Search Results - "V. Zavarzin, Igor"

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells by Scherbakov, Alexander M, Komkov, Alexander V, Komendantova, Anna S, Yastrebova, Margarita A, Andreeva, Olga E, Shirinian, Valerii Z, Hajra, Alakananda, Zavarzin, Igor V, Volkova, Yulia A

“…Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective…”
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Novel d-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells by Vorontsova, Svetlana K, Yadykov, Anton V, Scherbakov, Alexander M, Minyaev, Mikhail E, Zavarzin, Igor V, Mikhaevich, Ekaterina I, Volkova, Yulia A, Shirinian, Valerii Z

“…The acid-catalyzed cyclization of benzylidenes based on 16-dehydropregnenolone acetate (16-DPA) was studied. It was found that these compounds readily undergo…”
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Regio- and Chemoselective Bromination of 2,3-Diarylcyclopent-2-en-1-ones by Shirinian, Valerii Z, Lonshakov, Dmitry V, Kachala, Vadim V, Zavarzin, Igor V, Shimkin, Alexey A, Lvov, Andrew G, Krayushkin, Mikhail M

“…The bromination of 2,3-diarylcyclopent-2-en-1-ones under various conditions has been studied. It was found that depending on the brominating reagent and nature…”
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Design, synthesis and structure-activity studies of rhodanine derivatives as HIV-1 integrase inhibitors by Ramkumar, Kavya, Yarovenko, Vladimir N, Nikitina, Alexandra S, Zavarzin, Igor V, Krayushkin, Mikhail M, Kovalenko, Leonid V, Esqueda, Adrian, Odde, Srinivas, Neamati, Nouri

“…Raltegravir was the first HIV-1 integrase inhibitor that gained FDA approval for use in the treatment of HIV-1 infection. Because of the emergence of IN…”
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Difluoroboron complexes as versatile precursors for steroid modification. Lumiestrone-based steroid derivatives: synthesis and structural studies by Minyaev, Mikhail E, Sukhanova, Anna A, Prezent, Mikhail A, Zavarzin, Igor V

“…A preparation method for steroid-based difluoroboron complexes has been developed using lumiestrone as a steroid example. Previously inaccessible…”
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Synthesis of Dibenzo[d,f][1,3]Diazepines via Elemental Sulfur-Mediated Cyclocondensation of 2,2′-Biphenyldiamines with 2‑Chloroacetic Acid Derivatives by Tikhonova, Tatyana A, Lyssenko, Konstantin A, Zavarzin, Igor V, Volkova, Yulia A

“…The three-component reaction of 2,2′-biphenyldiamines with 2-chloroacetic acid derivatives and elemental sulfur was developed for the practical synthesis of…”
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Selective ligands of membrane progesterone receptors as a key to studying their biological functions in vitro and in vivo by Levina, Inna S., Kuznetsov, Yury V., Shchelkunova, Tatiana A., Zavarzin, Igor V.

“…[Display omitted] •The study of the functions of mPRs requires the ligands that selectively interact only with mPRs.•For the first time, the available…”
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Copper(II)-Mediated Aerobic Synthesis of Imidazo[1,2-a]pyridines via Cascade Aminomethylation/Cycloisomerization of Alkynes by Rassokhina, Irina V, Shirinian, Valerii Z, Zavarzin, Igor V, Gevorgyan, Vladimir, Volkova, Yulia A

“…A single copper(II)-catalyzed three-component cascade aminomethylation/cycloisomerization of propiolates to form imidazo[1,2-a]pyridines was explored. A…”
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Synthesis of Benzothiazole‐ and Benzoxazole‐2‐carboxamides by 2‐Chloracetamides and 2‐Amino(thio)phenols Cyclocondensation with Elemental Sulfur in Water by Kozlov, Mikhail A., Bolshakov, Konstantin M., Kolotyrkina, Natalia G., Zavarzin, Igor V.

“…New straightforward synthesis of benzothiazole‐2‐carboxamides and benzoxazole‐2‐carboxamides from 2‐chloracetamides, 2‐amino(thio)phenols and elemental sulfur…”
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Synthesis of Imidazo[2,1‑b]thiazoles via Copper-Catalyzed A3‑Coupling in Batch and Continuous Flow by Rassokhina, Irina V, Tikhonova, Tatyana A, Kobylskoy, Sergey G, Babkin, Igor Yu, Shirinian, Valerii Z, Gevorgyan, Vladimir, Zavarzin, Igor V, Volkova, Yulia A

“…A straightforward method for the synthesis of functionalized imidazo­[2,1-b]­thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under…”
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General Photoinduced Sequential Electrocyclization/[1,9]-Sigmatropic Rearrangement/Ring-Opening Reaction of Diarylethenes by Lvov, Andrey G, Shirinian, Valerii Z, Zakharov, Alexey V, Krayushkin, Mikhail M, Kachala, Vadim V, Zavarzin, Igor V

“…A novel and efficient photochemical transformation of diarylethenes comprising a five-membered heterocyclic ring and phenyl moiety is described. This reaction…”
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Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells by Scherbakov, Alexander M., Vorontsova, Svetlana K., Khamidullina, Alvina I, Mrdjanovic, Jasminka, Andreeva, Olga E., Bogdanov, Fedor B., Salnikova, Diana I., Jurisic, Vladimir, Zavarzin, Igor V., Shirinian, Valerii Z.

“…The promising antitumor effects of progesterone derivatives have been identified in many studies. However, the specific mechanism of action of this class of…”
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Photoinduced Skeletal Rearrangement of Diarylethenes Comprising Oxazole and Phenyl Rings by Lvov, Andrey G, Shirinian, Valerii Z, Kachala, Vadim V, Kavun, Alexey M, Zavarzin, Igor V, Krayushkin, Mikhail M

“…A novel photochemical rearrangement of diarylethenes bearing oxazole and benzene derivatives as aryl moieties that results in the formation of polyaromatic…”
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Secosteroid–quinoline hybrids as new anticancer agents by Ilovaisky, Alexey I., Scherbakov, Alexander M., Merkulova, Valentina M., Chernoburova, Elena I., Shchetinina, Marina A., Andreeva, Olga E., Salnikova, Diana I., Zavarzin, Igor V., Terent’ev, Alexander O.

“…An elegant approach to unknown secosteroid–quinoline hybrids is disclosed. A series of 13,17-secoestra-1,3,5(10)-trien-17-oic acid…”
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Secosteroid diacylhydrazines as novel effective agents against hormone-dependent breast cancer cells by Ilovaisky, Alexey I., Scherbakov, Alexander M., Chernoburova, Elena I., Shchetinina, Marina A., Merkulova, Valentina M., Bogdanov, Fedor B., Sorokin, Danila V., Salnikova, Diana I., Bozhenko, Eugene I., Zavarzin, Igor V., Terent’ev, Alexander O.

“…This research aimed to develop novel selective secosteroids that are highly active against hormone-dependent breast cancer. A simple and convenient approach to…”
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Photoswitching off the Antiproliferative Activity of Combretastatin A‑4 Analogues by Yadykov, Anton V, Scherbakov, Alexander M, Trofimova, Victoria V, Lvov, Andrey G, Markosyan, Ashot I, Zavarzin, Igor V, Shirinian, Valerii Z

“…The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the…”
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A method for the synthesis of 17-pyrimidinylandrostane by Komkov, Alexander V., Menchikov, Leonid G., Dmitrenok, Andrey S., Zavarzin, Igor V.

“…A convenient synthesis method for new 17-pyrimidinylandrostanes based on 3β-hydroxy-17-[3-dimethylamino)acryloyl]-16α,17α- epoxyandrost-5-ene is proposed. The…”
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Secosteroid thiosemicarbazides and secosteroid–1,2,4-triazoles as antiproliferative agents targeting breast cancer cells: Synthesis and biological evaluation by Ilovaisky, Alexey I., Scherbakov, Alexander M., Chernoburova, Elena I., Povarov, Andrey A., Shchetinina, Marina A., Merkulova, Valentina M., Salnikova, Diana I., Sorokin, Danila V., Bozhenko, Eugene I., Zavarzin, Igor V., Terent’ev, Alexander O.

“…A convenient and selective approach to 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N’-arylcarbothioamido]hydrazides and hybrid molecules containing…”
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Synthesis of 17-(1,2,3-dithiazole) androstene derivatives by Amelichev, Stanislav A., Shashkov, Alexander S., Zavarzin, Igor V., Rakitin, Oleg A.

“…17-(1,2,3-Dithiazole) androstene derivatives were synthesized from commercially available Pregnenolone acetate involving the reaction between…”
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Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents by Ilovaisky, Alexey I., Merkulova, Valentina M., Chernoburova, Elena I., Shchetinina, Marina A., Salnikova, Diana I., Scherbakov, Alexander M., Zavarzin, Igor V., Terent’ev, Alexander O.

“…[Display omitted] •A selective approach to antitumor agents based on the opening of ring D in steroidal lactones by hydrazines was developed.•Secosteroidal…”
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