Search Results - "Väänänen, H. Kalervo"

The critical role of IL-34 in osteoclastogenesis by Chen, Zhi, Buki, Kalman, Vääräniemi, Jukka, Gu, Guoliang, Väänänen, H Kalervo

“…It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also known as CSF-1) and RANKL. Recently, a novel cytokine,…”
Get full text

Osteoclast lineage and function by Väänänen, H. Kalervo, Laitala-Leinonen, Tiina

“…Osteoclasts are members of the monocyte/macrophage lineage and are formed by cellular fusions from their mononuclear precursors. Their differentiation is…”
Get full text

Mesenchymal stem cells by Väänänen, H Kalervo

“…About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to…”
Get more information

Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women by Lu, Chunyan, Ivaska, Kaisa K, Alen, Markku, Wang, Qingju, Törmäkangas, Timo, Xu, Leiting, Wiklund, Petri, Mikkola, Tuija M, Pekkala, Satu, Tian, Haoming, Väänänen, H. Kalervo, Cheng, Sulin

“…Context: The skeleton is recognized as an important player in energy metabolism through its interactions with other tissues. Whether the association of…”
Get full text

Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption by Michael, Husheem, Härkönen, Pirkko L, Väänänen, H Kalervo, Hentunen, Teuvo A

“…Using human peripheral blood CD14+ osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological…”
Get full text

Associations Between Homocysteine, Bone Turnover, BMD, Mortality, and Fracture Risk in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Obrant, Karl J, Åkesson, Kristina

“…Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from the OPRA study, high homocysteine…”
Get full text

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial by Cheng, Sulin, Lyytikäinen, Arja, Kröger, Heikki, Lamberg-Allardt, Christel, Alén, Markku, Koistinen, Arvo, Wang, Qing Ju, Suuriniemi, Miia, Suominen, Harri, Mahonen, Anitta, Nicholson, Patrick HF, Ivaska, Kaisa K, Korpela, Riitta, Ohlsson, Claes, Väänänen, Kalervo H, Tylavsky, Frances

“…BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone…”
Get full text

Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1 by Riihonen, Riikka, Nielsen, Søren, Väänänen, H. Kalervo, Laitala-Leinonen, Tiina, Kwon, Tae-Hwan

“…Dissolution of the inorganic bone matrix releases not only calcium and phosphate ions, but also bicarbonate. Electroneutral sodium-bicarbonate co-transporter…”
Get full text

Regulation of Osteoblast Differentiation: A Novel Function for Fibroblast Growth Factor 8 by Valta, Maija P, Hentunen, Teuvo, Qu, Qiang, Valve, Eeva M, Harjula, Anna, Seppänen, Jani A, Väänänen, H. Kalervo, Härkönen, Pirkko L

“…Several members of the fibroblast growth factor (FGF) family have an important role in the development of skeletal tissues. FGF-8 is widely expressed in the…”
Get full text

Biochemical Markers of Bone Metabolism and Prediction of Fracture in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Alatalo, Sari L, Halleen, Jussi M, Hellman, Jukka, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Åkesson, Kristina, Obrant, Karl J

“…We studied the ability of various markers of bone turnover to predict fracture in 1040 randomly recruited 75‐year‐old women. A total of 178 of the women…”
Get full text

Serial Assessment of Serum Bone Metabolism Markers Identifies Women with the Highest Rate of Bone Loss and Osteoporosis Risk by Ivaska, Kaisa K., Lenora, Janaka, Gerdhem, Paul, Åkesson, Kristina, Väänänen, H. Kalervo, Obrant, Karl J.

“…Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility…”
Get full text

Release of Intact and Fragmented Osteocalcin Molecules from Bone Matrix during Bone Resorption in Vitro by Ivaska, Kaisa K, Hentunen, Teuvo A, Vääräniemi, Jukka, Ylipahkala, Hannele, Pettersson, Kim, Väänänen, H Kalervo

“…Osteocalcin detected from serum samples is considered a specific marker of osteoblast activity and bone formation rate. However, osteocalcin embedded in bone…”
Get full text

Bone Marrow Cell Differentiation Induced by Mechanically Damaged Osteocytes in 3D Gel‐Embedded Culture by Kurata, Kosaku, Heino, Terhi J, Higaki, Hidehiko, Väänänen, H Kalervo

“…Osteocytes are suggested to have a crucial role in the initial resorptive phase of bone turnover after microdamage. To study the role of osteocytes in targeted…”
Get full text

The effects of acute hyperinsulinemia on bone metabolism by K Ivaska, Kaisa, K Heliövaara, Maikki, Ebeling, Pertti, Bucci, Marco, Huovinen, Ville, Kalervo Väänänen, H, Nuutila, Pirjo, A Koistinen, Heikki

“…Insulin signaling in bone-forming osteoblasts stimulates bone formation and promotes the release of osteocalcin (OC) in mice. Only a few studies have assessed…”
Get full text

Membrane-bound carbonic anhydrases in osteoclasts by Riihonen, Riikka, Supuran, Claudiu T, Parkkila, Seppo, Pastorekova, Silvia, Väänänen, H. Kalervo, Laitala-Leinonen, Tiina

“…Abstract Osteoclasts are multinucleated bone-resorbing cells that use multiple pH regulation mechanisms to create an acidic pH in the resorption lacuna…”
Get full text

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite by Lehenkari, Petri P, Kellinsalmi, Maarit, Näpänkangas, Juha P, Ylitalo, Kari V, Mönkkönen, Jukka, Rogers, Michael J, Azhayev, Alex, Väänänen, H Kalervo, Hassinen, Ilmo E

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. Recent studies…”
Get more information

Estrogen and the selective estrogen receptor modulator (SERM) protection against cell death in estrogen receptor alpha and beta expressing U2OS cells by Kallio, Anu, Guo, Tao, Lamminen, Elisa, Seppänen, Jani, Kangas, Lauri, Väänänen, H. Kalervo, Härkönen, Pirkko

“…In the current work, we compared the ability of 17β-estradiol (E 2) and the selective estrogen receptor modulators (SERMs), tamoxifen (Tam), raloxifene (Ral)…”
Get full text

Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors by Tuomela, Johanna, Valta, Maija, Seppänen, Jani, Tarkkonen, Kati, Väänänen, H Kalervo, Härkönen, Pirkko

“…Prostate cancer metastasizes to regional lymph nodes and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully…”
Get full text

Urinary Osteocalcin as a Marker of Bone Metabolism by Ivaska, Kaisa K, Kakonen, Sanna-Maria, Gerdhem, Paul, Obrant, Karl J, Pettersson, Kim, Vaananen, H. Kalervo

“…Osteocalcin (OC) is produced by osteoblasts during bone formation, and circulating OC has been used in clinical investigations as a marker of bone metabolism…”
Get full text

A Rationale for Osteoclast Selectivity of Inhibiting the Lysosomal V-ATPase a3 Isoform by Nyman, Jonas K. E., Väänänen, H. Kalervo

“…Osteoclastic bone resorption can be completely abolished by inhibiting the vacuolar H + -ATPase (V-ATPase), a proton pump composed of at least 12 different…”
Get full text