Search Results - "V Strushkevich, Natallia"
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Compound I Is the Reactive Intermediate in the First Monooxygenation Step during Conversion of Cholesterol to Pregnenolone by Cytochrome P450scc: EPR/ENDOR/Cryoreduction/Annealing Studies
Published in Journal of the American Chemical Society (17-10-2012)“…Cytochrome P450scc (CYP11A1) catalyzes conversion of cholesterol (CH) to pregnenolone, the precursor to all steroid hormones. This process proceeds via three…”
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Bielectrode Strategy for Determination of CYP2E1 Catalytic Activity: Electrodes with Bactosomes and Voltammetric Determination of 6-Hydroxychlorzoxazone
Published in Biomedicines (01-01-2024)“…We describe a bielectrode system for evaluation of the electrocatalytic activity of cytochrome P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the…”
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Insights into Ergosterol Peroxide's Trypanocidal Activity
Published in Biomolecules (Basel, Switzerland) (12-09-2019)“…, which causes Chagas disease, is a significant health threat in many countries and affects millions of people. Given the magnitude of this disease, a broader…”
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Molecular identification of adrenal inner zone antigen as a heme‐binding protein
Published in The FEBS journal (01-11-2005)“…The adrenal inner zone antigen (IZA), which reacts specifically with a monoclonal antibody raised against the fasciculata and reticularis zones of the rat…”
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Electrochemical oxidation of estrogens as a method for CYP19A1 (aromatase) electrocatalytic activity determination
Published in Electrochimica acta (10-02-2020)“…In this study we present an original approach for determination of electrocatalytic activity of CYP19A1 (aromatase), immobilized on screen-printed graphite…”
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A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners
Published in Biochimie (01-07-2019)“…The aim of the present work was to establish the thermodynamic and functional differences in the protein-protein interactions between the components of the…”
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New azole derivatives of [17(20)E]-21-norpregnene: Synthesis and inhibition of prostate carcinoma cell growth
Published in Steroids (01-07-2019)“…[Display omitted] A number of isoxazole, 1,2,3-triazole, tetrazole, and 1,2,4-oxadiazole derivatives of [17(20)E]-21-norpregnene comprising 3β-hydroxy-5-ene…”
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In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug–drug interactions
Published in Fundamental & clinical pharmacology (01-02-2020)“…Potential drug–drug interactions of the antitumor drug abiraterone and the macrolide antibiotic erythromycin were studied at the stage of cytochrome P450 3A4…”
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Human steroid and oxysterol 7α‐hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants
Published in The FEBS journal (01-03-2014)“…Oxysterols and neurosteroids are important signaling molecules produced by monooxygenases of the cytochrome P450 family that realize their effect through…”
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Human steroid and oxysterol 7[alpha]-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants
Published in The FEBS journal (01-03-2014)“…Oxysterols and neurosteroids are important signaling molecules produced by monooxygenases of the cytochrome P450 family that realize their effect through…”
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Human steroid and oxysterol 7α‐hydroxylase CYP 7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants
Published in The FEBS journal (01-03-2014)“…Oxysterols and neurosteroids are important signaling molecules produced by monooxygenases of the cytochrome P450 family that realize their effect through…”
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