Search Results - "Uzairu, Adamu"

Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl- and 2-acylloxyethylsulfonamides as potent anti-fungal agents by Isyaku, Yusuf, Uzairu, Adamu, Uba, Sani

“…Botrytis Cinerea is a plant pathogen that affect a large number of plant species like tomatoes, Lettuce, Grapes, and Strawberries among others. Sulfonamides…”
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Virtual screening, pharmacokinetic, and DFT studies of anticancer compounds as potential V600E-BRAF kinase inhibitors by Umar, Abdullahi B, Uzairu, Adamu

“…kinase is an essential therapeutic target in melanoma and other types of tumors. Because of its resistance to known inhibitors and the adverse effects of some…”
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QSAR modeling, molecular docking and ADMET/pharmacokinetic studies: a chemometrics approach to search for novel inhibitors of norepinephrine transporter as potent antipsychotic drugs by Olasupo, Sabitu Babatunde, Uzairu, Adamu, Shallangwa, Gideon, Uba, Sani

“…Chemometrics study that relates biological activity to physicochemical descriptors of a molecule and the prediction of absorption, distribution, metabolism,…”
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Modelling PIP4K2A inhibitory activity of 1,7-naphthyridine analogues using machine learning and molecular docking studies by Ibrahim, Muktar Musa, Uzairu, Adamu, Ibrahim, Muhammad Tukur, Umar, Abdullahi Bello

“…PIP4K2A is a type II lipid kinase that catalyzed the rate-limiting step of the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol…”
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QSAR, molecular docking, design, and pharmacokinetic analysis of 2-(4-fluorophenyl) imidazol-5-ones as anti-breast cancer drug compounds against MCF-7 cell line by Lawal, Hadiza Abdulrahman, Uzairu, Adamu, Uba, Sani

“…The anti-proliferative activities of Novel series of 2-(4-fluorophenyl) imidazol-5-ones against MCF-7 breast cancer cell line were explored via in-slico…”
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Molecular docking study and structure‐based design of novel camptothecin analogues used as topoisomerase I inhibitor by Arthur, David Ebuka, Uzairu, Adamu

“…The paper describes the molecular docking study of the inhibition of human topoisomerase I (Top1), which is the molecular target of a diverse set of anticancer…”
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Development and Validation of Predictive Quantitative Structure–Activity Relationship Models for Estrogenic Activities of Hydroxylated Polychlorinated Biphenyls by Akinola, Lukman K., Uzairu, Adamu, Shallangwa, Gideon A., Abechi, Stephen E.

“…Disruption of the endocrine system by hydroxylated polychlorinated biphenyls (OH‐PCBs) is hypothesized, among other potential mechanisms, to be mediated via…”
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Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium by Ameji, Philip John, Uzairu, Adamu, Shallangwa, Gideon Adamu, Uba, Sani

“…In pursuit of novel antibiotics that could curb the growing trend of multidrug resistance by Salmonella typhimurium, a data set of some cephalosporin analogues…”
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Quantitative structure–activity relationship modeling of hydroxylated polychlorinated biphenyls as constitutive androstane receptor agonists by Akinola, Lukman Kehinde, Uzairu, Adamu, Shallangwa, Gideon Adamu, Abechi, Stephen Eyije

“…Hydroxylated polychlorinated biphenyls (OH-PCBs), a series of toxic chemical compounds produced via biotic and abiotic transformation of polychlorinated…”
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Computer modeling of some anti-breast cancer compounds by Abdulrahman, Hadiza Lawal, Uzairu, Adamu, Uba, Sani

“…The research was aimed at exploring the biological activities of novel series of β-lactam derivatives against MCF-7 breast cancer cell lines via computer…”
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Computational modeling and molecular dynamics studies of methyl sulfonyl acetate derivatives as potent SmTGR inhibitors: insights into binding interactions by Ja'afaru, Saudatu Chinade, Uzairu, Adamu, Mishra, Vipin Kumar, Sallau, Muhammed Sani, Ibrahim, Muhammad Tukur, Dubey, Amit

“…Schistosomiasis, a neglected tropical disease caused by flatworms of the Schistosoma genus, can lead to severe health complications such as Hepatosplenomegaly,…”
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Ligand-based design of chalcone analogues and thermodynamic analysis of their mechanism of free radical scavenge by Alisi, Ikechukwu Ogadimma, Uzairu, Adamu, Idris, Sulaiman Ola

“…Overproduction of free radicals in the body may result in oxidative stress, which plays an active role in the development of various health disorders…”
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In-silico studies of some oxadiazoles derivatives as anti-diabetic compounds by Ibrahim, Muhammad Tukur, Uzairu, Adamu, Shallangwa, Gideon Adamu, Ibrahim, Abdulqadir

“…An in-silico study was performed to investigate the anti-diabetic activities of 27 Oxadiazoles derivatives. The anti-diabetic compounds were optimized using…”
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New flavone-based arylamides as potential V600E-BRAF inhibitors: Molecular docking, DFT, and pharmacokinetic properties by Umar, Abdullahi B., Uzairu, Adamu

“…يعتبر بروتين كيناز "ب.ر.أ.ف.في-600إي" هدفا علاجيا جذابا وأساسيا في علاج سرطان الجلد وأنواع أخرى من الأورام. ومع ذلك، فإن مقاومته للمثبطات والآثار الجانبية…”
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In silico QSAR and molecular docking simulation of some novel aryl sulfonamide derivatives as inhibitors of H5N1 influenza A virus subtype by Abdullahi, Mustapha, Shallangwa, Gideon Adamu, Uzairu, Adamu

“…Background This research provides a comprehensive analysis of QSAR modeling performed on 25 aryl sulfonamide derivatives to predict their effective…”
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Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation by Akinola, Lukman K., Uzairu, Adamu, Shallangwa, Gideon A., Abechi, Stephen E.

“…Polychlorinated dibenzo‐p‐dioxins (PCDDs) are hypothesized to exert their toxic effects in wildlife and humans via endocrine disruption. However, very scanty…”
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Theoretical modeling for predicting the activities of some active compounds as potent inhibitors against Mycobacterium tuberculosis using GFA-MLR approach by Adeniji, Shola Elijah, Uba, Sani, Uzairu, Adamu

“…Tuberculosis (TB) is of one the most infectious disease caused by Mycobacterium tuberculosis which remains a serious public health problem. Emergence of…”
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Free radical scavenging mechanism of 1,3,4-oxadiazole derivatives: thermodynamics of O–H and N–H bond cleavage by Alisi, Ikechukwu Ogadimma, Uzairu, Adamu, Abechi, Stephen Eyije

“…The thermodynamics of free radical scavenge of 1,3,4-oxadiazole derivatives towards oxygen-centred free radicals were investigated by the density functional…”
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Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1,4,5-trisubstituted 1,2,3-triazoles derivatives as elevators of p53 protein levels by Ya'u Ibrahim, Zakari, Uzairu, Adamu, Shallangwa, Gideon, Abechi, Stephen

“…Malaria is a killer disease caused by Plasmodium falciparum and is responsible for over a million death annually. Chloroquine, quinine, pyrimethamine,…”
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Unveiling potent inhibitors for schistosomiasis through ligand-based drug design, molecular docking, molecular dynamics simulations and pharmacokinetics predictions by Ja'afaru, Saudatu Chinade, Uzairu, Adamu, Bayil, Imren, Sallau, Muhammed Sani, Ndukwe, George Iloegbulam, Ibrahim, Muhammad Tukur, Moin, Abu Tayab, Mollah, A K M Moniruzzaman, Absar, Nurul

“…Schistosomiasis is a neglected tropical disease which imposes a considerable and enduring impact on affected regions, leading to persistent morbidity,…”
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