Search Results - "VAANANEN, H. K"

Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading by Imai, S, Heino, T.J, Hienola, A, Kurata, K, Büki, K, Matsusue, Y, Väänänen, H.K, Rauvala, H

“…Abstract HB-GAM (also known as pleiotrophin) is a cell matrix-associated protein that is highly expressed in bone. It affects osteoblast function, and might…”
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Strong Prediction of Fractures Among Older Adults by the Ratio of Carboxylated to Total Serum Osteocalcin by Luukinen, H., Käkönen, S.‐M., Pettersson, K., Koski, K., Laippala, P., Lövgren, T., Kivelä, S.‐L., Väänänen, H. K.

“…We examined serum total osteocalcin (TOC), carboxylated osteocalcin (COC), and their ratio (COC/TOC) by one‐step two‐site immunofluorescent assays in 87% (n =…”
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Tartrate‐Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption by Halleen, Jussi M., Alatalo, Sari L., Suominen, Harri, Cheng, Sulin, Janckila, Anthony J., Väänänen, H. Kalervo

“…Human serum contains two forms of tartrate‐resistant acid phosphatase (TRAP), 5a and 5b. Of these, 5a contains sialic acid and 5b does not. We show here that…”
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Characterization of circulating human osteoclast progenitors: development of in vitro resorption assay by Husheem, M, Nyman, J K E, Vääräniemi, J, Vaananen, H K, Hentunen, T A

“…Several cell surface markers were used to isolate monocytes as osteoclast progenitors with an immunomagnetic cell separation system. Use of this system with…”
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Removal of Osteoclast Bone Resorption Products by Transcytosis by Salo, Jari, Lehenkari, Petri, Mulari, Mika, Metsikkö, Kalervo, Väänänen, H. Kalervo

“…Osteoclasts are multinucleated cells responsible for bone resorption. During the resorption cycle, osteoclasts undergo dramatic changes in their polarity, and…”
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Serum TRACP 5b and ICTP as Markers of Bone Metastases in Breast Cancer by KORPELA, J, TIITINEN, S. L, HIEKKANEN, H, HALLEEN, J. M, SELANDER, K. S, VÄÄNÄNEN, H. K, SUOMINEN, P, HELENIUS, H, SALMINEN, E

“…Background: The purpose of this cross-sectional study was to evaluate the value of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal…”
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Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption by HALLEEN, Jussi M, ALATALO, Sari L, JANCKILA, Anthony J, WOITGE, Henning W, SEIBEL, Markus J, VÄÄNÄNEN, H. Kalervo

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Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of skeletal changes in prostate cancer by Salminen, Eeva, Ala-Houhala, M, Korpela, J, Varpula, M, Tiitinen, S L, Halleen, J M, Väänänen, H K

“…Skeletal metastases are a significant problem in prostate cancer (PC). The patients are also exposed to treatment-related skeletal changes. This…”
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Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes by Kähkönen, T.E., Ivaska, K.K., Jiang, M., Büki, K.G., Väänänen, H.K., Härkönen, P.L.

“…Fibroblast growth factors (FGF) and their receptors (FGFRs) regulate many developmental processes including differentiation of mesenchymal stromal cells (MSC)…”
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The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure by Väänänen, H K, Horton, M

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The Effect of Oral Glucose Tolerance Test on Serum Osteocalcin and Bone Turnover Markers in Young Adults by Paldánius, P. M., Ivaska, K. K., Hovi, P., Andersson, S., Väänänen, H. K., Kajantie, E., Mäkitie, O.

“…Osteocalcin (OC) is an osteoblast-derived protein implicated in the regulation of glucose tolerance and energy metabolism. This endocrine function has been…”
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Clinical Significance of Immunoassays for Type-5 Tartrate-resistant Acid Phosphatase by Nakasato, Yuri R, Janckila, Anthony J, Halleen, Jussi M, Vaananen, H. Kalervo, Walton, Stephanie P, Yam, Lung T

“…Tartrate-resistant acid phosphatase (TRAP; EC 3.1.3.2) is a product of osteoclasts and a biochemical marker of bone resorption rate. However, erythrocytes and…”
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Effect of impact exercise on bone metabolism by Vainionpää, A, Korpelainen, R, Väänänen, H. K, Haapalahti, J, Jämsä, T, Leppäluoto, J

“…Summary Regular impact exercise in premenopausal women caused positive osteogenic effects associated to low basal serum parathormone (PTH) but had no effects…”
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Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro by Michael, H, Härkönen, P L, Kangas, L, Väänänen, H K, Hentunen, T A

“…Background and purpose: Several selective oestrogen receptor modulators (SERMs) with oestrogen agonist effects in bone cells and without increased risk of…”
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The cell biology of osteoclast function by Väänänen, H K, Zhao, H, Mulari, M, Halleen, J M

“…Osteoclasts are multinucleated cells responsible for bone resorption. They have developed an efficient machinery for dissolving crystalline hydroxyapatite and…”
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Development and Evaluation of Three Immunofluorometric Assays That Measure Different Forms of Osteocalcin in Serum by Kakonen, Sanna-Maria, Hellman, Jukka, Karp, Matti, Laaksonen, Pirjo, Obrant, Karl J, Vaananen, H. Kalervo, Lovgren, Timo, Pettersson, Kim

“…Circulating human osteocalcin (hOC) has been used as a marker of bone formation. Our aim was to validate three immunofluorometric assays (IFMAs), measuring…”
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HRT and exercise: effects on bone density, muscle strength and lipid metabolism. A placebo controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women by Heikkinen, Jorma, Kyllönen, Eero, Kurttila-Matero, Eeva, Wilén-Rosenqvist, Gunilla, Lankinen, Kari S., Rita, Heli, Väänänen, H.Kalervo

“…Objectives: To evaluate the effect of 1- or 3-monthly sequential combinations of estradiol valerate (E 2V) and medroxyprogesterone acetate (MPA) on menopausal…”
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Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption by Michael, Husheem, Härkönen, Pirkko L, Väänänen, H Kalervo, Hentunen, Teuvo A

“…Using human peripheral blood CD14+ osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological…”
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Characterization of Serum Tartrate‐Resistant Acid Phosphatase and Development of a Direct Two‐Site Immunoassay by Halleen, Jussi M., Hentunen, Teuvo A., Karp, Matti, Käkönen, Sanna‐Maria, Pettersson, Kim, Väänänen, H. Kalervo

“…Osteoclasts secrete tartrate‐resistant acid phosphatase (TRAP) to the circulation, where the amount of TRAP is expected to correlate with the bone resorption…”
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Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture by Qu, Q., Perälä-Heape, M., Kapanen, A., Dahllund, J., Salo, J., Väänänen, H.K., Härkönen, P.

“…The effects of estrogen on bone are possibly mediated by several cell types. In the present study, the effect of 17β-estradiol (E 2) on osteoblast-like cells…”
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