Dario, Klein, Ophir D, Gartner, Zev J

“…Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to…”
Get more information

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains by Zwick, Rachel K., Kasparek, Petr, Palikuqi, Brisa, Viragova, Sara, Weichselbaum, Laura, McGinnis, Christopher S., McKinley, Kara L., Rathnayake, Asoka, Vaka, Dedeepya, Nguyen, Vinh, Trentesaux, Coralie, Reyes, Efren, Gupta, Alexander R., Gartner, Zev J., Locksley, Richard M., Gardner, James M., Itzkovitz, Shalev, Boffelli, Dario, Klein, Ophir D.

“…A key aspect of nutrient absorption is the exquisite division of labour across the length of the small intestine, with individual nutrients taken up at…”
Get full text

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis by Marques Howarth, Michelle, Simpson, David, Ngok, Siu P, Nieves, Bethsaida, Chen, Ron, Siprashvili, Zurab, Vaka, Dedeepya, Breese, Marcus R, Crompton, Brian D, Alexe, Gabriela, Hawkins, Doug S, Jacobson, Damon, Brunner, Alayne L, West, Robert, Mora, Jaume, Stegmaier, Kimberly, Khavari, Paul, Sweet-Cordero, E Alejandro

“…Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for…”
Get full text

Whole exome and whole genome sequencing with dried blood spot DNA without whole genome amplification by Bassaganyas, Laia, Freedman, George, Vaka, Dedeepya, Wan, Eunice, Lao, Richard, Chen, Flavia, Kvale, Mark, Currier, Robert J., Puck, Jennifer M., Kwok, Pui‐Yan

“…Newborn screening (NBS) for rare conditions is performed in all 50 states in the USA. We have partnered with the California Department of Public Health Genetic…”
Get full text

A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal by Zheng, Yanyan, de la Cruz, Cecile C, Sayles, Leanne C, Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D, Bigos, Marty, Xu, Yue, Hoang, Chuong D, Shrager, Joseph B, Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A D, Barck, Kai H, Jackson, Erica L, Sweet-Cordero, E Alejandro

“…Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer…”
Get full text