Antioxidants restore aortic ring relaxation in pancreatectomized rats

Vascular response was assessed in rats made diabetic by subtotal pancreatectomy (PPx). Adult male Wistar rats submitted to PPx eight weeks earlier, and exhibiting altered levels of fasting glucose and an abnormal tolerance glucose test, were used. Sham-operated laparotomized rats were employed as co...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 81; no. 19; pp. 1467 - 1472
Main Authors:	Reyes-Toso, Carlos F., Linares, Laura M., Witriw, Alicia, Vázquez, Marisa B., Ricci, Conrado R., Cardinali, Daniel P.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 27-10-2007
Subjects:	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology Acetylcholine - pharmacology Animals Antioxidants Antioxidants - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Aortic relaxation Dose-Response Relationship, Drug Endothelium, Vascular - physiology Glucose - pharmacology In Vitro Techniques Melatonin - pharmacology Nitroprusside - pharmacology Pancreatectomized rats Pancreatectomy Phenylephrine - pharmacology Rats Rats, Wistar Superoxide Dismutase - pharmacology Thiobarbituric Acid Reactive Substances - metabolism Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology Antioxidants Pancreatectomized rats Aortic relaxation
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Summary:	Vascular response was assessed in rats made diabetic by subtotal pancreatectomy (PPx). Adult male Wistar rats submitted to PPx eight weeks earlier, and exhibiting altered levels of fasting glucose and an abnormal tolerance glucose test, were used. Sham-operated laparotomized rats were employed as controls. Dose–response curves for acetylcholine-induced, endothelium-related relaxation of aortic rings (after previous exposure to phenylephrine) were conducted in a high glucose solution (44 mmol/L). PPx decreased significantly acetylcholine-induced relaxation only in the presence of a high glucose solution ( p < 0.00001). Tiron, superoxide dismutase (SOD) or melatonin restored altered aortic relaxation. Melatonin, SOD or Tiron were equally effective in restoring the impaired sodium nitroprusside-induced vasorelaxation in endothelium-denuded aortic rings of PPx rats. The results support the evidence about the ability of antioxidants to restore altered vascular reactivity of aortic rings in PPx rats, probably through the scavenging property of superoxide anion accumulation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2007.09.015