Search Results - "Uta Dirksen"

Rhabdomyosarcoma, Ewing Sarcoma, and Other Round Cell Sarcomas by Pappo, Alberto S, Dirksen, Uta

“…Several recent advances have been made in the diagnosis and therapy of malignant small round cell tumors that affect children, particularly in…”
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Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden by Peneder, Peter, Stütz, Adrian M., Surdez, Didier, Krumbholz, Manuela, Semper, Sabine, Chicard, Mathieu, Sheffield, Nathan C., Pierron, Gaelle, Lapouble, Eve, Tötzl, Marcus, Ergüner, Bekir, Barreca, Daniele, Rendeiro, André F., Agaimy, Abbas, Boztug, Heidrun, Engstler, Gernot, Dworzak, Michael, Bernkopf, Marie, Taschner-Mandl, Sabine, Ambros, Inge M., Myklebost, Ola, Marec-Bérard, Perrine, Burchill, Susan Ann, Brennan, Bernadette, Strauss, Sandra J., Whelan, Jeremy, Schleiermacher, Gudrun, Schaefer, Christiane, Dirksen, Uta, Hutter, Caroline, Boye, Kjetil, Ambros, Peter F., Delattre, Olivier, Metzler, Markus, Bock, Christoph, Tomazou, Eleni M.

“…Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment…”
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Ewing Sarcoma: Current Management and Future Approaches Through Collaboration by Gaspar, Nathalie, Hawkins, Douglas S, Dirksen, Uta, Lewis, Ian J, Ferrari, Stefano, Le Deley, Marie-Cecile, Kovar, Heinrich, Grimer, Robert, Whelan, Jeremy, Claude, Line, Delattre, Olivier, Paulussen, Michael, Picci, Piero, Sundby Hall, Kirsten, van den Berg, Hendrik, Ladenstein, Ruth, Michon, Jean, Hjorth, Lars, Judson, Ian, Luksch, Roberto, Bernstein, Mark L, Marec-Bérard, Perrine, Brennan, Bernadette, Craft, Alan W, Womer, Richard B, Juergens, Heribert, Oberlin, Odile

“…Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak incidence in adolescents and young adults. The treatment…”
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Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial by Ladenstein, Ruth, Pötschger, Ulrike, Le Deley, Marie Cécile, Whelan, Jeremy, Paulussen, Michael, Oberlin, Odile, van den Berg, Henk, Dirksen, Uta, Hjorth, Lars, Michon, Jean, Lewis, Ian, Craft, Alan, Jürgens, Heribert

“…To improve the poor prognosis of patients with primary disseminated multifocal Ewing sarcomas (PDMES) with a dose-intense treatment concept. From 1999 to 2005,…”
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Preliminary Efficacy of the Anti-Insulin–Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma by JUERGENS, Heribert, DAW, Najat C, TAO WANG, GREEN, Stephanie, PACCAGNELLA, Luisa, GUALBERTO, Antonio, GEOERGER, Birgit, FERRARI, Stefano, VILLARROEL, Milena, AERTS, Isabelle, WHELAN, Jeremy, DIRKSEN, Uta, HIXON, Mary L, DONGHUA YIN

“…Patients with Ewing sarcoma (ES) with metastases and those who relapse fare poorly and receive therapies that carry significant toxicity. This phase 1/2 study…”
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Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium by Skinner, Roderick, Prof, Mulder, Renee L, PhD, Kremer, Leontien C, PhD, Hudson, Melissa M, Prof, Constine, Louis S, Prof, Bardi, Edit, PhD, Boekhout, Annelies, PhD, Borgmann-Staudt, Anja, MD, Brown, Morven C, MSc, Cohn, Richard, Prof, Dirksen, Uta, Prof, Giwercman, Alexsander, Prof, Ishiguro, Hiroyuki, MD, Jahnukainen, Kirsi, PhD, Kenney, Lisa B, Prof, Loonen, Jacqueline J, PhD, Meacham, Lilian, Prof, Neggers, Sebastian, PhD, Nussey, Stephen, Prof, Petersen, Cecilia, PhD, Shnorhavorian, Margarett, MD, van den Heuvel-Eibrink, Marry M, Prof, van Santen, Hanneke M, MD, Wallace, William H B, Prof, Green, Daniel M, Prof

“…Summary Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs can cause impaired spermatogenesis, testosterone deficiency,…”
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Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma by Krumbholz, Manuela, Hellberg, Julia, Steif, Benedikt, Bäuerle, Tobias, Gillmann, Clarissa, Fritscher, Torsten, Agaimy, Abbas, Frey, Benjamin, Juengert, Joerg, Wardelmann, Eva, Hartmann, Wolfgang, Juergens, Heribert, Dirksen, Uta, Metzler, Markus

“…The application of the tumor-specific genomic fusion sequence as noninvasive biomarker for therapy monitoring in Ewing sarcoma (EwS) has been evaluated. EwS…”
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Which Factors Are Associated with Local Control and Survival of Patients with Localized Pelvic Ewing’s Sarcoma? A Retrospective Analysis of Data from the Euro-EWING99 Trial by Andreou, Dimosthenis, Ranft, Andreas, Gosheger, Georg, Timmermann, Beate, Ladenstein, Ruth, Hartmann, Wolfgang, Bauer, Sebastian, Baumhoer, Daniel, van den Berg, Henk, Dijkstra, P.D. Sander, Dürr, Hans Roland, Gelderblom, Hans, Hardes, Jendrik, Hjorth, Lars, Kreyer, Justus, Kruseova, Jarmila, Leithner, Andreas, Scobioala, Sergiu, Streitbürger, Arne, Tunn, Per-Ulf, Wardelmann, Eva, Windhager, Reinhard, Jürgens, Heribert, Dirksen, Uta

“…Local treatment of pelvic Ewing's sarcoma may be challenging, and intergroup studies have focused on improving systemic treatments rather than prospectively…”
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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing by Selvanathan, Saravana P., Graham, Garrett T., Erkizan, Hayriye V., Dirksen, Uta, Natarajan, Thanemozhi G., Dakic, Aleksandra, Yu, Songtao, Liu, Xuefeng, Paulsen, Michelle T., Ljungman, Mats E., Wu, Cathy H., Lawlor, Elizabeth R., Üren, Aykut, Toretsky, Jeffrey A.

“…Significance Alternative splicing of RNA allows a limited number of coding regions in the human genome to produce proteins with diverse functionality…”
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Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility by Machiela, Mitchell J., Grünewald, Thomas G. P., Surdez, Didier, Reynaud, Stephanie, Mirabeau, Olivier, Karlins, Eric, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetete-Lalami, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Michon, Jean, Pierron, Gaelle, Kovar, Heinrich, Gaspar, Nathalie, Kontny, Udo, González-Neira, Anna, Picci, Piero, Alonso, Javier, Patino-Garcia, Ana, Corradini, Nadège, Bérard, Perrine Marec, Freedman, Neal D., Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Jones, Kristine, Manning, Michelle, Wyatt, Kathleen, Zhou, Weiyin, Yeager, Meredith, Cox, David G., Hoover, Robert N., Khan, Javed, Armstrong, Gregory T., Leisenring, Wendy M., Bhatia, Smita, Robison, Leslie L., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Metzler, Markus, Hartmann, Wolfgang, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Morton, Lindsay M., Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Chanock, Stephen J., Delattre, Olivier

“…Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1 - FLI1 fusion. We performed a genome-wide association study of 733 EWS cases and 1346…”
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Defining a Characteristic Gene Expression Set Responsible for Cancer Stem Cell-Like Features in a Sub-Population of Ewing Sarcoma Cells CADO-ES1 by Hotfilder, Marc, Mallela, Nikhil, Seggewiß, Jochen, Dirksen, Uta, Korsching, Eberhard

“…One of the still open questions in Ewing sarcoma, a rare bone tumor with weak therapeutic options, is to identify the tumor-driving cell (sub) population and…”
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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer by Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

“…Chromosomal instability (CIN) is a hallmark of cancer 1 . Yet, many childhood cancers, such as Ewing sarcoma (EwS), feature remarkably ‘silent’ genomes with…”
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The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling by Berning, Philipp, Schaefer, Christiane, Clemens, Dagmar, Korsching, Eberhard, Dirksen, Uta, Potratz, Jenny

“…The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction…”
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Number of metastases and their response to chemotherapy impact survival of patients with isolated lung metastases from bone-derived sarcoma by Stork, Theresa, Boemans, Rebecca, Hardes, Jendrik, Streitbürger, Arne, Dirksen, Uta, Pöttgen, Christoph, Schildhaus, Hans-Ulrich, Bauer, Sebastian, Collaud, Stéphane, Aigner, Clemens

“…Pulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas. The aim of this study was to examine our…”
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Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm by Schaefer, Christiane, Mallela, Nikhil, Seggewiß, Jochen, Lechtape, Birgit, Omran, Heymut, Dirksen, Uta, Korsching, Eberhard, Potratz, Jenny

“…In the search for novel therapeutic targets, RNA interference screening has become a valuable tool. High-throughput technologies are now broadly accessible but…”
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68Ga-FAPI as a Diagnostic Tool in Sarcoma: Data from the 68Ga-FAPI PET Prospective Observational Trial by Kessler, Lukas, Ferdinandus, Justin, Hirmas, Nader, Bauer, Sebastian, Dirksen, Uta, Zarrad, Fadi, Nader, Michael, Chodyla, Michal, Milosevic, Aleksandar, Umutlu, Lale, Schuler, Martin, Podleska, Lars Erik, Schildhaus, Hans-Ulrich, Fendler, Wolfgang P, Hamacher, Rainer

“…Bone and soft-tissue sarcomas express fibroblast activation protein (FAP) on tumor cells and associated fibroblasts. Therefore, FAP is a promising therapeutic…”
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Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets by Baldauf, Michaela C, Orth, Martin F, Dallmayer, Marlene, Marchetto, Aruna, Gerke, Julia S, Rubio, Rebeca Alba, Kiran, Merve M, Musa, Julian, Knott, Maximilian M L, Ohmura, Shunya, Li, Jing, Akpolat, Nusret, Akatli, Ayse N, Özen, Özlem, Dirksen, Uta, Hartmann, Wolfgang, de Alava, Enrique, Baumhoer, Daniel, Sannino, Giuseppina, Kirchner, Thomas, Grünewald, Thomas G P

“…Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic fusions such as enables definitive diagnosis,…”
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Proton Therapy for Primary Bone Malignancy of the Pelvic and Lumbar Region - Data From the Prospective Registries ProReg and KiProReg by Worawongsakul, Rasin, Steinmeier, Theresa, Lin, Yi-Lan, Bauer, Sebastian, Hardes, Jendrik, Hecker-Nolting, Stefanie, Dirksen, Uta, Timmermann, Beate

“…Multimodality treatments together with local proton therapy (PT) are commonly used in unresectable primary bone malignancies in order to provide better tumor…”
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Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity-Results from the Pilot Randomized Controlled Trial proGAIT by Basteck, Simon, Guder, Wiebke K, Dirksen, Uta, Krombholz, Arno, Streitbürger, Arne, Reinhardt, Dirk, Götte, Miriam

“…Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait…”
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Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies by Berger, Manfred, Dirksen, Uta, Braeuninger, Andreas, Koehler, Gabriele, Juergens, Heribert, Krumbholz, Manuela, Metzler, Markus

“…Chromosomal translocations between the EWS gene and members of the ETS gene family are characteristic molecular features of the Ewing sarcoma. The most common…”
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