Search Results - "Vänttinen, Ida"

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia by Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

“…The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy…”
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Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine by Tambe, Mahesh, Unterberger, Sarah, Kriegbaum, Mette C., Vänttinen, Ida, Olgac, Ezgi June, Vähä-Koskela, Markus, Kontro, Mika, Wennerberg, Krister, Heckman, Caroline A.

“…Venetoclax plus azacitidine treatment is clinically beneficial for elderly and unfit acute myeloid leukemia (AML) patients. However, the treatment is rarely…”
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Ex Vivo Venetoclax Sensitivity Predicts Clinical Response in Acute Myeloid Leukemia in the Prospective VenEx Trial by Kytölä, Sari, Vänttinen, Ida Maria, Ruokoranta, Tanja, Partanen, Anu, Holopainen, Annasofia, Saad, Joseph, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka Katariina, Itälä-Remes, Maija, Västrik, Imre, Suvela, Minna, Parsons, Alun Owen, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Jalkanen, Tero, Huttunen, Teppo, Ettala, MD, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, Kuusanmäki, Heikki, Kontro, Mika

“…The BCL2 inhibitor venetoclax has shown promise for treating acute myeloid leukemia (AML). However, identifying patients likely to respond remains a challenge,…”
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P409: BCL‐2/BCL‐XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53‐MUTATED ACUTE MYELOID LEUKEMIA by Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein‐Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika

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P562: CAPILLARY BLOOD SAMPLING ALLOWS FEASIBLE METHOD FOR VENETOCLAX CONCENTRATION MEASUREMENT IN AN ACADEMIC MULTICENTER CLINICAL TRIAL CONTEXT by Kytölä, Sari, Vänttinen, Ida, Kuusanmäki, Heikki, Ruokoranta, Tanja, Kurkela, Mika, Kiiski, Johanna, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä‐Remes, Maija, Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, T. Backman, Janne, Niemi, Mikko, Kontro, Mika

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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia by Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu

“…•High-throughput screening of >500 drugs identifies BCL-XL inhibitor sensitivity and venetoclax resistance in erythroid/megakaryocytic AML.•BCL2L1 (BCL-XL) is…”
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Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window by Satomaa, Tero, Pynnönen, Henna, Aitio, Olli, Hiltunen, Jukka O, Pitkänen, Virve, Lähteenmäki, Tuula, Kotiranta, Titta, Heiskanen, Annamari, Hänninen, Anna-Liisa, Niemelä, Ritva, Helin, Jari, Kuusanmäki, Heikki, Vänttinen, Ida, Rathod, Ramji, Nieminen, Anni I, Yatkin, Emrah, Heckman, Caroline A, Kontro, Mika, Saarinen, Juhani

“…CD33 (Siglec-3) is a cell surface receptor expressed in approximately 90% of acute myeloid leukemia (AML) blasts, making it an attractive target for therapy of…”
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Targeting Venetoclax Resistance in TP53-Mutated Acute Myeloid Leukemia by Vänttinen, Ida, Ruokoranta, Tanja, Saad, Joseph J, Kytölä, Sari, Hellesøy, Monica, Gullaksen, Stein-Erik, Ettala, Pia-Sofia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Wennerberg, Krister, Gjertsen, Bjorn T., Heckman, Caroline A., Kontro, Mika, Kuusanmäki, Heikki

“…Introduction: The combination therapy of Venetoclax (Ven) and Azacitidine (Aza) has shown remarkable improvements in the treatment of acute myeloid leukemia…”
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Ex Vivo Drug Sensitivity Testing to Predict Response to Venetoclax + Azacitidine in Acute Myeloid Leukemia: Interim Results of the Prospective Multicenter Phase II Venex Trial by Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ranta, Amanda, Ruokoranta, Tanja, Holopainen, Annasofia, Koskela, Sirpa, Kuusisto, Milla E.L., Porkka, Kimmo, Räty, Riikka, Västrik, Imre, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

“…Background BCL-2 inhibitor venetoclax (Ven) in combination with azacitidine (Aza) has substantially improved overall response rates (ORR) and overall survival…”
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Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax by Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Ranta, Amanda, Suvela, Minna, Parsons, Alun, Västrik, Imre, Siitonen, Sanna M., Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, Kuusanmäki, Heikki, Kontro, Mika

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Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia by Dufva, Olli, Kuusanmäki, Heikki, Vaha-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra Johanna, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Awad, Shady Adnan, Mancebo, Cristina, Saad, Joseph, Miettinen, Juho J., Javarappa, Komal Kumar, Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Wartiovaara-Kautto, Ulla, Konopleva, Marina, Keränen, Mikko A, Porkka, Kimmo, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu

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