Search Results - "VAINIO, Paula"

FZD4 as a Mediator of ERG Oncogene―Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells by GUPTA, Santosh, ILJIN, Kristiina, SARA, Henri, MPINDI, John Patrick, MIRTTI, Tuomas, VAINIO, Paula, RANTALA, Juha, ALANEN, Kalle, NEES, Matthias, KALLIONIEMI, Olli

“…TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has…”
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Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells by Ketola, Kirsi, Vainio, Paula, Fey, Vidal, Kallioniemi, Olli, Iljin, Kristiina

“…Current treatment options for advanced and hormone refractory prostate cancer are limited and responses to commonly used androgen pathway inhibitors are often…”
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High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth by IIJIN, Kristiina, KETOLA, Kirsi, VAINIO, Paula, HALONEN, Pasi, KOHONEN, Pekka, FEY, Vidal, GRAFSTRÖM, Roland C, PERÄLÄ, Merja, KALLIONIEMI, Olli

“…Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most…”
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Tumor‐to‐tumor metastasis to Warthin tumor presenting as an initial sign of breast carcinoma: A case report by Mansikka, Iisa, Kinnunen, Ilpo, Hirvonen, Jussi, Vainio, Paula, Velhonoja, Jarno

“…Metastases of distant primary tumors on the parotid gland are very rare. Tumor‐to‐tumor metastasis to salivary gland tumors is extremely rare. A case of a…”
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Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues by Kilpinen, Sami, Autio, Reija, Ojala, Kalle, Iljin, Kristiina, Bucher, Elmar, Sara, Henri, Pisto, Tommi, Saarela, Matti, Skotheim, Rolf I, Björkman, Mari, Mpindi, John-Patrick, Haapa-Paananen, Saija, Vainio, Paula, Edgren, Henrik, Wolf, Maija, Astola, Jaakko, Nees, Matthias, Hautaniemi, Sampsa, Kallioniemi, Olli

“…Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the…”
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Arachidonic Acid Pathway Members PLA2G7 , HPGD , EPHX2 , and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer by Vainio, Paula, Gupta, Santosh, Ketola, Kirsi, Mirtti, Tuomas, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Perälä, Merja, Smit, Frank, Verhaegh, Gerald, Schalken, Jack, Alanen, Kalle A, Kallioniemi, Olli, Iljin, Kristiina

“…The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key…”
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A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma by Mattila, Kalle E., Laajala, Teemu D., Tornberg, Sara V., Kilpeläinen, Tuomas P., Vainio, Paula, Ettala, Otto, Boström, Peter J., Nisen, Harry, Elo, Laura L., Jaakkola, Panu M.

“…After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic…”
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High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer by Vainio, Paula, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Mirtti, Tuomas, Alanen, Kalle A, Perälä, Merja, Kallioniemi, Olli, Iljin, Kristiina

“…Prostate cancer is a heterogeneous group of diseases and there is a need for more efficient and targeted methods of treatment. In this study, the potential of…”
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Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma by Luomala, Lassi, Mattila, Kalle, Vainio, Paula, Nisén, Harry, Pellinen, Teijo, Lohi, Jouni, Laajala, Teemu D., Järvinen, Petrus, Koskenniemi, Anna‐Riina, Jaakkola, Panu, Mirtti, Tuomas

“…Background Hypoxia inducible factors, HIF‐1α and HIF‐2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to…”
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External validation of a deep learning-based algorithm for detection of tall cells in papillary thyroid carcinoma: A multicenter study by Stenman, Sebastian, Bétrisey, Sylvain, Vainio, Paula, Huvila, Jutta, Lundin, Mikael, Linder, Nina, Schmitt, Anja, Perren, Aurel, Dettmer, Matthias S., Haglund, Caj, Arola, Johanna, Lundin, Johan

“…The tall cell subtype (TC-PTC) is an aggressive subtype of papillary thyroid carcinoma (PTC). The TC-PTC is defined as a PTC comprising at least 30% epithelial…”
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GTI: a novel algorithm for identifying outlier gene expression profiles from integrated microarray datasets by Mpindi, John Patrick, Sara, Henri, Haapa-Paananen, Saija, Kilpinen, Sami, Pisto, Tommi, Bucher, Elmar, Ojala, Kalle, Iljin, Kristiina, Vainio, Paula, Björkman, Mari, Gupta, Santosh, Kohonen, Pekka, Nees, Matthias, Kallioniemi, Olli

“…Meta-analysis of gene expression microarray datasets presents significant challenges for statistical analysis. We developed and validated a new bioinformatic…”
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Integrative genomic, transcriptomic, and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer by Vainio, Paula, Wolf, Maija, Edgren, Henrik, He, Tao, Kohonen, Pekka, Mpindi, John-Patrick, Smit, Frank, Verhaegh, Gerald, Schalken, Jack, Perälä, Merja, Iljin, Kristiina, Kallioniemi, Olli

“…BACKGROUND Castration‐resistant prostate cancer (CRPC) represents a therapeutic challenge for current medications. METHODS In order to explore the molecular…”
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Correction: GTI: A Novel Algorithm for Identifying Outlier Gene Expression Profiles from Integrated Microarray Datasets by Mpindi, John Patrick, Sara, Henri, Haapa-Paananen, Saija, Kilpinen, Sami, Pisto, Tommi, Bucher, Elmar, Ojala, Kalle, Iljin, Kristiina, Vainio, Paula, Björkman, Mari, Gupta, Santosh, Kohonen, Pekka, Nees, Matthias, Kallioniemi, Olli

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Molecular subtype diagnosis of endometrial carcinoma: comparison of the next-generation sequencing panel and Proactive Molecular Risk Classifier for Endometrial Cancer classifier by Huvila, Jutta, Orte, Katri, Vainio, Paula, Mettälä, Tuukka, Joutsiniemi, Titta, Hietanen, Sakari

“…The Cancer Genome Atlas–based molecular classification of endometrial carcinoma (EC) has the potential to better identify those patients whose disease is…”
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Somatostatin Receptor Expression Is Associated With Metastasis and Patient Outcome in Pulmonary Carcinoid Tumors by Vesterinen, Tiina, Leijon, Helena, Mustonen, Harri, Remes, Satu, Knuuttila, Aija, Salmenkivi, Kaisa, Vainio, Paula, Arola, Johanna, Haglund, Caj

“…Abstract Context Pulmonary carcinoids (PCs) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTRs). This overexpression provides…”
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Prognostic Factors for Localized Clear Cell Renal Cell Carcinoma and Their Application in Adjuvant Therapy by Mattila, Kalle E, Vainio, Paula, Jaakkola, Panu M

“…Approximately 20% of patients with renal cell carcinoma (RCC) present with primarily metastatic disease and over 30% of patients with localized RCC will…”
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Novel COL1A1 Mutation c.3290G>T Associated With Severe Form of Osteogenesis Imperfecta in a Fetus by Tanner, Laura, Vainio, Paula, Sandell, Minna, Laine, Jukka

“…Osteogenesis imperfecta is a genetically and clinically heterogenous group of skeletal dysplasias characterized by bone fragility. Its severity ranges from…”
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Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth by Olotu, Opeyemi, Koskenniemi, Anna-Riina, Ma, Lin, Paramonov, Valeriy, Laasanen, Sini, Louramo, Elina, Bourgery, Matthieu, Lehtiniemi, Tiina, Laasanen, Samuli, Rivero-Müller, Adolfo, Löyttyniemi, Eliisa, Sahlgren, Cecilia, Westermarck, Jukka, Ventelä, Sami, Visakorpi, Tapio, Poutanen, Matti, Vainio, Paula, Mäkelä, Juho-Antti, Kotaja, Noora

“…Cancer cells undergo major epigenetic alterations and transcriptomic changes, including ectopic expression of tissue- and cell-type-specific genes. Here, we…”
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IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole‐mount prostatectomy sections and implications for focal therapy by Merisaari, Harri, Jambor, Ivan, Ettala, Otto, Boström, Peter J., Montoya Perez, Ileana, Verho, Janne, Kiviniemi, Aida, Syvänen, Kari, Kähkönen, Esa, Eklund, Lauri, Pahikkala, Tapio, Vainio, Paula, Saunavaara, Jani, Aronen, Hannu J., Taimen, Pekka

“…Background Prostate MRI is increasingly being used in men with a clinical suspicion of prostate cancer (PCa). However, development and validation of methods…”
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Abstract 5490: Spatial profiling of inflamed tumor microenvironment of clear cell renal cell carcinoma by Pellinen, Teijo, Luomala, Lassi, Mattila, Kalle, Säilä, Jenni, Hemmes, Annabrita, Valimaki, Katja, Bruck, Oscar, Paavolainen, Lassi, Nisen, Harry, Järvinen, Petrus, Kallioniemi, Olli, Vainio, Paula, Jaakkola, Panu, Mirtti, Tuomas

“…Abstract Clear cell renal cell carcinoma (ccRCC) presents a distinctive tumor microenvironment (TME) characterized by extensive vascularization and immune…”
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