Early-life inflammation with LPS delays fear extinction in adult rodents

Highlights • P14 LPS activates neurons in the central amygdala. • Early-life inflammation delays cued fear extinction in adult rats. • P14 LPS has no effect on contextual fear conditioning and extinction. • Anxiety-like phenotypes are increased only in adolescent females. • LPS on P14 does not affec...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 63; pp. 176 - 185
Main Authors:	V.M.Doenni, C.M.Song, Hill, M.N, Q.J.Pittman
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-07-2017
Subjects:	Adaptation, Psychological Allergy and Immunology Amygdala Amygdala - drug effects Animals Anxiety Anxiety - metabolism Anxiety Disorders Conditioning (Psychology) - physiology Conditioning, Classical - physiology Cues Cytokines Extinction Extinction, Psychological - drug effects Fear - physiology Female Inflammation Learning Lipopolysaccharides - pharmacology Male Mental Recall - physiology Pavlovian conditioning Psychiatry PTSD Rats Rats, Sprague-Dawley Rodentia Stress Stress, Psychological - immunology PTSD Pavlovian conditioning Amygdala Cytokines Extinction Anxiety Inflammation Stress
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Summary:	Highlights • P14 LPS activates neurons in the central amygdala. • Early-life inflammation delays cued fear extinction in adult rats. • P14 LPS has no effect on contextual fear conditioning and extinction. • Anxiety-like phenotypes are increased only in adolescent females. • LPS on P14 does not affect pain sensitivity or anxiety in adult rats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.11.022