Search Results - "V. Bazhin, Alexandr"

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy by Yang, Yuhui, Karakhanova, Svetlana, Hartwig, Werner, D'Haese, Jan G., Philippov, Pavel P., Werner, Jens, Bazhin, Alexandr V.

“…Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell signaling. Mitochondria in malignant cells differ structurally and…”
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Reactive oxygen species and colorectal cancer by Lin, Sisi, Li, Yongyu, Zamyatnin, Andrey A., Werner, Jens, Bazhin, Alexandr V.

“…Colorectal cancer (CRC) has become the fourth leading cause of cancer‐related death in the worldwide. It is urgent to find more effective therapeutic…”
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The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases by An, Lingxuan, Wirth, Ulrich, Koch, Dominik, Schirren, Malte, Drefs, Moritz, Koliogiannis, Dionysios, Nieß, Hanno, Andrassy, Joachim, Guba, Markus, Bazhin, Alexandr V., Werner, Jens, Kühn, Florian

“…Background Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty (NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting…”
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Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling by Bazhin, Alexandr V, von Ahn, Katharina, Fritz, Jasmin, Werner, Jens, Karakhanova, Svetlana

“…Interferon-α (IFNα) has one of the longest histories of use amongst cytokines in clinical oncology and has been applied for the treatment of many types of…”
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Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer by Shevchenko, Ivan, Bazhin, Alexandr V

“…Novel therapies targeting immune checkpoint molecules have redefined the treatment of cancer at advanced stages and brought hope to millions of patients…”
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The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies by Soltani, Mojdeh, Zhao, Yue, Xia, Zhijia, Ganjalikhani Hakemi, Mazdak, Bazhin, Alexandr V.

“…Despite recent advancements in the treatment of hematologic malignancies and the emergence of newer and more sophisticated therapeutic approaches such as…”
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Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model by Meyer, Christiane, Sevko, Alexandra, Ramacher, Marcel, Bazhin, Alexandr V, Falk, Christine S, Osen, Wolfram, Borrello, Ivan, Kato, Masashi, Schadendorf, Dirk, Baniyash, Michal, Umansky, Viktor

“…Tumor microenvironment is characterized by chronic inflammation represented by infiltrating leukocytes and soluble mediators, which lead to a local and…”
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CD96 as a Potential Immune Regulator in Cancers by Feng, Shikai, Isayev, Orkhan, Werner, Jens, Bazhin, Alexandr V

“…The discovery of CTLA-4 and PD-1 checkpoints has prompted scientific researchers and the pharmaceutical industry to develop and conduct extensive research on…”
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PD-L1 stimulation can promote proliferation and survival of leukemic cells by influencing glucose and fatty acid metabolism in acute myeloid leukemia by Soltani, Mojdeh, Ghanadian, Mustafa, Ghezelbash, Behrooz, Shokouhi, Abolfazl, Zamyatnin, Jr, Andrey A, Bazhin, Alexandr V, Ganjalikhani-Hakemi, Mazdak

“…Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors…”
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The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives by Wu, Yang, Zhang, Chun, Jiang, Kuirong, Werner, Jens, Bazhin, Alexandr V, D'Haese, Jan G

“…Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated…”
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Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting by Baldin, Alexey V, Savvateeva, Lyudmila V, Bazhin, Alexandr V, Zamyatnin, Jr, Andrey A

“…Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of…”
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TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1 by Shapourian, Hooriyeh, Ghanadian, Mustafa, Eskandari, Nahid, Shokouhi, Abolfazl, Demirel, Gülderen Yanikkaya, Bazhin, Alexandr V, Ganjalikhani-Hakemi, Mazdak

“…T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed…”
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Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease by Bazhin, Alexandr V., Strippoli, Raffaele, Sánchez-Álvarez, Miguel, Cordani, Marco, Donadelli, Massimo

“…Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their…”
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Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation by Yang, Yuhui, Li, Chunyan, Liu, Tao, Dai, Xiaofang, Bazhin, Alexandr V

“…Among the various immunological and non-immunological tumor-promoting activities of myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity…”
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The Role of TIM-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy? by Ganjalikhani Hakemi, Mazdak, Jafarinia, Morteza, Azizi, Mahdieh, Rezaeepoor, Mahsa, Isayev, Orkhan, Bazhin, Alexandr V

“…One of the most common tumors in the world is hepatocellular carcinoma (HCC), and its mortality rates are still on the rise, so addressing it is considered an…”
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Myeloid-Derived Suppressor Cells in Solid Tumors by Ma, Tianmiao, Renz, Bernhard W, Ilmer, Matthias, Koch, Dominik, Yang, Yuhui, Werner, Jens, Bazhin, Alexandr V

“…Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of…”
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The Sabotaging Role of Myeloid Cells in Anti‐Angiogenic Therapy: Coordination of Angiogenesis and Immune Suppression by Hypoxia by Li, Chunyan, Liu, Tao, Bazhin, Alexandr V., Yang, Yuhui

“…Tumor angiogenesis has become a promising target for anti‐tumor therapy. Unfortunately, the somewhat inevitable occurrence of resistance has limited the…”
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The predictive value of tumor infiltrating leukocytes in Hepatocellular Carcinoma: A systematic review and meta-analysis by Schoenberg, Markus Bo, Li, Xiaokang, Li, Xinyu, Han, Yongsheng, Hao, Jingcheng, Miksch, Rainer Christoph, Koch, Dominik, Börner, Nikolaus, Beger, Nicola Theresa, Bucher, Julian Nikolaus, Schiergens, Tobias Simon, Guba, Markus Otto, Werner, Jens, Bazhin, Alexandr V.

“…For Hepatocellular carcinoma (HCC) surgery either through resection or transplantation often provides the only chance for cure. Since hepatocarcinogenesis and…”
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Two immune faces of pancreatic adenocarcinoma: possible implication for immunotherapy by Bazhin, Alexandr V., Shevchenko, Ivan, Umansky, Viktor, Werner, Jens, Karakhanova, Svetlana

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human neoplasms, having extremely poor prognosis with a 5-year survival rate of <1 % and…”
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NOP2-mediated m5C Modification of c-Myc in an EIF3A-Dependent Manner to Reprogram Glucose Metabolism and Promote Hepatocellular Carcinoma Progression by Zhang, Hao, Zhai, Xiangyu, Liu, Yanfeng, Xia, Zhijia, Xia, Tong, Du, Gang, Zhou, Huaxin, Franziska Strohmer, Dorothee, Bazhin, Alexandr V, Li, Ziqiang, Wang, Xianqiang, Jin, Bin, Guo, Deliang

“…Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular carcinoma (HCC). NOP2 is an S-adenosyl-L-methionine-dependent…”
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