Search Results - "VADALA, Gianluca"

Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do by Vadalà, Gianluca, Ambrosio, Luca, Russo, Fabrizio, Papalia, Rocco, Denaro, Vincenzo

“…BACKGROUNDLow back pain (LPB) is the main cause of disability worldwide with enormous socioeconomic burdens. A major cause of LBP is intervertebral disc…”
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Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells? by Loibl, Markus, Wuertz‐Kozak, Karin, Vadala, Gianluca, Lang, Siegmund, Fairbank, Jeremy, Urban, Jill P.

“…Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly…”
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Coculture of Bone Marrow Mesenchymal Stem Cells and Nucleus Pulposus Cells Modulate Gene Expression Profile Without Cell Fusion by VADALA, Gianluca, STUDER, Rebecca K, SOWA, Gwendolyn, SPIEZIA, Filippo, IUCU, Cristina, DENARO, Vincenzo, GILBERTSON, Lars G, KANG, James D

“…Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. To…”
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Feasibility of a stem cell therapy for intervertebral disc degeneration by Sobajima, Satoshi, MD, Vadala, Gianluca, MD, Shimer, Adam, MD, Kim, Joseph S., MD, Gilbertson, Lars G., PhD, Kang, James D., MD

“…Editor's preface Background context Different strategies to supplement/replenish the disc cell population have been proposed. Recently, adult stem cells have…”
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Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative by Le Maitre, Christine L., Dahia, Chitra L., Giers, Morgan, Illien‐Junger, Svenja, Cicione, Claudia, Samartzis, Dino, Vadala, Gianluca, Fields, Aaron, Lotz, Jeffrey

“…Background Histopathological analysis of intervertebral disc (IVD) tissues is a critical domain of back pain research. Identification, description, and…”
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Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas by Musumeci, Maria, Vadalà, Gianluca, Tringali, Giovanni, Insirello, Elio, Roccazzello, Anna Maria, Simpore, Jacques, Musumeci, Salvatore

“…The aim of this study was to determine the prevalence of known gene polymorphisms associated with osteoporosis in postmenopausal normal women from Burkina Faso…”
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Intervertebral disc degeneration: A focus on obesity and type 2 diabetes by Cannata, Francesca, Vadalà, Gianluca, Ambrosio, Luca, Fallucca, Sara, Napoli, Nicola, Papalia, Rocco, Pozzilli, Paolo, Denaro, Vincenzo

“…Summary Obesity (OB) and type 2 diabetes (T2D) are among the most prevalent metabolic diseases. They currently affect a substantial part of the world…”
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Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering by Papalia, Rocco, Russo, Fabrizio, Ambrosio, Luca, Vadalà, Gianluca, Denaro, Vincenzo

“…Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the population worldwide. Its primary cause seems to be intervertebral disc…”
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Effect of bupivacaine on intervertebral disc cell viability by Lee, Ho, MD, PhD, Sowa, Gwendolyn, MD, PhD, Vo, Nam, PhD, Vadala, Gianluca, MD, O'Connell, Stephen, DO, Studer, Rebecca, PhD, Kang, James, MD

“…Abstract Background context Bupivacaine is a local anesthetic commonly used to relieve or control pain in interventional spine procedures. Bupivacaine has been…”
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Anterior Cruciate Ligament Repair Augmented With Dynamic Intraligamentary Stabilization Is Equivalent to Hamstring Autograft Reconstruction at Short- and Mid-Term Follow-Up: A Systematic Review by Ambrosio, Luca, Franco, Domenico, Vadalà, Gianluca, Russo, Fabrizio, Papalia, Rocco

“…To compare clinical outcomes, knee stability and complications, failure, and revision rates after anterior cruciate ligament repair (ACLr) with dynamic…”
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Invasive Intraneural Interfaces: Foreign Body Reaction Issues by Lotti, Fiorenza, Ranieri, Federico, Vadalà, Gianluca, Zollo, Loredana, Di Pino, Giovanni

“…Intraneural interfaces are stimulation/registration devices designed to couple the peripheral nervous system (PNS) with the environment. Over the last years,…”
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Innovative Biomaterials for the Treatment of Bone Cancer by Ambrosio, Luca, Raucci, Maria Grazia, Vadalà, Gianluca, Ambrosio, Luigi, Papalia, Rocco, Denaro, Vincenzo

“…Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions…”
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Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention by Cannata, Francesca, Vadalà, Gianluca, Ambrosio, Luca, Napoli, Nicola, Papalia, Rocco, Denaro, Vincenzo, Pozzilli, Paolo

“…Summary Over the last decades, osteoarthritis (OA) and type 2 diabetes (T2D) prevalence increased due to the global ageing population and the pandemic obesity…”
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Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation by Russo, Fabrizio, D'Este, Matteo, Vadalà, Gianluca, Cattani, Caterina, Papalia, Rocco, Alini, Mauro, Denaro, Vincenzo

“…Osteoarthritis (OA) is the most common musculoskeletal disease. Current treatments for OA are mainly symptomatic and inadequate since none results in…”
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COVID-19 Pandemic Increases the Impact of Low Back Pain: A Systematic Review and Metanalysis by Papalia, Giuseppe Francesco, Petrucci, Giorgia, Russo, Fabrizio, Ambrosio, Luca, Vadalà, Gianluca, Iavicoli, Sergio, Papalia, Rocco, Denaro, Vincenzo

“…In March 2019, the World Health Organization (WHO) recognized the COVID-19 pandemic as a global issue. To reduce the spread of this disease, health safety…”
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Effect of Irisin on Human Nucleus Pulposus Cells: New Insights into the Biological Cross-talk Between Muscle and Intervertebral Disk by Vadalà, Gianluca, Di Giacomo, Giuseppina, Ambrosio, Luca, Cicione, Claudia, Tilotta, Veronica, Russo, Fabrizio, Papalia, Rocco, Denaro, Vincenzo

“…In vitro study. To investigate the effect of irisin on human nucleus pulposus cells (hNPCs) in vitro. Physical exercise (PE) favours weight loss and…”
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Sclerostin Regulation, Microarchitecture, and Advanced Glycation End‐Products in the Bone of Elderly Women With Type 2 Diabetes by Piccoli, Alessandra, Cannata, Francesca, Strollo, Rocky, Pedone, Claudio, Leanza, Giulia, Russo, Fabrizio, Greto, Valentina, Isgrò, Camilla, Quattrocchi, Carlo Cosimo, Massaroni, Carlo, Silvestri, Sergio, Vadalà, Gianluca, Bisogno, Tiziana, Denaro, Vincenzo, Pozzilli, Paolo, Tang, Simon Y, Silva, Matt J, Conte, Caterina, Papalia, Rocco, Maccarrone, Mauro, Napoli, Nicola

“…ABSTRACT Increased circulating sclerostin and accumulation of advanced glycation end‐products (AGEs) are two potential mechanisms underlying low bone turnover…”
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The Effects of Workplace Interventions on Low Back Pain in Workers: A Systematic Review and Meta-Analysis by Russo, Fabrizio, Papalia, Giuseppe Francesco, Vadalà, Gianluca, Fontana, Luca, Iavicoli, Sergio, Papalia, Rocco, Denaro, Vincenzo

“…This systematic review and meta-analysis aimed to analyze the effects of workplace interventions (WI) on clinical outcomes related to low back pain (LBP) in a…”
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Does Workers’ Compensation Status Affect Outcomes after Lumbar Spine Surgery? A Systematic Review and Meta-Analysis by Russo, Fabrizio, De Salvatore, Sergio, Ambrosio, Luca, Vadalà, Gianluca, Fontana, Luca, Papalia, Rocco, Rantanen, Jorma, Iavicoli, Sergio, Denaro, Vincenzo

“…Low back pain (LBP) is currently the leading cause of disability worldwide and the most common reason for workers’ compensation (WC) claims. Studies have…”
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Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength by Leanza, Giulia, Cannata, Francesca, Faraj, Malak, Pedone, Claudio, Viola, Viola, Tramontana, Flavia, Pellegrini, Niccolò, Vadalà, Gianluca, Piccoli, Alessandra, Strollo, Rocky, Zalfa, Francesca, Beeve, Alec T, Scheller, Erica L, Tang, Simon Y, Civitelli, Roberto, Maccarrone, Mauro, Papalia, Rocco, Napoli, Nicola

“…Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that bone formation genes ( and ) and…”
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