Search Results - "V. Parchenko"

Some transformations in a series of 4-amino-1,2,4-triazole-3-thion derivatives by Bihdan, O. A., Parchenko, V. V., Gutyj, B. V.

“…The continuous improvement of synthesis methods enables the optimization of the process for developing and obtaining target products of chemical…”
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Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review) by Khilkovets, A. V., Parchenko, V. V.

“…In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous…”
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The results of determining the indicators of the morphological composition of the blood of animals and individual biochemical indicators using a potential drug with a mixture of two active compounds: 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine and 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol in milk thistle seed oil by Ohloblina, M. V., Bushuieva, I V., Parchenko, V. V.

“…The introduction of new domestic highly effective and safe medicines into medical and veterinary practice is an important task of modern pharmaceutical…”
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Analysis of the domestic market of 1,2,4-triazole-containing drugs by Ohloblina, M. V., Bushuieva, I. V., Parchenko, V. V.

“…The modern market of medicines in Ukraine has the dynamics of constant development. At the same time, the dynamics of the pharmaceutical market depend entirely…”
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Study of mutagenic effects with predicted carcinogenicity of 4-((5-decylthio)-4-methyl-4-H-1,2,4-triazole-3-yl)methyl)morpholine for further research in order to create a new drug with antifungal activity by Bushuieva, I. V., Petrova, K. V., Kyrychko, B. P., Parchenko, V. V.

“…The development of effective and safe therapeutic agents using 1,2,4-triazole derivatives is gaining momentum in today’s conditions. The value of such drugs is…”
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The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols by Karpun, Ye. O., Borsuk, S. O., Kucherenko, L. I., Parchenko, V. V.

“…About half of the drugs currently produced are chiral compounds, and about 90 % of these compounds are sold as racemates, consisting of an equimolar mixture of…”
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Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments by Bihdan, O. A., Parchenko, V. V., Kyrychko, B. P., Zvenyhorodska, T. V., Romanina, D. M.

“…Diuretics increase the volume of urine and sodium excretion, and therefore are often used to remove excess fluid from the body during various diseases,…”
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Toxicity parameters of a new 1,2,4-triazole derivative when subcutaneously injected to guinea pigs by Zazharskyi, V. V., Bigdan, O. A., Parchenko, V. V., Karpenko, Y. V., Zazharska, N. M., Mykhailiuk, Y. O., Kulishenko, O. M., Davydenko, P. O., Kulish, S. M., Gutyj, B. V.

“…The results of the literature analysis indicate a wide spectrum of biological activity of 1,2,4-triazole derivatives. Low toxicity, reactivity, and high…”
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Express quantitative spectrophotometric determination of 2-(((3-(2-fluorophenyl)- 5-thio-4H-1,2,4-triazol-4-yl)imino)methyl)phenol as an active substance of a medicinal product for the treatment of mycoses by Miedviedieva, K. P., Prytula, R. L., Shmatenko, O. P., Bushuieva, I. V., Parchenko, V. V., Kucherenko, L. I., Vasiuk, S. O.

“…Foot fungus (Candida, molds, dermatophytes) is a fairly common problem. According to the WHO, one-fifth of the world’s population is affected by fungal skin…”
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Parasitofauna of farm red deer (Cervus elaphus) in Western Polissya of Ukraine by Hunchak, Yu. R., Yuskiv, I. D., Gutyj, B. V., Hunchak, A. V., Parchenko, V. V.

“…The formation of the parasite fauna of wild ungulates and control of diseases caused by them is an essential veterinary measure in the breeding of deer. The…”
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Potentiometric Sensor for Naproxen Determination by Kormosh, Zh, Kormosh, N., Bokhan, Yu, Gorbatyuk, N., Kotsan, I., Suprunovich, S., Parchenko, V., Savchuk, T., Korolchuk, S.

“…Anaproxen-sensitive potentiometric sensor with a plasticized PVC membrane was designed. The sensor contains an ion associate of naproxen with rhodamine 6G dye…”
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Synthesis and physical-chemical properties of some 5-(3-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiol derivatives by Bihdan, O. A., Parchenko, V. V.

“…There are engaged scientists practically from all over the world to the 1,2,4-triazole system research but the greatest attention deserve the achievements of…”
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Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum by Gutyj, B. V., Martyshuk, T. V., Parchenko, V. V., Kaplaushenko, A. H., Bushueva, I. V., Hariv, I. I., Bilash, Y. P., Brygadyrenko, V. V., Turko, Y. I., Radzykhovskyi, M. L.

“…The balance between anti- and prooxidants in animal organisms in general and in each cell in particular is responsible for the regulation of many metabolic…”
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Experimental assessment of the toxicity of a cardiac drug based on a phosphodiesterase-3 inhibitor and ethylmethylhydroxypyridine succinate by Varkholiak, I. S., Gutyj, B. V., Zolototska, O. B., Goralskyi, L. P., Sokulskyi, I. M., Khalak, V. I., Parchenko, V. V., Shcherbatyy, A. R., Martyshuk, T. V., Guta, Z. A.

“…The study aimed to establish the parameters of chronic toxicity of the newly developed drug based on phosphodiesterase-3 inhibitor and…”
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In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives by Karpun, Ye. O., Karpenko, Yu. V., Parchenko, V. V., Panasenko, O. I.

“…A combination of two rings of 1,2,4-triazole with the formation of new hybrids, bis-1,2,4-triazoles, with various functional groups and pharmacophores may…”
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Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles by Bihdan, O. A., Parchenko, V. V.

“…Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic…”
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Acute toxicity of 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives by Danilchenko, D. M., Parchenko, V. V.

“…The purpose of our work was the further exploration of the new 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives’ acute…”
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Impact of 1,2,4-thio-triazole derivative-based liniment on morphological and immunological blood parameters of dogs suffering from dermatomycoses by V. M. Hunchak, V. P. Martynyshyn, B. V. Gutyj, A. V. Hunchak, O. M. Stefanyshyn, V. V. Parchenko

“…The development of new preparations in soft medical form with antifungal effect and the ability to exert an antimicrobial effect on the secondary microflora…”
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Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives by Bihdan, O. A., Parchenko, V. V.

“…Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular…”
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Anticancer properties of 1,2,4-triazole derivatives (literature review) by Bushuieva, I. V., Parchenko, M. V.

“…Cancer is still one of the leading causes of death worldwide. Statistical data show that more than 130,000 people in Ukraine receive this diagnosis as a…”
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