Search Results - "VACHER, S"

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer by Lodillinsky, C, Infante, E, Guichard, A, Chaligné, R, Fuhrmann, L, Cyrta, J, Irondelle, M, Lagoutte, E, Vacher, S, Bonsang-Kitzis, H, Glukhova, M, Reyal, F, Bièche, I, Vincent-Salomon, A, Chavrier, P

“…The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement membrane (BM). However, mechanisms…”
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Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers by Coussy, F, El Botty, R, Lavigne, M, Gu, C, Fuhrmann, L, Briaux, A, de Koning, L, Dahmani, A, Montaudon, E, Morisset, L, Huguet, L, Sourd, L, Painsec, P, Chateau-Joubert, S, Larcher, T, Vacher, S, Melaabi, S, Salomon, A Vincent, Marangoni, E, Bieche, I

“…Metaplastic breast cancer (MBC) is a rare form of breast cancer characterized by an aggressive clinical presentation, with a poor response to standard…”
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Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival by Dubot, C., Bernard, V., Sablin, M.P., Vacher, S., Chemlali, W., Schnitzler, A., Pierron, G., Ait Rais, K., Bessoltane, N., Jeannot, E., Klijanienko, J., Mariani, O., Jouffroy, T., Calugaru, V., Hoffmann, C., Lesnik, M., Badois, N., Berger, F., Le Tourneau, C., Kamal, M., Bieche, I.

“…We aimed at identifying deleterious genomic alterations from untreated head and neck squamous cell carcinoma (HNSCC) patients, and assessing their prognostic…”
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Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach by Tozlu, S, Girault, I, Vacher, S, Vendrell, J, Andrieu, C, Spyratos, F, Cohen, P, Lidereau, R, Bieche, I

“…The estrogen receptor alpha (ERα) plays a critical role in the pathogenesis and clinical behavior of breast cancer. To obtain further insights into the…”
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ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors by Vargas, G., Bouchet, M., Bouazza, L., Reboul, P., Boyault, C., Gervais, M., Kan, C., Benetollo, C., Brevet, M., Croset, M., Mazel, M., Cayrefourcq, L., Geraci, S., Vacher, S., Pantano, F., Filipits, M., Driouch, K., Bieche, I., Gnant, M., Jacot, W., Aubin, J. E., Duterque-Coquillaud, M., Alix-Panabières, C., Clézardin, P., Bonnelye, E.

“…Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we…”
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Clinical value of R-spondins in triple-negative and metaplastic breast cancers by Coussy, F, Lallemand, F, Vacher, S, Schnitzler, A, Chemlali, W, Caly, M, Nicolas, A, Richon, S, Meseure, D, El Botty, R, De-Plater, L, Fuhrmann, L, Dubois, T, Roman-Roman, S, Dangles-Marie, V, Marangoni, E, Bièche, I

“…Background: RSPO ligands, activators of the Wnt/ β -catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the…”
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ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels by Rondeau, S, Vacher, S, De Koning, L, Briaux, A, Schnitzler, A, Chemlali, W, Callens, C, Lidereau, R, Bièche, I

“…Background: Ataxia telangiectasia mutated (ATM) is a kinase that has a central role in the maintenance of genomic integrity by activating cell cycle…”
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A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation by Weiswald, L-B, Richon, S, Massonnet, G, Guinebretière, J-M, Vacher, S, Laurendeau, I, Cottu, P, Marangoni, E, Nemati, F, Validire, P, Bellet, D, Bièche, I, Dangles-Marie, V

“…Background: Ex vivo colospheres have been previously characterised as a colorectal cancer (CRC) well-rounded multicellular model, exclusively formed by…”
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Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets by Moreira, A., Masliah-Planchon, J., Callens, C., Vacher, S., Lecerf, C., Frelaut, M., Borcoman, E., Torossian, N., Ricci, F., Hescot, S., Sablin, M.P., Tresca, P., Loirat, D., Melaabi, S., Trabelsi-Grati, O., Pierron, G., Gentien, D., Bernard, V., Vincent Salomon, A., Servant, N., Bieche, I., Le Tourneau, C., Kamal, M.

“…A randomised trial SHIVA01 compared the efficacy of matched molecularly targeted therapy outside their indications based on a prespecified treatment algorithm…”
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Hedgehog pathway activation in human transitional cell carcinoma of the bladder by Pignot, G, Vieillefond, A, Vacher, S, Zerbib, M, Debre, B, Lidereau, R, Amsellem-Ouazana, D, Bieche, I

“…Background: The Hedgehog (Hh) signalling pathway functions as an organiser in embryonic development. Recent studies have shown constitutive activation of this…”
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Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer? by Lerebours, F., Vacher, S., Guinebretiere, J.M., Rondeau, S., Caly, M., Gentien, D., Van Laere, S., Bertucci, F., de la Grange, P., Bièche, l., Liang, X., Callens, C.

“…[Display omitted] Inflammatory Breast Cancer (IBC) is the most aggressive form of breast carcinoma characterized by rapid onset of inflammatory signs and its…”
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Guidelines of the French Society of Otorhinolaryngology (SFORL) for teleconsultation in patients with vertigo during the COVID-19 pandemic by Bertholon, P., Thai-Van, H., Bouccara, D., Esteve-Fraysse, M.-J., Wiener-Vacher, S.R., Ionescu, E.

“…In the context of the SARS-CoV-2 pandemic, patients may have been dissuaded from seeking consultation, thus exposing themselves to a risk of loss of chance…”
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Prognostic value of immune gene’s expression in head and neck squamous cell carcinoma patients by Lecerf, C., Kamal, M., Vacher, S., Chemlali, W., Dubot, C., Jeannot, E., Klijanienko, J., Hoffmann, C., Bieche, I., Le Tourneau, C.

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Inactivation of Aspergillus niger spores from indoor air by photocatalytic filters by Pigeot-Remy, S., Real, P., Simonet, F., Hernandez, C., Vallet, C., Lazzaroni, J.C., Vacher, S., Guillard, C.

“…Optical microscopy of the inside of a photocatalytic AC filter after the coating of fungal spores and 8 days of incubation in the dark at 25°C and 98% RH…”
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CXC chemokines located in the 4q21 region are up-regulated in breast cancer by Bièche, Ivan, Chavey, Carine, Andrieu, Catherine, Busson, Muriel, Vacher, Sophie, Le Corre, Ludovic, Guinebretière, Jean-Marc, Burlinchon, Sandrine, Lidereau, Rosette, Lazennec, Gwendal

“…Recent data suggest that chemokines could be essential players in breast carcinogenesis. We previously showed that the CXC chemokine CXCL8 (interleukin-8) was…”
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Vestibular impact of Friedreich ataxia in early onset patients by Maudoux, A, Teissier, N, Francois, M, Van Den Abbeele, Th, Alberti, C, Husson, I, Wiener-Vacher, S R

“…Friedreich ataxia (FRDA) is the most frequent form of inherited ataxias. Vestibular and auditory assessments are not commonly part of the check up for these…”
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Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components by Rath, Emma M, Duff, Anthony P, Håkansson, Anders P, Vacher, Catherine S, Liu, Guo Jun, Knott, Robert B, Church, William Bret

“…The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class…”
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In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland by El Sheikh Saad, H, Toullec, A, Vacher, S, Pocard, M, Bieche, I, Perrot-Applanat, M

“…Exposure to low doses of environmental estrogens such as bisphenol A and genistein (G) alters mammary gland development. The effects of environmental…”
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Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery by Moreira, A., Poulet, A., Masliah-Planchon, J., Lecerf, C., Vacher, S., Larbi Chérif, L., Dupain, C., Marret, G., Girard, E., Syx, L., Hoffmann, C., Jeannot, E., Klijanienko, J., Guillou, I., Mariani, O., Dubray-Vautrin, A., Badois, N., Lesnik, M., Choussy, O., Calugaru, V., Borcoman, E., Baulande, S., Legoix, P., Albaud, B., Servant, N., Bieche, I., Le Tourneau, C., Kamal, M.

“…Oral cavity is the most prevalent site of head and neck squamous cell carcinomas (HNSCCs). Most often diagnosed at a locally advanced stage, treatment is…”
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Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin by Saad, H. El Sheikh, Meduri, G., Phrakonkham, P., Bergès, R., Vacher, S., Djallali, M., Auger, J., Canivenc-Lavier, M.C., Perrot-Applanat, M.

“…The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to…”
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