Search Results - "Ustianenko, Dmytro"
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Precise temporal regulation of alternative splicing during neural development
Published in Nature communications (06-06-2018)“…Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated during neurodevelopment. However, the precise timing of…”
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TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs
Published in The EMBO journal (17-10-2016)“…Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are…”
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Structure-based prediction and characterization of photo-crosslinking in native protein–RNA complexes
Published in Nature communications (13-03-2024)“…UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA complexes while our understanding of the photo-crosslinking…”
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Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
Published in RNA (Cambridge) (01-12-2013)“…The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained…”
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CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
Published in Nature communications (07-05-2024)“…Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides…”
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Microexons: discovery, regulation, and function
Published in Wiley interdisciplinary reviews. RNA (01-07-2017)“…The importance of RNA splicing in numerous cellular processes is well established. However, an underappreciated aspect is the ability of the spliceosome to…”
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LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs
Published in Molecular cell (19-07-2018)“…LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits the biogenesis of let-7 microRNAs to regulate development and influence disease…”
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Brain Translation: A Feather Tips the Scale
Published in Molecular cell (19-03-2020)“…In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific microexon in eIF4G translation initiation factors that dampens…”
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