Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic con...

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Published in:Phytotherapy research Vol. 33; no. 12; pp. 3112 - 3128
Main Authors: Ahamad, Javed, Toufeeq, Ibrahim, Khan, Mohammad Ahmed, Ameen, Muath Sh. Mohammed, Anwer, Esra T., Uthirapathy, Subha, Mir, Showkat R., Ahmad, Javed
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-12-2019
Subjects:
Adolescent
Adult
Antidiabetics
Antihypertensives
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
cardiovascular disease
chemistry
diabetes
Diabetes mellitus
Dyslipidemia
Fruit trees
Humans
Iridoids - pharmacology
Iridoids - therapeutic use
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - diet therapy
obesity
Oils & fats
Olea europaea L
Oleuropein
Organic chemistry
Phenolic compounds
Phenols
Young Adult
Olea europaea L
chemistry
metabolic syndrome
cardiovascular disease
oleuropein
diabetes
obesity
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Summary:Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6511