Search Results - "Végh, Attila G"
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Cytotoxic CD8⁺ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons
Published in Proceedings of the National Academy of Sciences - PNAS (05-02-2019)“…Adaptive immune response is part of the dynamic changes that accompany motoneuron loss in amyotrophic lateral sclerosis (ALS). CD4+ T cells that regulate a…”
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2
Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases
Published in Journal of Cerebral Blood Flow & Metabolism (01-04-2018)“…Despite the potential obstacle represented by the blood–brain barrier for extravasating malignant cells, metastases are more frequent than primary tumors in…”
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Book Review Journal Article -
3
DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila
Published in PLoS genetics (01-02-2014)“…During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function. Although…”
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Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes
Published in Brain, behavior, and immunity (01-08-2017)“…Highlights • Brain pericytes express NOD-like and Toll-like pattern recognition receptors. • Expression of NLRs and TLRs is regulated by inflammatory…”
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Sustained maternal smoking-associated changes in the physico-chemical properties of fetal RBC membranes might serve as early markers for vascular comorbidities
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-04-2020)“…Maternal smoking-induced congenital heart and microvascular defects are closely associated with the impaired functioning of the in-utero feto-placental…”
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6
Breast adenocarcinoma-derived exosomes lower first-contact de-adhesion strength of adenocarcinoma cells to brain endothelial layer
Published in Colloids and surfaces, B, Biointerfaces (01-08-2021)“…[Display omitted] •Breast adenocarcinoma- brain endothelial de-adhesion dynamics is presented.•Adenocarcinoma-derived exosomes alter de-adhesion pattern of…”
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Failure in the compensatory mechanism in red blood cells due to sustained smoking during pregnancy
Published in Chemico-biological interactions (01-11-2019)“…Decrease in the bioavailability of vasoactive nitric oxide (NO), derived from the endothelial nitric oxide synthase (NOS3), underlines vascular endothelial…”
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Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension
Published in Frontiers in physiology (15-05-2018)“…The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In…”
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9
Improving dental epithelial junction on dental implants with bioengineered peptides
Published in Frontiers in bioengineering and biotechnology (2023)“…The functionalization of titanium (Ti) and titanium alloys (Ti6Al4V) implant surfaces via material-specific peptides influence host/biomaterial interaction…”
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10
De-adhesion dynamics of melanoma cells from brain endothelial layer
Published in Biochimica et biophysica acta. General subjects (01-03-2018)“…Metastasis formation is a complex and not entirely understood process. The poorest prognosis and the most feared complications are associated to brain…”
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11
Double-stranded RNA attenuates the barrier function of human pulmonary artery endothelial cells
Published in PloS one (03-06-2013)“…Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical…”
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12
Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K
Published in Cell adhesion & migration (03-05-2016)“…Brain metastases are common and devastating complications of both breast cancer and melanoma. Although mammary carcinoma brain metastases are more frequent…”
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13
Role of Rho/ROCK signaling in the interaction of melanoma cells with the blood-brain barrier
Published in Pigment cell and melanoma research (01-01-2014)“…Summary We have investigated the role of the Rho/ROCK signaling pathway in the interaction of metastatic melanoma cells with the brain endothelium. ROCK…”
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14
Interaction of cysteine-rich cationic antimicrobial peptides with intact bacteria and model membranes
Published in General physiology and biophysics (01-04-2015)“…Antimicrobial peptides are small proteins that exhibit a broad spectrum of antimicrobial activity. Their chemical structure allows them to interact (attach and…”
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15
Breast adenocarcinoma cells adhere stronger to brain pericytes than to endothelial cells
Published in Colloids and surfaces, B, Biointerfaces (01-02-2024)“…Most of the malignancies detected within the brain parenchyma are of metastatic origin. As the brain lacks classical lymphatic circulation, the primary way for…”
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16
Direct mapping of melanoma cell ‐ endothelial cell interactions
Published in Journal of molecular recognition (01-06-2017)“…The most life‐threatening aspect of cancer is metastasis; cancer patient mortality is mainly due to metastasis. Among all metastases, presence of brain…”
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Elasto-mechanical properties of living cells
Published in Biochemistry and biophysics reports (01-09-2016)“…The possibility to directly measure the elasticity of living cell has emerged only in the last few decades. In the present study the elastic properties of two…”
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Adhesion and stress relaxation forces between melanoma and cerebral endothelial cells
Published in European biophysics journal (01-02-2012)“…Mechanical parameters play a crucial role in proper cellular functions. This article examines the process of the appearance and breaking of adhesion forces…”
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19
Spatial and temporal dependence of the cerebral endothelial cells elasticity
Published in Journal of molecular recognition (01-05-2011)“…The reliable determination of the mechanical properties of a living cell is one of the most important challenges of the atomic force microscopic measurements…”
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20
Pituitary adenylate cyclase activating polypeptide acts against neovascularization in retinal pigment epithelial cells
Published in Annals of the New York Academy of Sciences (01-11-2019)“…The purpose of this study was to determine whether pituitary adenylate cyclase activating polypeptide (PACAP) could influence the neovascularization processes…”
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