Search Results - "VAILLANCOURT, Cathy"
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Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells
Published in PloS one (10-01-2019)“…Melatonin has protective roles in normal cells and cytotoxic actions in cancer cells, with effects involving autophagy and nuclear factor (erythroid-derived…”
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Effects of prenatal maternal stress on serotonin and fetal development
Published in Placenta (Eastbourne) (01-12-2016)“…Abstract Fetuses are exposed to many environmental perturbations that can influence their development. These factors can be easily identifiable such as drugs,…”
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The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice
Published in International journal of molecular sciences (30-05-2023)“…Bile acids (BAs) are natural ligands for several receptors modulating cell activities. BAs are synthesized via the classic (neutral) and alternative (acidic)…”
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Serotonin-estrogen interactions: What can we learn from pregnancy?
Published in Biochimie (01-06-2019)“…We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked…”
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Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation
Published in Journal of pineal research (01-11-2018)“…Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such as autophagy, inflammation, and apoptosis…”
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Human placental trophoblasts synthesize melatonin and express its receptors
Published in Journal of pineal research (01-08-2008)“…: Although the role of melatonin on fetal development has been the subject of a number of studies, little is known about the function of melatonin in the…”
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A simple method to assess group difference in RT-qPCR reference gene selection using GeNorm: The case of the placental sex
Published in Scientific reports (05-12-2017)“…Normalization with proper reference genes is a crucial step in obtaining accurate mRNA expression levels in RT-qPCR experiments. GeNorm and NormFinder are two…”
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Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction
Published in The Journal of immunology (1950) (01-01-2017)“…Excessive placental inflammation is associated with several pathological conditions, including stillbirth and fetal growth restriction. Although infection is a…”
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Directed biomechanical compressive forces enhance fusion efficiency in model placental trophoblast cultures
Published in Scientific reports (17-05-2024)“…The syncytiotrophoblast is a multinucleated structure that arises from fusion of mononucleated cytotrophoblasts, to sheath the placental villi and regulate…”
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Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy
Published in Scientific reports (30-12-2022)“…Selective serotonin reuptake inhibitors (SSRIs) for treatment of prenatal maternal depression have been associated with neonatal neurobehavioral disturbances,…”
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Melatonin in Pregnancy: Effects on Brain Development and CNS Programming Disorders
Published in Current pharmaceutical design (01-03-2016)“…Melatonin is an important neuroprotective factor and its receptors are expressed in the fetal brain. During normal pregnancy, maternal melatonin level…”
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In utero exposure to venlafaxine, a serotonin-norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat
Published in Birth defects research. A Clinical and molecular teratology (01-12-2016)“…Background Human studies are inconsistent with respect to an association between treatment with selective serotonin and serotonin–norepinephrine reuptake…”
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Breastfeeding and the gut-brain axis: is there a role for melatonin?
Published in Biomolecular concepts (26-09-2017)“…The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a…”
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Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin
Published in Cell reports (Cambridge) (19-03-2019)“…Tryptophan as the precursor of several active compounds, including kynurenine and serotonin, is critical for numerous important metabolic functions. Enhanced…”
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Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF
Published in Cells (Basel, Switzerland) (01-01-2024)“…Interleukin-6 (IL-6) superfamily cytokines play critical roles during human pregnancy by promoting trophoblast differentiation, invasion, and endocrine…”
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Isolation and culture of term human cytotrophoblast cells and in vitro methods for studying human cytotrophoblast cells' calcium uptake
Published in Methods in molecular biology (Clifton, N.J.) (2009)“…Human primary cytotrophoblast cell culture is a very useful model to study the endocrine and immunological functions of syncytiotrophoblasts, as well as the…”
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Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus
Published in Biochimica et biophysica acta. Molecular basis of disease (01-02-2020)“…Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis…”
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Addressing the Environmental, Community, and Health Impacts of Resource Development: Challenges across Scales, Sectors, and Sites
Published in Challenges (Basel) (20-03-2019)“…Work that addresses the cumulative impacts of resource extraction on environment, community, and health is necessarily large in scope. This paper presents…”
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RETRACTED: Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus
Published in Biochimica et biophysica acta. Molecular basis of disease (01-02-2020)“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal)…”
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Engineering placental trophoblast fusion: A potential role for biomechanics in syncytialization
Published in Placenta (Eastbourne) (01-11-2024)“…The process by which placental trophoblasts fuse to form the syncytiotrophoblast around the chorionic villi is not fully understood. Mechanical features of the…”
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