Search Results - "V. Bazhin, Alexandr"
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Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy
Published in Journal of cellular physiology (01-12-2016)“…Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell signaling. Mitochondria in malignant cells differ structurally and…”
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2
Reactive oxygen species and colorectal cancer
Published in Journal of cellular physiology (01-07-2018)“…Colorectal cancer (CRC) has become the fourth leading cause of cancer‐related death in the worldwide. It is urgent to find more effective therapeutic…”
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3
The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases
Published in Journal of gastrointestinal surgery (01-03-2022)“…Background Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty (NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting…”
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4
Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling
Published in Frontiers in immunology (27-09-2018)“…Interferon-α (IFNα) has one of the longest histories of use amongst cytokines in clinical oncology and has been applied for the treatment of many types of…”
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Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer
Published in Frontiers in immunology (07-08-2018)“…Novel therapies targeting immune checkpoint molecules have redefined the treatment of cancer at advanced stages and brought hope to millions of patients…”
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The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies
Published in Frontiers in oncology (10-11-2021)“…Despite recent advancements in the treatment of hematologic malignancies and the emergence of newer and more sophisticated therapeutic approaches such as…”
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Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
Published in Proceedings of the National Academy of Sciences - PNAS (11-10-2011)“…Tumor microenvironment is characterized by chronic inflammation represented by infiltrating leukocytes and soluble mediators, which lead to a local and…”
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CD96 as a Potential Immune Regulator in Cancers
Published in International journal of molecular sciences (09-01-2023)“…The discovery of CTLA-4 and PD-1 checkpoints has prompted scientific researchers and the pharmaceutical industry to develop and conduct extensive research on…”
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9
PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia
Published in BMC cancer (16-05-2023)“…Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors…”
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10
The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives
Published in Frontiers in oncology (14-01-2021)“…Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated…”
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11
Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting
Published in Cancers (05-03-2020)“…Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of…”
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12
TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1
Published in BMC cancer (24-01-2024)“…T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed…”
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13
Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
Published in Oxidative medicine and cellular longevity (01-01-2019)“…Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their…”
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14
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation
Published in Frontiers in immunology (22-07-2020)“…Among the various immunological and non-immunological tumor-promoting activities of myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity…”
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15
The Role of TIM-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy?
Published in Frontiers in oncology (03-12-2020)“…One of the most common tumors in the world is hepatocellular carcinoma (HCC), and its mortality rates are still on the rise, so addressing it is considered an…”
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Myeloid-Derived Suppressor Cells in Solid Tumors
Published in Cells (Basel, Switzerland) (17-01-2022)“…Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of…”
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The Sabotaging Role of Myeloid Cells in Anti‐Angiogenic Therapy: Coordination of Angiogenesis and Immune Suppression by Hypoxia
Published in Journal of cellular physiology (01-09-2017)“…Tumor angiogenesis has become a promising target for anti‐tumor therapy. Unfortunately, the somewhat inevitable occurrence of resistance has limited the…”
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The predictive value of tumor infiltrating leukocytes in Hepatocellular Carcinoma: A systematic review and meta-analysis
Published in European journal of surgical oncology (01-10-2021)“…For Hepatocellular carcinoma (HCC) surgery either through resection or transplantation often provides the only chance for cure. Since hepatocarcinogenesis and…”
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Two immune faces of pancreatic adenocarcinoma: possible implication for immunotherapy
Published in Cancer Immunology, Immunotherapy (01-01-2014)“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human neoplasms, having extremely poor prognosis with a 5-year survival rate of <1 % and…”
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NOP2-mediated m5C Modification of c-Myc in an EIF3A-Dependent Manner to Reprogram Glucose Metabolism and Promote Hepatocellular Carcinoma Progression
Published in Research (Washington) (2023)“…Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular carcinoma (HCC). NOP2 is an S-adenosyl-L-methionine-dependent…”
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