Search Results - "Uvarova, E N"

Pharmacokinetic (Bioavailability) Studies of Magnesium Preparations by Eremenko, N. N., Shikh, E. V., Uvarova, N. E.

“…In order to obtain valid results when studying the bioavailability of medicinal products containing magnesium salts, it is necessary to take into account…”
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Recommendations for the programme of clinical trials of medicinal products for the treatment of influenza by Gubenko, A. I., Shukshina, G. V., Muravieva, A. I., Uvarova, N. E.

“…Scientific relevance. The development of new medicinal products to treat influenza is motivated by the limitations of existing treatment options, the emergence…”
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Planning and Evaluation of Bioequivalence Studies of Drugs with Nonlinear Pharmacokinetics by Uvarova, N. E., Eremenko, N. N., Ramenskaya, G. V., Goryachev, D. V.

“…A bioequivalence (BE) study is one of the key stages of investigations required for the registration of oral generic drugs. The planning of this type of study…”
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Marketing Authorisation Based on Incomplete Clinical Data: International Experience and Prospects by Goryachev, D. V., Uvarova, N. E., Shukshina, G. V.

“…No new drug can be used in clinical practice without marketing authorisation. Acquisition of the necessary amount of clinical data may take several years,…”
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Evaluation of Bioequivalence of Generic Imatinib Products and Generic Tacrolimus Products Based on Indirect Comparison of the Results of Their Bioequivalence Studies by Goryachev, D. V., Uvarova, N. E.

“…Generic drugs are widely discussed in the scientific literature. Their key advantage is high availability in the medical practice due to the possibility of a…”
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Planning and Evaluation of Bioequivalence Studies of Lopinavir/Ritonavir Preparations by Uvarova, N. E., Eremenko, N. N., Ramenskaya, G. V., Goryachev, D. V.

“…Issues with planning bioequivalence studies of lopinavir/ritonavir (LPV/RTV) preparations are discussed. LPV is an antiviral (HIV) medicine and HIV protease…”
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Assessment of the Feasibility of Therapeutic Equivalence Studies by Goryachev, D. V., Uvarova, N. E.

“…The introduction of the «therapeutic equivalence» concept into the Russian legislation is critical for evaluation of medicines interchangeability and for…”
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Comparison of FDA (2018) and EAEU Regulatory Requirements for Bioanalytical Method Validation by Uvarova, N. E., Eremenko, N. N., Ramenskaya, G. V., Goryachev, D. V., Smirnov, V. V.

“…US FDA requirements published in the new 2018 guidance for bioanalytical method validation and the necessity to confirm their reliability for determining…”
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Planning and Assessment of Bioequivalence Studies of Darunavir Preparations by Uvarova, N. E., Eremenko, N. N., Ramenskaya, G. V., Goryachev, D. V.

“…Planning issues for darunavir (DRV) bioequivalence studies are considered. DRV is an antiviral (HIV) agent classified as an HIV protease inhibitor…”
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NON-BIOLOGICAL COMPLEX DRUGS CONCEPT IN GENERIC DRUGS DEVELOPMENT by D. V. Goryachev, Yu. V. Chernova, N. E. Uvarova

“…Expansion of the range of new medicines leads to a significant increase in healthcare spending and, consequently, to the appearance of more affordable generic…”
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PLANNING AND EVALUATION OF BIOEQUIVALENCE STUDIES OF ATAZANAVIR PRODUCTS by N. E. Uvarova, N. N. Eremenko, G. V. Ramenskaya, D. V. Goryachev

“…The Government of the Russian Federation approved the State strategy of combating the spread of HIV aimed at prevention of HIV epidemic. One of the goals of…”
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High-temperature resistant glass-ceramics based on Sr-anorthite and tialite phases by Orlova, L.A., Popovich, N.V., Uvarova, N.E., Paleari, A., Sarkisov, P.D.

“…We have identified a convenient strategy for the control of the thermal growth of monoclinic Sr-anorthite and tialite phases in Sr–Ti–Al–silicates. The…”
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Clustering of discrete cell properties essential for tumorigenicity and metastasis. III. Dissociation of the properties in N-ras-transfected RSV-SR-transformed cells by Deichman, G I, Topol, L Z, Kluchareva, T E, Matveeva, V A, Zakamaldina, T A, Uvarova, E N, Tatosyan, A G

“…We have previously shown that RSV-SR-transformed hamster cells acquire high resistance to H2O2, i.e. the cytotoxic product of activated macrophages (H2O2R) and…”
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Antioxidant defence mechanisms and PGE secretion by different types of transformed and tumor cells: in vivo selective advantages by Deichman, G I, Kashkina, L M, Kluchareva, T E, Matveeva, V A, Uvarova, E N, Burdelya, L G

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Generic drugs of direct antiviral action for the treatment of hepatitis C: features of bioequivalence studies by Eremenko, N. N., Uvarova, N. E., Serebrova, S. Yu, Demchenkova, E. Yu, Shikh, E. V.

“…Introduction . In the last decade, approaches to the treatment of chronic viral hepatitis C (HCV) have undergone significant changes. The new WHO strategy aims…”
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Acquisition of HP phenotype and alterations in the activity of catalase of in vitro transformed cells of different origin in the dynamics of in vivo tumor progression by Kashkina, L M, Matveeva, V A, Dyakova, N A, Uvarova, E N, Deichman, G I

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Clinical Findings in Two patients with DSD 46XY caused by new variant of the Desert Hedgehog Gene and review of the literature of the role of DHH signaling pathway in sex development by Kalinchenko, N. Y., Batyrova, Z. K., Kostrova, I. B., Kolodkina, A. A., Uvarova, E. N., Kumykova, Z. Kh, Asaturova, A. V., Khabas, G. N., Tiulpakov, A. N.

“…Mutations in the gene DHH are an extremely rare cause of disorders of sex development 46,XY (DSD,46XY). The article describes the clinical cases of two…”
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Dynamics of natural selection of tumor cells for the [H2O2CA + PGES] marker phenotype during subcutaneous growth and dissemination by D'yakova, N A, Kashkina, L M, Matveeva, V A, Uvarova, E N, Deichman, G I

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Clinical Findings in Two patients with DSD 46XY caused by new variant of the Desert Hedgehog Gene and review of the literature of the role of DHH signaling pathway in sex development by Kalinchenko, N Y, Batyrova, Z K, Kostrova, I B, Kolodkina, A A, Uvarova, E N, Kumykova, Z Kh, Asaturova, A V, Khabas, G N, Tiulpakov, A N

“…Mutations in the gene DHH are an extremely rare cause of disorders of sex development 46,XY (DSD,46XY). The article describes the clinical cases of two…”
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Sensitivity of tumor cells to the cytostatic action of natural killer cells and their ability to release prostaglandins of type E by Klyuchareva, G. E., Matveeva, V. A., Uvarova, . N.

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