Fruit-juice concentrate of Asian plum inhibits growth signals of vascular smooth muscle cells induced by angiotensin II

Bainiku-ekisu, the fruit-juice concentrate of the Oriental plum ( Prunus mume) has recently been shown to improve human blood fluidity. We have shown that angiotensin II (AngII) stimulates growth of vascular smooth muscle cells (VSMCs) through epidermal growth factor (EGF) receptor transactivation t...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 72; no. 6; pp. 659 - 667
Main Authors:	Utsunomiya, Hirotoshi, Takekoshi, Susumu, Gato, Nobuki, Utatsu, Hisao, Motley, Evangeline D, Eguchi, Kunie, Fitzgerald, Trinita G, Mifune, Mizuo, Frank, Gerald D, Eguchi, Satoru
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 27-12-2002
Subjects:	Angiotensin II Angiotensin II - pharmacology Animals Calcium - metabolism Cells, Cultured Citric Acid - analogs & derivatives Citric Acid - isolation & purification Citric Acid - pharmacology Dose-Response Relationship, Drug EGF receptor ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Furans - isolation & purification Furans - pharmacology Lipid Peroxidation Microsomes, Liver - drug effects Microsomes, Liver - metabolism Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Plant Extracts - isolation & purification Plant Extracts - pharmacology Plum Protein Biosynthesis Prunus Rats Rats, Sprague-Dawley Rats, Wistar Signal Transduction Transcriptional Activation Vascular smooth muscle cell Signal transduction Vascular smooth muscle cell EGF receptor Plum Angiotensin II
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Summary:	Bainiku-ekisu, the fruit-juice concentrate of the Oriental plum ( Prunus mume) has recently been shown to improve human blood fluidity. We have shown that angiotensin II (AngII) stimulates growth of vascular smooth muscle cells (VSMCs) through epidermal growth factor (EGF) receptor transactivation that involves reactive oxygen species (ROS) production. To better understanding the possible cardiovascular protective effect of Bainiku-ekisu, we have studied whether Bainiku-ekisu inhibits AngII-induced growth promoting signals in VSMCs. Bainiku-ekisu markedly inhibited AngII-induced EGF receptor transactivation. H 2O 2-induced EGF receptor transactivation was also inhibited by Bainiku-ekisu. Thus, Bainiku-ekisu markedly inhibited AngII-induced extracellular signal-regulated kinase (ERK) activation. However, EGF-induced ERK activation was not affected by Bainiku-ekisu. AngII stimulated leucine uptake in VSMCs that was significantly inhibited by Bainiku-ekisu. Also, Bainiku-ekisu possesses a potent antioxidant activity. Since the activation of EGF receptor, ERK and the production of ROS play central roles in mediating AngII-induced vascular remodeling, these data suggest that Bainiku-ekisu could exert a powerful cardiovascular protective effect with regard to cardiovascular diseases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-3205 1879-0631
DOI:	10.1016/S0024-3205(02)02300-7