Search Results - "Uwe Borgmeyer"

The adaptor protein PICK1 targets the sorting receptor SorLA by Binkle, Lars, Klein, Marcel, Borgmeyer, Uwe, Kuhl, Dietmar, Hermey, Guido

“…SorLA is a member of the Vps10p-domain (Vps10p-D) receptor family of type-I transmembrane proteins conveying neuronal endosomal sorting. The…”
Get full text

Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration by Cabron, Anne-Sophie, Borgmeyer, Uwe, Richter, Julia, Peisker, Helga, Gutbrod, Katharina, Dörmann, Peter, Capell, Anja, Damme, Markus

“…Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifier of disease risk in patients with…”
Get full text

Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis by Winschel, Ingo, Willing, Anne, Engler, Jan Broder, Walkenhorst, Mark, Meurs, Nina, Binkle-Ladisch, Lars, Woo, Marcel S, Pfeffer, Lena Kristina, Sonner, Jana K, Borgmeyer, Uwe, Hagen, Sven Hendrik, Grünhagel, Benjamin, Claussen, Janna M, Altfeld, Marcus, Friese, Manuel A

“…Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that predominantly affect women,…”
Get full text

Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1 by Sotoud, Hannieh, Borgmeyer, Uwe, Schulze, Christian, El-Armouche, Ali, Eschenhagen, Thomas

“…Phosphatase inhibitor-1 (I-1) inhibits the catalytic subunit of protein phosphatase type 1 (PP1c) in its protein kinase A (PKA)-phosphorylated form (I-1 P )…”
Get full text

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse by Schwerd, Tobias, Krause, Freia, Twigg, Stephen R F, Aschenbrenner, Dominik, Chen, Yin-Huai, Borgmeyer, Uwe, Müller, Miryam, Manrique, Santiago, Schumacher, Neele, Wall, Steven A, Jung, Jonathan, Damm, Timo, Glüer, Claus-Christian, Scheller, Jürgen, Rose-John, Stefan, Jones, E Yvonne, Laurence, Arian, Wilkie, Andrew O M, Schmidt-Arras, Dirk, Uhlig, Holm H

“…The GP130 cytokine receptor subunit encoded by is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in…”
Get full text

Germ Cell Nuclear Factor Is a Repressor of CRIPTO-1 and CRIPTO-3 by Hentschke, Moritz, Kurth, Ingo, Borgmeyer, Uwe, Hübner, Christian A.

“…The pluripotency of embryonic stem and embryonic carcinoma cells is maintained by the expression of a set of “stemness” genes. Whereas these genes are…”
Get full text

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR by Mangelsdorf, D J, Umesono, K, Kliewer, S A, Borgmeyer, U, Ong, E S, Evans, R M

“…The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR)…”
Get more information

Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development by Bettler, B, Boulter, J, Hermans-Borgmeyer, I, O'Shea-Greenfield, A, Deneris, E S, Moll, C, Borgmeyer, U, Hollmann, M, Heinemann, S

“…We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits…”
Get more information

Revisiting the proteolytic processing of cell adhesion molecule L1 by Kleene, Ralf, Lutz, David, Loers, Gabriele, Bork, Ute, Borgmeyer, Uwe, Hermans‐Borgmeyer, Irm, Schachner, Melitta

“…The important functions of cell adhesion molecule L1 in the nervous system depend on diverse proteolytic enzymes which generate different L1 fragments. It has…”
Get full text

A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function by Stürner, Klarissa Hanja, Borgmeyer, Uwe, Schulze, Christian, Pless, Ole, Martin, Roland

“…Multiple sclerosis (MS) is an autoimmune disease of the CNS, and autoreactive CD4(+) T cells are considered important for its pathogenesis. The etiology of MS…”
Get full text

The germ cell nuclear factor mGCNF is expressed in the developing nervous system by Süsens, U, Aguiluz, J B, Evans, R M, Borgmeyer, U

“…Using a reinoic acid receptor hybridization probe, we have isolated a mouse embryonic cDNA that encodes the germ cell nuclear factor (mGCNF). The in vitro…”
Get more information

Viral myb oncogene encodes a sequence-specific DNA-binding activity by Biedenkapp, Horst, Borgmeyer, Uwe, Sippel, Albrecht E, Klempnauer, Karl-Heinz

Get full text

The murine AE4 promoter predominantly drives type B intercalated cell specific transcription by Hentschke, Moritz, Hentschke, Suna, Borgmeyer, Uwe, Hübner, Christian Andreas, Kurth, Ingo

“…AE4 is an anion exchanger almost exclusively expressed in the collecting ducts of the kidney. This very restricted expression prompted us to analyze its…”
Get full text

Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion by Elmallah, Mohammed IY, Borgmeyer, Uwe, Betzel, Christian, Redecke, Lars

“…Prion diseases comprise a group of fatal neurodegenerative disorders characterized by the autocatalytic conversion of the cellular prion protein PrP C into the…”
Get full text

PGC-1 and PERC, coactivators of the estrogen receptor-related receptor γ by Hentschke, Moritz, Süsens, Ute, Borgmeyer, Uwe

“…The mouse nuclear receptor ERRγ (estrogen receptor-related receptor γ) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the…”
Get full text

Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma by Hentschke, Moritz, Borgmeyer, Uwe

“…Estrogen-related receptor gamma (ERRgamma) is an orphan nuclear receptor highly expressed in heart, skeletal muscle, kidney, and brain. To identify activation…”
Get full text

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse by Tobias Schwerd, Freia Krause, Stephen R.F.Twigg, Dominik Aschenbrenner, Yin-Huai Chen, Uwe Borgmeyer, Miryam Müller, Santiago Manrique, Neele Schumacher, Steven A.Wall, Jonathan Jung, Timo Damm, Claus-Christian Glüer, Jürgen Scheller, Stefan Rose-John, E.Yvonne Jones, Arian Laurence, Andrew O.M.Wilkie, Dirk Schmidt-Arras, Holm H.Uhlig

Get full text

Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRγ by Hentschke, Moritz, Borgmeyer, Uwe

“…Estrogen-related receptor γ (ERRγ) is an orphan nuclear receptor highly expressed in heart, skeletal muscle, kidney, and brain. To identify activation…”
Get full text

The forkhead transcription factor Foxi1 directly activates the AE4 promoter by Kurth, Ingo, Hentschke, Moritz, Hentschke, Suna, Borgmeyer, Uwe, Gal, Andreas, Hübner, Christian A

“…Intercalated cells are highly specialized cells within the renal collecting duct epithelium and play an important role in systemic acid-base homoeostasis…”
Get full text

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid by MANGELSDORF, D. J, BORGMEYER, U, HEYMAN, R. A, YANG ZHOU, J, ONG, E. S, ORO, A. E, KAKIZUKA, A, EVANS, R. M

“…An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems requires knowledge of the…”
Get full text