Search Results - "Vélez‐Reyes, Germán L."

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung by Danahay, Henry, Pessotti, Angelica D., Coote, Julie, Montgomery, Brooke E., Xia, Donghui, Wilson, Aaron, Yang, Haidi, Wang, Zhao, Bevan, Luke, Thomas, Chris, Petit, Stephanie, London, Anne, LeMotte, Peter, Doelemeyer, Arno, Vélez-Reyes, Germán L., Bernasconi, Paula, Fryer, Christy J., Edwards, Matt, Capodieci, Paola, Chen, Amy, Hild, Marc, Jaffe, Aron B.

“…The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling,…”
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R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers by Conboy, Caitlin B, Vélez-Reyes, Germán L, Rathe, Susan K, Abrahante, Juan E, Temiz, Nuri A, Burns, Michael B, Harris, Reuben S, Starr, Timothy K, Largaespada, David A

“…Wnt signaling is activated in many cancer types, yet targeting the canonical Wnt pathway has been challenging for cancer therapy. The pathway might be…”
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R‐spondin 2 Drives Liver Tumor Development in a Yes‐Associated Protein‐Dependent Manner by Conboy, Caitlin B., Vélez‐Reyes, Germán L., Tschida, Barbara R., Hu, Hsiangyu, Kaufmann, Gabriel, Koes, Nicholas, Keller, Bryant, Alsinet, Clara, Cornellà, Helena, Pinyol, Roser, Abrahante, Juan E., Temiz, Nuri A., Linden, Michael A., Amin, Khalid, Kuka, Timothy P., Keng, Vincent W., Llovet, Josep M., Starr, Timothy K., Largaespada, David A.

“…Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death…”
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HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients by Rivera-Peña, Bianca, Ruíz-Fullana, Francisco J, Vélez-Reyes, Germán L, Rodriguez-Benitez, Rosa J, Marcos-Martínez, María J, Trinidad-Pinedo, Juan, Báez, Adriana

“…HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16…”
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Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities by Suppiah, Suganth, Mansouri, Sheila, Mamatjan, Yasin, Liu, Jeffrey C., Bhunia, Minu M., Patil, Vikas, Rath, Prisni, Mehani, Bharati, Heir, Pardeep, Bunda, Severa, Velez-Reyes, German L., Singh, Olivia, Ijad, Nazanin, Pirouzmand, Neda, Dalcourt, Tatyana, Meng, Ying, Karimi, Shirin, Wei, Qingxia, Nassiri, Farshad, Pugh, Trevor J., Bader, Gary D., Aldape, Kenneth D., Largaespada, David A., Zadeh, Gelareh

“…Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress…”
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Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development by Vélez-Reyes, Germán L, Koes, Nicholas, Ryu, Ji Hae, Kaufmann, Gabriel, Berner, Mariah, Weg, Madison T, Wolf, Natalie K, Rathe, Susan K, Ratner, Nancy, Moriarity, Branden S, Largaespada, David A

“…Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, genomically complex, have soft tissue sarcomas, and are derived from the Schwann cell…”
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Identification and Characterization of Candidate Oncogenes and Tumor Suppressor Genes in Hepatocellular Carcinoma and Peripheral Neural Sheath Tumors by Vélez Reyes, Germán L

“…Cancer is a devastating and intriguing disease. Innovations in screening and treatment have reduced cancer rates and mortality in the last decade. However, we…”
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Abstract 3737: Identifying novel therapeutic targets for cancer stem cell differentiation by Reyes, Germán L. Vélez, Yang, Haidi, Wilson, Aaron, Henault, Martin, Frias, Elizabeth, Schlabach, Michael, Mclaughlin, Margaret, Ross, Nathan, Hoffman, Gregory, Chen, Amy, Hild, Marc, Jaffe, Aron

“…Abstract A growing body of evidence supports a role for cancer stem cells in the initiation and maintenance of a wide range of tumors. Cancer stem cells appear…”
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Abstract 337: HPV16 infection plays a significant role in laryngeal carcinogenesis among Puerto Ricans by Vélez-Reyes, Germán L., Ruiz-Fullana, Francisco J., García, Aurian, Trinidad-Pinedo, Juan, Baez, Adriana

“…Abstract Aims: Incidence of head and neck cancer (HNSCC) has increased in the past decades in younger adults. Oncogenic proteins E6 and E7 in HPV 16 are known…”
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Multiomic Analyses Reveal New Targets of Polycomb Repressor Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors by Bhunia, Minu M, Stehn, Christopher M, Jubenville, Tyler A, Novacek, Ethan L, Larsson, Alex T, Madala, Mahathi, Suppiah, Suganth, Velez-Reyes, Germán L, Williams, Kyle B, Sokolowski, Mark, Williams, Rory L, Finnerty, Samuel J, Temiz, Nuri A, Caride, Ariel, Bhagwate, Aditya V, Nagaraj, Nagaswaroop K, Lee, Jeong-Heon, Ordog, Tamas, Zadeh, Gelareh, Largaespada, David A

“…Abstract Background Malignant peripheral nerve sheath tumors (MPNST) can arise from atypical neurofibromas (ANF). Loss of the polycomb repressor complex 2…”
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Abstract LB-197: Transposon mutagenesis and CRISPR/Cas9 screening reveal pathways driving peripheral nerve sheath tumor development and maintenance by Reyes, German L. Velez, Koes, Nicholas, Kaufmann, Gabriel, Ryu, Esther, Largaespada, David A.

“…Abstract Malignant Peripheral Nerve Sheath tumors(MPNSTs) are highly aggressive soft tissue sarcomas derived Schwann cell tumors. Half of these tumors occur…”
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