Search Results - "Vécsei, Laszló"

Therapeutic Approaches for Peripheral and Central Neuropathic Pain by Vécsei, László, Nyári, Aliz, Tajti, János, Szok, Délia

“…Neuropathic pain is a chronic secondary pain condition, which is a consequence of peripheral or central nervous (somatosensory) system lesions or diseases. It…”
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Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan-Kynurenine Metabolic System by Tanaka, Masaru, Szabó, Ágnes, Spekker, Eleonóra, Polyák, Helga, Tóth, Fanni, Vécsei, László

“…Nearly half a century has passed since the discovery of cytoplasmic inheritance of human chloramphenicol resistance. The inheritance was then revealed to take…”
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Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain by Tajti, János, Szok, Délia, Csáti, Anett, Szabó, Ágnes, Tanaka, Masaru, Vécsei, László

“…Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which exhibit some symptom similarities and are thus considered to share a…”
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Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway by Tanaka, Masaru, Tóth, Fanni, Polyák, Helga, Szabó, Ágnes, Mándi, Yvette, Vécsei, László

“…The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is…”
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Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson’s disease by Maszlag-Török, Rita, Boros, Fanni A., Vécsei, László, Klivényi, Péter

“…Parkinson’s disease (PD) is a neurodegenerative disease caused by complex interaction between genetic and environmental factors. There is a growing body of…”
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Changing the face of kynurenines and neurotoxicity: therapeutic considerations by Bohár, Zsuzsanna, Toldi, József, Fülöp, Ferenc, Vécsei, László

“…Kynurenines are the products of tryptophan metabolism. Among them, kynurenine and kynurenic acid are generally thought to have neuroprotective properties,…”
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The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain by Martos, Diána, Lőrinczi, Bálint, Szatmári, István, Vécsei, László, Tanaka, Masaru

“…The central nervous system (CNS) is the final frontier in drug delivery because of the blood-brain barrier (BBB), which poses significant barriers to the…”
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Pharmacological aspects of the neuroprotective effects of irreversible MAO-B inhibitors, selegiline and rasagiline, in Parkinson’s disease by Szökő, Éva, Tábi, Tamás, Riederer, Peter, Vécsei, László, Magyar, Kálmán

“…The era of MAO-B inhibitors dates back more than 50 years. It began with Kálmán Magyar’s outstanding discovery of the selective inhibitor, selegiline. This…”
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Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis by Rajda, Cecilia, Pukoli, Dániel, Bende, Zsuzsanna, Majláth, Zsófia, Vécsei, László

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). There is increasing evidence that MS is not only characterized…”
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Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period by Tuka, Bernadett, Nyári, Aliz, Cseh, Edina Katalin, Körtési, Tamás, Veréb, Dániel, Tömösi, Ferenc, Kecskeméti, Gábor, Janáky, Tamás, Tajti, János, Vécsei, László

“…Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that…”
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Co-Players in Chronic Pain: Neuroinflammation and the Tryptophan-Kynurenine Metabolic Pathway by Tanaka, Masaru, Török, Nóra, Tóth, Fanni, Szabó, Ágnes, Vécsei, László

“…Chronic pain is an unpleasant sensory and emotional experience that persists or recurs more than three months and may extend beyond the expected time of…”
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Proteomics in Multiple Sclerosis: The Perspective of the Clinician by Sandi, Dániel, Kokas, Zsófia, Biernacki, Tamás, Bencsik, Krisztina, Klivényi, Péter, Vécsei, László

“…Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS) that affects approximately 2.8…”
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Neuroprotection in Parkinson’s disease: facts and hopes by Salamon, András, Zádori, Dénes, Szpisjak, László, Klivényi, Péter, Vécsei, László

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Behind the symptoms there is a complex pathological mechanism which…”
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Cerebrospinal fluid lipidomic biomarker signatures of demyelination for multiple sclerosis and Guillain–Barré syndrome by Péter, Mária, Török, Wanda, Petrovics-Balog, Anna, Vígh, László, Vécsei, László, Balogh, Gábor

“…Multiple sclerosis (MS) and Guillain – Barré syndrome (GBS) are demyelinating disorders affecting the central nervous system and peripheral nervous system…”
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Non-invasive Brain Stimulation in Alzheimer's Disease and Mild Cognitive Impairment-A State-of-the-Art Review on Methodological Characteristics and Stimulation Parameters by Holczer, Adrienn, Németh, Viola Luca, Vékony, Teodóra, Vécsei, László, Klivényi, Péter, Must, Anita

“…Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been proposed as a new therapeutic way to enhance the cognition…”
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Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System by Rajda, Cecilia, Majláth, Zsófia, Pukoli, Dániel, Vécsei, László

“…Multiple sclerosis is an inflammatory disease of the central nervous system, in which axonal transection takes place in parallel with acute inflammation to…”
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Cerebrospinal Fluid Neurofilament Light Chain Is Associated with Kynurenine Pathway Metabolite Changes in Multiple Sclerosis by Rajda, Cecilia, Galla, Zsolt, Polyák, Helga, Maróti, Zoltán, Babarczy, Kristóf, Pukoli, Dániel, Vécsei, László

“…Neurofilament light (NFL) has proved to be a good prognostic factor in multiple sclerosis (MS), as its level is proportionally elevated with extended…”
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Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid by Spekker, Eleonóra, Laborc, Klaudia Flóra, Bohár, Zsuzsanna, Nagy-Grócz, Gábor, Fejes-Szabó, Annamária, Szűcs, Mónika, Vécsei, László, Párdutz, Árpád

“…Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a…”
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Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression by Zádor, Ferenc, Joca, Sâmia, Nagy-Grócz, Gábor, Dvorácskó, Szabolcs, Szűcs, Edina, Tömböly, Csaba, Benyhe, Sándor, Vécsei, László

“…Substance use/abuse is one of the main causes of depressive symptoms. Cannabis and synthetic cannabinoids in particular gained significant popularity in the…”
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The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia by Szabo, Melinda, Lajkó, Noémi, Dulka, Karolina, Barczánfalvi, Gábor, Lőrinczi, Bálint, Szatmári, István, Mihály, András, Vécsei, László, Gulya, Karoly

“…We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-penetrable analog N…”
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