Search Results - "Vágó, István"

Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560) by Ledneczki, István, Némethy, Zsolt, Molnár, Katalin Dudásné, Tapolcsányi, Pál, Ilkei, Viktor, Vágó, István, Kolok, Sándor, Thán, Márta, Laszy, Judit, Balázs, Ottilia, Krámos, Balázs, Szigetvári, Áron, Bata, Imre, Makó, Attila, Visegrády, András, Fodor, László, Vastag, Mónika, Lévay, György, Lendvai, Balázs, Greiner, István, Éles, János

“…During optimization of a previously identified lead compound, attempts were made to optimize the reactive indole structural element, the suboptimal metabolic…”
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Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists by Éles, János, Beke, Gyula, Vágó, István, Bozó, Éva, Huszár, József, Tarcsay, Ákos, Kolok, Sándor, Schmidt, Éva, Vastag, Mónika, Hornok, Katalin, Farkas, Sándor, Domány, György, Keserű, György M.

“…A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were…”
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HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor by Ledneczki, István, Horváth, Anita, Tapolcsányi, Pál, Éles, János, Molnár, Katalin Dudás, Vágó, István, Visegrády, András, Kiss, László, Szigetvári, Áron, Kóti, János, Krámos, Balázs, Mahó, Sándor, Holm, Patrik, Kolok, Sándor, Fodor, László, Thán, Márta, Kostyalik, Diána, Balázs, Ottilia, Vastag, Mónika, Greiner, István, Lévay, György, Lendvai, Balázs, Némethy, Zsolt

“…HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During…”
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Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors by Ágai-Csongor, Éva, Domány, György, Nógrádi, Katalin, Galambos, János, Vágó, István, Keserű, György Miklós, Greiner, István, Laszlovszky, István, Gere, Anikó, Schmidt, Éva, Kiss, Béla, Vastag, Mónika, Tihanyi, Károly, Sághy, Katalin, Laszy, Judit, Gyertyán, István, Zájer-Balázs, Mária, Gémesi, Larisza, Kapás, Margit, Szombathelyi, Zsolt

“…Cariprazine, a potential atypical antipsychotic agent has been identified during the optimization of novel series of 4-aryl-piperazine derivatives. The…”
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Relative Stability and Structure of Dihydro-1,2,4-triazines:  A Theoretical Study by Nagy, József, Nyitrai, József, Vágó, István, Csonka, Gábor I

“…A brief survey is given on the synthesis and structure elucidation for dihydro-1,2,4-triazines. The relative stability of nine possible dihydro-1,2,4-triazines…”
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New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones by Szántó, Gábor, Makó, Attila, Vágó, István, Hergert, Tamás, Bata, Imre, Farkas, Bence, Kolok, Sándor, Vastag, Mónika

“…[Display omitted] Numerous potent P2X3 antagonists have been discovered and the therapeutic potential of P2X3 antagonism already comprises proof-of-concept…”
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A useful acylation method using trichloroacetonitrile and triphenylphosphine for solid phase organic synthesis by Vágó, István, Greiner, István

“…A novel acylation procedure was developed for polymer supported synthesis, with in situ generated acyl chlorides using trichloroacetonitrile and…”
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Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile by Ágai-Csongor, Éva, Nógrádi, Katalin, Galambos, János, Vágó, István, Bielik, Attila, Magdó, Ildikó, Ignácz-Szendrei, Györgyi, Keserű, György Miklós, Greiner, István, Laszlovszky, István, Béla Kiss, Éva Schmidt, Judit Laszy, Katalin Sághy, Gyertyán, István, Zájer-Balázs, Mária, Gémesi, Larisza, Domány, György

“…Novel arylsulfonamides were identified as high-affinity dopamine D3 and D2 receptor ligands. Some derivatives were found to be active in antipsychotic tests in…”
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Construction of a Linux based chemical and biological information system by Molnár, László, Vágó, István, Fehér, András

“…A chemical and biological information system with a Web-based easy-to-use interface and corresponding databases has been developed. The constructed system…”
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Synthesis of Vinca Alkaloids and Related Compounds 95. Attempted Build-up of the Aspidospermidine Skelton by [4+2] Cycloaddition. Some Unexpected Reactions, and Formation of a New Ring System by Szántay, Csaba, Vágó, István, Kalaus, György, Greiner, István, Kajtár-Peredy, Mária, Brlik, János, Szabó, Lajos

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