Search Results - "Väänänen, H.K."

Role of insulin and hyperglycemia in the modulation of osteocalcin secretion in osteoblasts by Ivaska, K.K, Virta, A.-R, Halme, L, Heino, T, Väänänen, H.K

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Conditionally immortalized bone marrow progenitor cell lines as models for osteogenic and adipogenic differentiation by Ivaska, K.K, Jiang, M, Silvola, T, Buki, K, Härkönen, P, Väänänen, H.K

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Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading by Imai, S, Heino, T.J, Hienola, A, Kurata, K, Büki, K, Matsusue, Y, Väänänen, H.K, Rauvala, H

“…Abstract HB-GAM (also known as pleiotrophin) is a cell matrix-associated protein that is highly expressed in bone. It affects osteoblast function, and might…”
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Markers of bone turnover in peripubertal girls by Fagerlund, K.M, Lehtonen-Veromaa, M, Möttönen, T, Leino, A, Viikari, J, Väänänen, H.K, Halleen, J.M

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The mechanical strength of bone in different rat models of experimental osteoporosis by Peng, Z, Tuukkanen, J, Zhang, H, Jämsä, T, Väänänen, H K

“…In order to discover good parameters for experimental osteoporosis, we measured the failure load of the femoral neck and the bending strength of the tibia in…”
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β1 integrins and osteoclast function : Involvement in collagen recognition and bone resorption by HELFRICH, M. H, NESBITT, S. A, LAKKAKORPI, P. T, BARNES, M. J, BODARY, S. C, SHANKAR, G, MASON, W. T, MENDRICK, D. L, VÄÄNÄNEN, H. K, HORTON, M. A

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Long-term effects of ovariectomy on the mechanical properties and chemical composition of rat bone by Peng, Z.-Q., Väänänen, H.K., Zhang, H.X., Tuukkanen, J.

“…One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed…”
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Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes by Kähkönen, T.E., Ivaska, K.K., Jiang, M., Büki, K.G., Väänänen, H.K., Härkönen, P.L.

“…Fibroblast growth factors (FGF) and their receptors (FGFRs) regulate many developmental processes including differentiation of mesenchymal stromal cells (MSC)…”
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Long-term effects of clodronate on growing rat bone by Lepola, V.T., Hannuniemi, R., Kippo, K., Laurén, L., Jalovaara, P., Väänänen, H.K.

“…For evaluating the long-term effects of the bisphosphonate compound clodronate on the rat skeleton, 100 female rats were given subcutaneous injections of…”
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The Regulation of pHiin Osteoclasts Is Dependent on the Culture Substrate and on the Stage of the Resorption Cycle by Lehenkari, P.P., Laitala-Leinonen, T., Linna, T.-J., Väänänen, H.K.

“…The present study was performed to clarify the role of vacuolar H+-ATPase in the regulation of the intracellular pH (pHi) in osteoclasts. Bafilomycin A1or…”
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Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density by Halleen, J M, Ylipahkala, H, Alatalo, S L, Janckila, A J, Heikkinen, J E, Suominen, H, Cheng, S, Väänänen, H K

“…Human serum contains two isoforms of tartrate-resistant acid phosphatase (TRACP) known as TRACP 5a and TRACP 5b with pH optima of 5.0 and 5.8, respectively…”
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Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture by Qu, Q., Perälä-Heape, M., Kapanen, A., Dahllund, J., Salo, J., Väänänen, H.K., Härkönen, P.

“…The effects of estrogen on bone are possibly mediated by several cell types. In the present study, the effect of 17β-estradiol (E 2) on osteoblast-like cells…”
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Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia by Jämsä, T, Jalovaara, P, Peng, Z, Väänänen, H.K, Tuukkanen, J

“…We compared the mechanical and densitometric testing methods in evaluating the mechanical strength of mouse cortical bones. The femora and tibiae of 10 male…”
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Development of a novel three-dimensional culture system to study the role of mechanically damaged osteocytes in the initiation of targeted bone remodeling by Heino, T.J., Kurata, K., Higaki, H., Väänänen, H.K.

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Conditioned medium of Estrogen-treated osteoblasts inhibits osteoclast maturation and function in vitro by Qu, Q, Härkönen, P.L, Mönkkönen, J, Väänänen, H.K

“…The increase of bone resorption and reduction of bone mass in postmenopausal women can be prevented by treatment with estrogen. Although it is well established…”
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The use of myoglobin/carbonic anhydrase III ratio as a marker for myocardial damage in patients with renal failure by Vuori, J., Huttunen, K., Vuotikka, P., Väänänen, H.K.

“…To evaluate the clinical significance of myoglobin and myoglobin/CA III ratio as a biochemical marker for acute myocardial infarction (AMI) in patients with…”
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Effect of clodronate treatment on established bone loss in ovariectomized rats by Kippo, K, Hannuniemi, R, Laurén, L, Peng, Z, Kuurtamo, P, Virtamo, T, Isaksson, P, Österman, T, Väänänen, H.K, Sellman, R

“…The ability of clodronate to prevent bone loss and weakening of bone strength was studied in adult rats with established osteopenia. Six-month-old female…”
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Intracellular degradation of osteoclast bone resorption products by hydroxyl radicals generated by tartrate-resistant acid phosphatase by Halleen, J.M., Räisänen, S., Salo, J.J., Hentunen, T.A., Lehenkari, P.P., Väänänen, H.K.

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β 1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption by Helfrich, M.H., Nesbitt, S.A., Lakkakorpi, P.T., Barnes, M.J., Bodary, S.C., Shankar, G., Mason, W.T., Mendrick, D.L., Väänänen, H.K., Horton, M.A.

“…The extracellular matrix of bone is composed mainly of type I collagen. In this report we studied the role and collagen binding properties of osteoclast…”
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Carbonic anhydrase isoenzymes in isolated rat peripheral monocytes, tissue macrophages, and osteoclasts by Sundquist, K T, Leppilampi, M, Järvelin, K, Kumpulainen, T, Väänänen, H K

“…The presence of carbonic anhydrase isoenzymes I and II in rat monocytes and macrophagelike cells was studied using monospecific antisera against rat carbonic…”
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