Search Results - "Utset, Henry A"

B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat by Guthmiller, Jenna J, Utset, Henry A, Wilson, Patrick C

“…Antibodies are critical for providing protection against influenza virus infections. However, protective humoral immunity against influenza viruses is limited…”
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Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets by Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.

“…Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used…”
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Broadly neutralizing antibodies target a haemagglutinin anchor epitope by Guthmiller, Jenna J., Han, Julianna, Utset, Henry A., Li, Lei, Lan, Linda Yu-Ling, Henry, Carole, Stamper, Christopher T., McMahon, Meagan, O’Dell, George, Fernández-Quintero, Monica L., Freyn, Alec W., Amanat, Fatima, Stovicek, Olivia, Gentles, Lauren, Richey, Sara T., de la Peña, Alba Torrents, Rosado, Victoria, Dugan, Haley L., Zheng, Nai-Ying, Tepora, Micah E., Bitar, Dalia J., Changrob, Siriruk, Strohmeier, Shirin, Huang, Min, García-Sastre, Adolfo, Liedl, Klaus R., Bloom, Jesse D., Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Coughlan, Lynda, Ward, Andrew B., Wilson, Patrick C.

“…Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against…”
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Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses by Guthmiller, Jenna J., Lan, Linda Yu-Ling, Fernández-Quintero, Monica L., Han, Julianna, Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Stovicek, Olivia, Li, Lei, Tepora, Micah, Henry, Carole, Neu, Karlynn E., Dugan, Haley L., Borowska, Marta T., Chen, Yao-Qing, Liu, Sean T.H., Stamper, Christopher T., Zheng, Nai-Ying, Huang, Min, Palm, Anna-Karin E., García-Sastre, Adolfo, Nachbagauer, Raffael, Palese, Peter, Coughlan, Lynda, Krammer, Florian, Ward, Andrew B., Liedl, Klaus R., Wilson, Patrick C.

“…Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon…”
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Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike by Changrob, Siriruk, Fu, Yanbin, Guthmiller, Jenna J, Halfmann, Peter J, Li, Lei, Stamper, Christopher T, Dugan, Haley L, Accola, Molly, Rehrauer, William, Zheng, Nai-Ying, Huang, Min, Wang, Jiaolong, Erickson, Steven A, Utset, Henry A, Graves, Hortencia M, Amanat, Fatima, Sather, D Noah, Krammer, Florian, Kawaoka, Yoshihiro, Wilson, Patrick C

“…Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have arisen that exhibit increased viral transmissibility and partial evasion of…”
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An Egg-Derived Sulfated N -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines by Guthmiller, Jenna J, Utset, Henry A, Henry, Carole, Li, Lei, Zheng, Nai-Ying, Sun, Weina, Costa Vieira, Marcos, Zost, Seth, Huang, Min, Hensley, Scott E, Cobey, Sarah, Palese, Peter, Wilson, Patrick C

“…Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation…”
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Bridging the B Cell Gap: Novel Technologies to Study Antigen-Specific Human B Cell Responses by Utset, Henry A., Guthmiller, Jenna J., Wilson, Patrick C.

“…The generation of high affinity antibodies is a crucial aspect of immunity induced by vaccination or infection. Investigation into the B cells that produce…”
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Improved integration of single-cell transcriptome and surface protein expression by LinQ-View by Li, Lei, Dugan, Haley L., Stamper, Christopher T., Lan, Linda Yu-Ling, Asby, Nicholas W., Knight, Matthew, Stovicek, Olivia, Zheng, Nai-Ying, Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Changrob, Siriruk, Utset, Henry A., Henry, Carole, Nelson, Christopher, Jedrzejczak, Robert P., Fremont, Daved H., Joachimiak, Andrzej, Krammer, Florian, Huang, Jun, Khan, Aly A., Wilson, Patrick C.

“…Multimodal advances in single-cell sequencing have enabled the simultaneous quantification of cell surface protein expression alongside unbiased…”
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Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals by Henry, Carole, Zheng, Nai-Ying, Huang, Min, Cabanov, Alexandra, Rojas, Karla Thatcher, Kaur, Kaval, Andrews, Sarah F., Palm, Anna-Karin E., Chen, Yao-Qing, Li, Yang, Hoskova, Katerina, Utset, Henry A., Vieira, Marcos C., Wrammert, Jens, Ahmed, Rafi, Holden-Wiltse, Jeanne, Topham, David J., Treanor, John J., Ertl, Hildegund C., Schmader, Kenneth E., Cobey, Sarah, Krammer, Florian, Hensley, Scott E., Greenberg, Harry, He, Xiao-Song, Wilson, Patrick C.

“…Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated…”
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Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans by Dugan, Haley L, Guthmiller, Jenna J, Arevalo, Philip, Huang, Min, Chen, Yao-Qing, Neu, Karlynn E, Henry, Carole, Zheng, Nai-Ying, Lan, Linda Yu-Ling, Tepora, Micah E, Stovicek, Olivia, Bitar, Dalia, Palm, Anna-Karin E, Stamper, Christopher T, Changrob, Siriruk, Utset, Henry A, Coughlan, Lynda, Krammer, Florian, Cobey, Sarah, Wilson, Patrick C

“…Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a result, preexisting influenza-specific memory B cells can dominate…”
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First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes by Guthmiller, Jenna J, Han, Julianna, Li, Lei, Freyn, Alec W, Liu, Sean T H, Stovicek, Olivia, Stamper, Christopher T, Dugan, Haley L, Tepora, Micah E, Utset, Henry A, Bitar, Dalia J, Hamel, Natalie J, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Krammer, Florian, Nachbagauer, Raffael, Palese, Peter, Ward, Andrew B, Wilson, Patrick C

“…Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009…”
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Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study by Henry, Carole, Palm, Anna-Karin E, Utset, Henry A, Huang, Min, Ho, Irvin Y, Zheng, Nai-Ying, Fitzgerald, Theresa, Neu, Karlynn E, Chen, Yao-Qing, Krammer, Florian, Treanor, John J, Sant, Andrea J, Topham, David J, Wilson, Patrick C

“…Vaccination is the best measure of protection against influenza virus infection. Vaccine-induced antibody responses target mainly the hemagglutinin (HA)…”
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