Fractal Changes of the Retinal Microvasculature in Syphilitic Uveitis

To quantify chorioretinal microvascular damage and recovery post-treatment in patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) using fractal dimension (FD). Retrospective cohort study of patients with serologically confirmed syphilitic uveitis. We obtained optical coherence t...

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Bibliographic Details
Published in:	Ocular immunology and inflammation Vol. 32; no. 9; pp. 1 - 1972
Main Authors:	Ji, Marco H, Rickels, Kaersti L, Yao, Tianyuan, Elhusseiny, Abdelrahman M, Georgiou, Michalis, Shakarchi, Ahmed F, Uwaydat, Sami B, Dare, Ryan K, Sallam, Ahmed B
Format:	Journal Article
Language:	English
Published:	England 20-10-2024
Subjects:	fractal dimension imaging biomarker Choriocapillaris syphilitic uveitis OCTA
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Summary:	To quantify chorioretinal microvascular damage and recovery post-treatment in patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) using fractal dimension (FD). Retrospective cohort study of patients with serologically confirmed syphilitic uveitis. We obtained optical coherence tomography angiography (OCTA) scans at baseline and follow-up after intravenous penicillin treatment and computed FD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using ImageJ. We enrolled seven patients with ASPPC (11 eyes), and 17 control subjects (34 eyes). Pre-treatment averages of FD-SCP, FD-DCP, and FD-CC were: 1.672 (±0.115), 1.638 (±0.097), and 1.72 (±0.137); post-treatment: 1.760 (±0.071), 1.764 (±0.043), and 1.898 (±0.047). After treatment FD-CC increased in all 11 eyes with an average of 0.163 ( = 0.003); FD-DCP increased in 10 (91%) eyes with an average of 0.126 ( = 0.003); and FD-SCP increased in seven (64%) eyes with an average of 0.089 ( = 0.059). Compared to the post-treatment FD values in the syphilitic group, controls had similar FD-SCP ( = 0.266), FD-DCP ( = 0.078), and FD-CC ( = 0.449). CC and DCP are mostly affected in ASPPC with minimal changes in the SCP. All vascular layers FD recovered after completing antibiotic treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0927-3948 1744-5078 1744-5078
DOI:	10.1080/09273948.2024.2309280