Search Results - "V. S. Prassolov"

Activated leukemic oncogenes AML1-ETO and c-kit: Role in development of acute myeloid leukemia and current approaches for their inhibition by Rulina, A. V, Spirin, P. V, Prassolov, V. S

“…Acute myeloid leukemia (AML) is a malignant blood disease caused by different mutations that enhance the pro-liferative activity and survival of blood cells…”
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Regulation of Human Adenovirus Replication by RNA Interference by Nikitenko, N A, Speiseder, T, Lam, E, Rubtsov, P M, Tonaeva, Kh D, Borzenok, S A, Dobner, T, Prassolov, V S

“…Adenoviruses cause a wide variety of human infectious diseases. Adenoviral conjunctivitis and epidemic keratoconjunctivitis are commonly associated with human…”
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Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways by Ivanenko, K. A., Prassolov, V. S., Khabusheva, E. R.

“…Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell…”
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Organization and regulation of nucleocytoplasmic transport by Chumakov, S. P, Prassolov, V. S

“…Separation of DNA replication and transcription, which occur in the nucleus, from protein synthesis, which occurs in the cytoplasm, allows a more precise…”
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Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling by Spirin, P V, Lebedev, T D, Orlova, N N, Gornostaeva, A S, Prokofjeva, M M, Nikitenko, N A, Dmitriev, S E, Buzdin, A A, Borisov, N M, Aliper, A M, Garazha, A V, Rubtsov, P M, Stocking, C, Prassolov, V S

“…The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding…”
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Plasmolipin and Its Role in Cell Processes by Shulgin, A. A., Lebedev, T. D., Prassolov, V. S., Spirin, P. V.

“…The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task…”
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5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia by Novikova, O N, Matyugina, E S, Gorshenin, A V, Velikorodnaya, Yu I, Krengauz, M D, Vedernikova, V O, Spirin, P V, Prassolov, V S, Kochetkov, S N, Khandazhinskaya, A L

“…5'-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC50 for the Jurkat, K562, and…”
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The Different Impact of ERK Inhibition on Neuroblastoma, Astrocytoma, and Rhabdomyosarcoma Cell Differentiation by Lebedev, T D, Vagapova, E R, Prassolov, V S

“…Aberrant ERK activity can lead to uncontrolled cell proliferation, immortalization, and impaired cell differentiation. Impairment of normal cell…”
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The Role of Autophagy in the Development of Pathological Conditions of the Body by Kench, U S, Sologova, S S, Prassolov, V S, Spirin, P V

“…Autophagy is the process of lysosomal elimination of the cell organelles, cytoplasmic sites, and pathogenic microorganisms that enter the cell. This process is…”
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Activated leukemic oncogenes responsible for neoplastic transformation of hematopoietic cells by Baskaran, D, Spirin, P. V, Prassolov, V. S

“…Leukemias are a heterogeneous group of malignant blood diseases that are characterized by expansion of immature blast cells. The point molecular mechanisms of…”
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The Role of TAL1 in Hematopoiesis and Leukemogenesis by Vagapova, E R, Spirin, P V, Lebedev, T D, Prassolov, V S

“…TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates…”
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Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms by Vilgelm, A. E, Zaika, A. I, Prassolov, V. S

“…For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the…”
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Therapy of HIV Infection: Current Approaches and Prospects by Prokofjeva, M M, Kochetkov, S N, Prassolov, V S

“…The human immunodeficiency virus type 1 (HIV-1) is the causative agent of one of the most dangerous human diseases - the acquired immune deficiency syndrome…”
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The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation by Shyrokova, Elena Yu, Prassolov, Vladimir S., Spirin, Pavel V.

“…The mutations associated with malignant cell transformation are believed to disrupt the expression of a significant number of normal, non-mutant genes. The…”
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Lentiviral gene delivery to plasmolipin-expressing cells using Mus caroli endogenous retrovirus envelope protein by Prokofjeva, M.M., Proshkina, G.M., Lebedev, T.D., Shulgin, A.A., Spirin, P.V., Prassolov, V.S., Deyev, S.M.

“…Gene therapy is a promising method for treating malignant diseases. One of the main problems is target delivery of therapeutic genes. Here we show that…”
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Inhibition of Non-Receptor Tyrosine Kinase JAK2 Reduces Neuroblastoma Cell Growth and Enhances the Action of Doxorubicin by Lebedev, T. D., Vagapova, E. R., Astashkova, O. O., Spirin, P. V., Prassolov, V. S.

“…—Novel treatments for various types of malignant diseases are warranted. In this study, we evaluated JAK2 inhibitors (Janus kinase 2) for suppressing the…”
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Packaging of Subchromosomal-Size DNA Molecules in Chromatin Bodies in the Ciliate Macronucleus by Leonova, O. G., Potekhin, A. A., Nekrasova, I. V., Karajan, B. P., Syomin, B. V., Prassolov, V. S., Popenko, V. I.

“…A fundamental difference between somatic nuclei (macronuclei) of ciliates and cell nuclei of higher eukaryotes is that the macronuclear genome is a huge number…”
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Downregulation of activated leukemic oncogenes AML1-ETO and RUNX1(K83N) expression with RNA-interference by Spirin, P. V, Baskaran, D, Orlova, N. N, Rulina, A. V, Nikitenko, N. A, Chernolovskaya, E. L, Zenkova, M. A, Vlassov, V. V, Rubtsov, P. M, Chumakov, P. M, Stocking, C, Prassolov, V. S

“…In the present study, we have applied the siRNA approach to reduce the expression of AML1-ETO and RUNX1(K83N) oncogenes, which are frequently found in leukemic…”
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High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin by Vagapova, E R, Lebedev, T D, Tikhonova, A D, Goikhman, B V, Ivanenko, K A, Spirin, P V, Prassolov, V S

“…Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat…”
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Non-Viral Delivery and Therapeutic Application of Small Interfering RNAs by Nikitenko, N A, Prassolov, V S

“…RNA interference (RNAi) is a powerful method used for gene expression regulation. The increasing knowledge about the molecular mechanism of this phenomenon…”
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