Search Results - "Uzonyi, Anna"
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Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution
Published in Nature methods (01-09-2021)“…N 6 -methyladenosine (m6A) is the most prevalent modification of messenger RNA in mammals. To interrogate its functions and dynamics, there is a critical need…”
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Dissecting the sequence and structural determinants guiding m6A deposition and evolution via inter- and intra-species hybrids
Published in Genome Biology (15-02-2024)“…N6-methyladenosine (m6A) is the most abundant mRNA modification, and controls mRNA stability. m6A distribution varies considerably between and within species…”
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Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2
Published in Nature communications (11-12-2023)“…Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants…”
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Cloning of DNA oligo pools for in vitro expression
Published in STAR protocols (18-03-2022)“…Oligo library pools are powerful tools for systematic investigation of genetic and transcriptomic machinery such as promoter function and gene regulation,…”
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A single-embryo, single-cell time-resolved model for mouse gastrulation
Published in Cell (27-05-2021)“…Mouse embryonic development is a canonical model system for studying mammalian cell fate acquisition. Recently, single-cell atlases comprehensively charted…”
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Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Published in Molecular cell (19-01-2023)“…N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-uniformly distributed across the transcriptome, yet the basis for its selective…”
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Deciphering the principles of the RNA editing code via large-scale systematic probing
Published in Molecular cell (03-06-2021)“…Adenosine-to-inosine editing is catalyzed by ADAR1 at thousands of sites transcriptome-wide. Despite intense interest in ADAR1 from physiological,…”
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Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation
Published in Molecular and cellular biology (01-09-2018)“…Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed…”
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AI in search of human help
Published in Science (American Association for the Advancement of Science) (14-07-2023)Get full text
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Research beneficiaries speak
Published in Science (American Association for the Advancement of Science) (05-04-2024)Get full text
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A pandemic education
Published in Science (American Association for the Advancement of Science) (11-03-2022)Get full text
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Back in person, back to the races
Published in Science (American Association for the Advancement of Science) (07-01-2022)Get full text
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News from a postpandemic world
Published in Science (American Association for the Advancement of Science) (03-07-2020)Get full text
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