MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION

Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparat...

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Bibliographic Details
Published in:	Acta biomedica scientifica no. 3(2); pp. 264 - 266
Main Authors:	S. G. Gamaley, A. V. Bateneva, Z. F. Urmantseva, G. M. Sisoyeva, Ya. V. Markus, E. D. Danilenko, V. K. Mikhaylova, E. A. Volosnikova, G. M. Levagina, V. I. Masicheva
Format:	Journal Article
Language:	Russian
Published:	Scientific Сentre for Family Health and Human Reproduction Problems 01-05-2012
Subjects:	polyethylene glycol rheopolyglukin tnf-α tumor necrosis factor alpha
Online Access:	Get full text
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Summary:	Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals.
ISSN:	2541-9420 2587-9596