Search Results - "Ustinov, Jarkko"

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes by Balboa, Diego, Saarimäki-Vire, Jonna, Borshagovski, Daniel, Survila, Mantas, Lindholm, Päivi, Galli, Emilia, Eurola, Solja, Ustinov, Jarkko, Grym, Heli, Huopio, Hanna, Partanen, Juha, Wartiovaara, Kirmo, Otonkoski, Timo

“…Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This…”
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MANF protects human pancreatic beta cells against stress-induced cell death by Hakonen, Elina, Chandra, Vikash, Fogarty, Christopher L., Yu, Nancy Yiu-Lin, Ustinov, Jarkko, Katayama, Shintaro, Galli, Emilia, Danilova, Tatiana, Lindholm, Päivi, Vartiainen, Aki, Einarsdottir, Elisabet, Krjutškov, Kaarel, Kere, Juha, Saarma, Mart, Lindahl, Maria, Otonkoski, Timo

“…Aims/hypothesis There is a great need to identify factors that could protect pancreatic beta cells against apoptosis or stimulate their replication and thus…”
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MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells by Lindahl, Maria, Danilova, Tatiana, Palm, Erik, Lindholm, Päivi, Võikar, Vootele, Hakonen, Elina, Ustinov, Jarkko, Andressoo, Jaan-Olle, Harvey, Brandon K., Otonkoski, Timo, Rossi, Jari, Saarma, Mart

“…All forms of diabetes mellitus (DM) are characterized by the loss of functional pancreatic β cell mass, leading to insufficient insulin secretion. Thus,…”
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Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets by Barsby, Tom, Vähäkangas, Eliisa, Ustinov, Jarkko, Montaser, Hossam, Ibrahim, Hazem, Lithovius, Väinö, Kuuluvainen, Emilia, Chandra, Vikash, Saarimäki-Vire, Jonna, Katajisto, Pekka, Hietakangas, Ville, Otonkoski, Timo

“…Pancreatic islets regulate blood glucose homeostasis through the controlled release of insulin; however, current metabolic models of glucose-sensitive insulin…”
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An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation by Saarimäki-Vire, Jonna, Balboa, Diego, Russell, Mark A., Saarikettu, Juha, Kinnunen, Matias, Keskitalo, Salla, Malhi, Amrinder, Valensisi, Cristina, Andrus, Colin, Eurola, Solja, Grym, Heli, Ustinov, Jarkko, Wartiovaara, Kirmo, Hawkins, R. David, Silvennoinen, Olli, Varjosalo, Markku, Morgan, Noel G., Otonkoski, Timo

“…Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have…”
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EGFR signaling promotes β-cell proliferation and survivin expression during pregnancy by Hakonen, Elina, Ustinov, Jarkko, Palgi, Jaan, Miettinen, Päivi J, Otonkoski, Timo

“…Placental lactogen (PL) induced serotonergic signaling is essential for gestational β-cell mass expansion. We have previously shown that intact Epidermal…”
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A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation by Vuoristo, Sanna, Toivonen, Sanna, Weltner, Jere, Mikkola, Milla, Ustinov, Jarkko, Trokovic, Ras, Palgi, Jaan, Lund, Riikka, Tuuri, Timo, Otonkoski, Timo

“…Correct interactions with extracellular matrix are essential to human pluripotent stem cells (hPSC) to maintain their pluripotent self-renewal capacity during…”
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A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1 by SHIMOMURA, Kenju, TUSA, Maija, USTINOV, Jarkko, OTONKOSKI, Timo, LAAKSO, Markku, ASHCROFT, Frances M, IBERL, Michaela, BRERETON, Melissa F, KAIZIK, Stephan, PROKS, Peter, LAHMANN, Carolina, YALURI, Nagendra, MODI, Shalem, HUOPIO, Hanna

“…Loss-of-function mutations in the KATP channel genes KCNJ11 and ABCC8 cause neonatal hyperinsulinism in humans. Dominantly inherited mutations cause less…”
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Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture by Gao, Ru, Ustinov, Jarkko, Pulkkinen, Mari-Anne, Lundin, Karolina, Korsgren, Olle, Otonkoski, Timo

“…Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture Ru Gao 1 , Jarkko Ustinov…”
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Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy by Lehtonen, Sanna, Miettinen, Päivi J., Jalanko, Hannu, Havana, Marika, Ustinov, Jarkko, Lehtonen, Eero, Tienari, Jukka, Dumont, Vincent, Hyvönen, Mervi E., Otonkoski, Timo

“…The transgenic E1-DN mice express a kinase-negative epidermal growth factor receptor in their pancreatic islets and are diabetic from two weeks of age due to…”
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Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth by MIETTINEN, Päivi J, USTINOV, Jarkko, ORMIO, Päivi, RU GAO, PALGI, Jaan, HAKONEN, Elina, JUNTTI-BERGGREN, Lisa, BERGGREN, Per-Olof, OTONKOSKI, Timo

“…Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth Päivi J. Miettinen 1 2 , Jarkko Ustinov 1…”
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Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release by OTONKOSKI, Timo, KAMINEN, Nina, USTINOV, Jarkko, LAPATTO, Risto, MEISSNER, Thomas, MAYATEPEK, Ertan, KERE, Juha, SIPILÄ, Ilkka

“…Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release Timo…”
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Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors by Miettinen, P J, Huotari, M, Koivisto, T, Ustinov, J, Palgi, J, Rasilainen, S, Lehtonen, E, Keski-Oja, J, Otonkoski, T

“…Pancreatic acini and islets are believed to differentiate from common ductal precursors through a process requiring various growth factors. Epidermal growth…”
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Maturation of in vitro-generated human islets after transplantation in nude mice by Gao, Ru, Ustinov, Jarkko, Korsgren, Olle, Mikkola, Milla, Lundin, Karolina, Otonkoski, Timo

“…The long-term function of human pancreatic islet grafts may depend on the neogenesis of beta cells from epithelial precursors within the grafted tissue. We…”
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells by Balboa, Diego, Barsby, Tom, Lithovius, Väinö, Saarimäki-Vire, Jonna, Omar-Hmeadi, Muhmmad, Dyachok, Oleg, Montaser, Hossam, Lund, Per-Eric, Yang, Mingyu, Ibrahim, Hazem, Näätänen, Anna, Chandra, Vikash, Vihinen, Helena, Jokitalo, Eija, Kvist, Jouni, Ustinov, Jarkko, Nieminen, Anni I., Kuuluvainen, Emilia, Hietakangas, Ville, Katajisto, Pekka, Lau, Joey, Carlsson, Per-Ola, Barg, Sebastian, Tengholm, Anders, Otonkoski, Timo

“…Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation…”
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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function by Ibrahim, Hazem, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Dyachok, Oleg, Lund, Per-Eric, Omar-Hmeadi, Muhmmad, Kvist, Jouni, Dwivedi, Om P., Lithovius, Väinö, Barsby, Tom, Chandra, Vikash, Eurola, Solja, Ustinov, Jarkko, Tuomi, Tiinamaija, Miettinen, Päivi J., Barg, Sebastian, Tengholm, Anders, Otonkoski, Timo

“…Aims/hypothesis Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7 is…”
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Activin A and Wnt-dependent specification of human definitive endoderm cells by Toivonen, Sanna, Lundin, Karolina, Balboa, Diego, Ustinov, Jarkko, Tamminen, Kaisa, Palgi, Jaan, Trokovic, Ras, Tuuri, Timo, Otonkoski, Timo

“…Activin/Nodal and Wnt signaling are known to play important roles in the regional specification of endoderm. Here we have investigated the effect of the length…”
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Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets by Tyrberg, Björn, Ustinov, Jarkko, Otonkoski, Timo, Andersson, Arne

“…Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets Effects of the ob Gene and Compensatory Growth of the…”
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In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes by Hakonen, Elina, Ustinov, Jarkko, Eizirik, Décio L., Sariola, Hannu, Miettinen, Päivi J., Otonkoski, Timo

“…Aims/hypothesis EGF receptor (EGFR) signalling is required for normal beta cell development and postnatal beta cell proliferation. We tested whether beta cell…”
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sept7b is required for the differentiation of pancreatic endocrine progenitors by Dash, Surjya Narayan, Hakonen, Elina, Ustinov, Jarkko, Otonkoski, Timo, Andersson, Olov, Lehtonen, Sanna

“…Protection or restoration of pancreatic β-cell mass as a therapeutic treatment for type 1 diabetes requires understanding of the mechanisms that drive the…”
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