Search Results - "Utkin, N. N."

Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery by Utkin, Yuri N.

“…Three-finger toxins (TFTs) are the main venom components of snakes from Elapidae family. Amino acid sequences of more than five hundreds TFTs are determined;…”
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Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms by Kini, R. Manjunatha, Utkin, Yuri N.

“…In many animals belonging to different taxa, venoms evolved as a means of defense and/or a means of attack/hunting [...]…”
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Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins by Dubovskii, Peter V, Utkin, Yuri N

“…Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom. Our analysis of the available CT amino acid sequences, literature data…”
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Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy by Kalita, Bhargab, Utkin, Yuri N, Mukherjee, Ashis K

“…Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass…”
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Cardiovascular Effects of Snake Toxins: Cardiotoxicity and Cardioprotection by Averin, Alexey S., Utkin, Yuri N.

“…Snake venoms, as complex mixtures of peptides and proteins, affect various vital systems of the organism. One of the main targets of the toxic components from…”
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Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types by Averin, Alexey S, Berezhnov, Alexey V, Pimenov, Oleg Y, Galimova, Miliausha H, Starkov, Vladislav G, Tsetlin, Victor I, Utkin, Yuri N

“…Cardiotoxins (CaTx) of the three-finger toxin family are one of the main components of cobra venoms. Depending on the structure of the N-terminal or the…”
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Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop by Dubovskii, Peter V, Ignatova, Anastasia A, Alekseeva, Anna S, Starkov, Vladislav G, Boldyrev, Ivan A, Feofanov, Alexey V, Utkin, Yuri N

“…In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans…”
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Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms by Averin, Alexey S, Nenov, Miroslav N, Starkov, Vladislav G, Tsetlin, Victor I, Utkin, Yuri N

“…Cardiotoxins (CaTxs) are a group of snake toxins that affect the cardiovascular system (CVS). Two types (S and P) of CaTxs are known, but the exact differences…”
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Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling by Dubovskii, Peter V, Dubova, Kira M, Bourenkov, Gleb, Starkov, Vladislav G, Konshina, Anastasia G, Efremov, Roman G, Utkin, Yuri N, Samygina, Valeriya R

“…Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from cobra venom (CT13Nn). For…”
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Defects of intensive care of patients with COVID-19. Expert doctors and opinion by Gorbachev, V. I., Utkin, N. N., Netesin, E. S., Shapovalov, K. G., Gorbacheva, S. M., Dunts, P. V., Ershov, V. I.

“…Background . A significant proportion of patients infected with the SARS-CoV-2 virus had a severe course of the disease required hospitalization and intensive…”
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Antiproliferative activity of cobra venom cytotoxins by Dubovskii, Peter V, Utkin, Yuri N

“…Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family. They comprise about 60 amino acid residues,…”
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Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors by Vulfius, Catherine A, Kasheverov, Igor E, Kryukova, Elena V, Spirova, Ekaterina N, Shelukhina, Irina V, Starkov, Vladislav G, Andreeva, Tatyana V, Faure, Grazyna, Zouridakis, Marios, Tsetlin, Victor I, Utkin, Yuri N

“…Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and…”
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α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors by Osipov, Alexey V, Terpinskaya, Tatiana I, Yanchanka, Tatsiana, Balashevich, Tatjana, Zhmak, Maxim N, Tsetlin, Victor I, Utkin, Yuri N

“…Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased…”
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α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells by Terpinskaya, Tatiana I, Osipov, Alexey V, Kryukova, Elena V, Kudryavtsev, Denis S, Kopylova, Nina V, Yanchanka, Tatsiana L, Palukoshka, Alena F, Gondarenko, Elena A, Zhmak, Maxim N, Tsetlin, Victor I, Utkin, Yuri N

“…Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the…”
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Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression by Siniavin, Andrei E, Streltsova, Maria A, Kudryavtsev, Denis S, Shelukhina, Irina V, Utkin, Yuri N, Tsetlin, Victor I

“…Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both…”
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Hyperfine Interactions in Dichalcogenides CrxNbSe2 (x = 0.33, 0.5): A 93Nb NMR Study by Smolnikov, A. G., Piskunov, Yu. V., Ogloblichev, V. V., Sadykov, A. F., Kashnikova, M. E., Utkin, N. A., Gerashchenko, A. P., Akramov, D. F., Selezneva, N. V., Baranov, N. V.

“…For the first time, an 93 Nb NMR study of dichalcogenides Cr x NbSe 2 ( x = 0.33, 0.5) in the paramagnetic state was performed. Analysis of the 93 Nb NMR…”
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Editorial: Venoms, Animal and Microbial Toxins by Cao, Zhijian, Wang, Jing-Lin, McNutt, Patrick Michael, Utkin, Yuri N., Shahbazzadeh, Delavar, Wulff, Heike, Kovacic, Hervé, Sabatier, Jean-Marc

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Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids by Konshina, Anastasia G, Boldyrev, Ivan A, Utkin, Yuri N, Omel'kov, Anton V, Efremov, Roman G

“…The major representatives of Elapidae snake venom, cytotoxins (CTs), share similar three-fingered fold and exert diverse range of biological activities against…”
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From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs by Kryukova, Elena V, Egorova, Natalia S, Kudryavtsev, Denis S, Lebedev, Dmitry S, Spirova, Ekaterina N, Zhmak, Maxim N, Garifulina, Aleksandra I, Kasheverov, Igor E, Utkin, Yuri N, Tsetlin, Victor I

“…The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of…”
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Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia by Severyukhina, M. S., Ismailova, A. M., Shaykhutdinova, E. R., Dyachenko, I. A., Egorova, N. S., Murashev, A. N., Tsetlin, V. I., Utkin, Yu. N.

“…Previously, it was shown that the non-conventional toxin WTX from the venom of the cobra Naja kaouthia , when administered intravenously, caused a decrease in…”
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