Search Results - "Usiello, A."

Caffeine as a psychomotor stimulant: mechanism of action by Fisone, G, Borgkvist, A, Usiello, A

“…The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which depend on its ability to reduce adenosine transmission in the…”
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Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice by Guida, F., Turco, F., Iannotta, M., De Gregorio, D., Palumbo, I., Sarnelli, G., Furiano, A., Napolitano, F., Boccella, S., Luongo, L., Mazzitelli, M., Usiello, A., De Filippis, F., Iannotti, F.A., Piscitelli, F., Ercolini, D., de Novellis, V., Di Marzo, V., Cuomo, R., Maione, S.

“…•Microbiota perturbation causes depression and biochemical and functional alterations.•Gut Lachnospiraceae and endocannabinoids levels correlate negatively…”
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Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in L-DOPA-Induced Dyskinesia by Santini, Emanuela, Valjent, Emmanuel, Usiello, Alessandro, Carta, Manolo, Borgkvist, Anders, Girault, Jean-Antoine, Herve, Denis, Greengard, Paul, Fisone, Gilberto

“…The molecular basis of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's…”
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The A1 adenosine receptor as a new player in microglia physiology by Luongo, L., Guida, F., Imperatore, R., Napolitano, F., Gatta, L., Cristino, L., Giordano, C., Siniscalco, D., Di Marzo, V., Bellini, G., Petrelli, R., Cappellacci, L., Usiello, A., de Novellis, V., Rossi, F., Maione, S.

“…The purinergic system is highly involved in the regulation of microglial physiological processes. In addition to the accepted roles for the P2X4,7 and P2Y12…”
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Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice by Guida, F, Luongo, L, Marmo, F, Romano, R, Iannotta, M, Napolitano, F, Belardo, C, Marabese, I, D'Aniello, A, De Gregorio, D, Rossi, F, Piscitelli, F, Lattanzi, R, de Bartolomeis, A, Usiello, A, Di Marzo, V, de Novellis, V, Maione, S

“…Enhanced supraspinal glutamate levels following nerve injury are associated with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain…”
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Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia by Lundblad, M., Usiello, A., Carta, M., Håkansson, K., Fisone, G., Cenci, M.A.

“…Dyskinesia (abnormal involuntary movements) is a common complication of l-DOPA pharmacotherapy in Parkinson's disease, and is thought to depend on abnormal…”
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Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis by Grasselli, G, Rossi, S, Musella, A, Gentile, A, Loizzo, S, Muzio, L, Di Sanza, C, Errico, F, Musumeci, G, Haji, N, Fresegna, D, Sepman, H, De Chiara, V, Furlan, R, Martino, G, Usiello, A, Mandolesi, G, Centonze, D

“…Background and Purpose Glutamate transmission is dysregulated in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the animal…”
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A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice by Errico, F, D'Argenio, V, Sforazzini, F, Iasevoli, F, Squillace, M, Guerri, G, Napolitano, F, Angrisano, T, Di Maio, A, Keller, S, Vitucci, D, Galbusera, A, Chiariotti, L, Bertolino, A, de Bartolomeis, A, Salvatore, F, Gozzi, A, Usiello, A

“…Increasing evidence points to a role for dysfunctional glutamate N -methyl- D -aspartate receptor (NMDAR) neurotransmission in schizophrenia. D -aspartate is…”
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Dysfunctional dopaminergic neurotransmission in asocial BTBR mice by Squillace, M, Dodero, L, Federici, M, Migliarini, S, Errico, F, Napolitano, F, Krashia, P, Di Maio, A, Galbusera, A, Bifone, A, Scattoni, M L, Pasqualetti, M, Mercuri, N B, Usiello, A, Gozzi, A

“…Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by pronounced social and communication deficits and stereotyped behaviours…”
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Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals by Errico, F, Nisticò, R, Di Giorgio, A, Squillace, M, Vitucci, D, Galbusera, A, Piccinin, S, Mango, D, Fazio, L, Middei, S, Trizio, S, Mercuri, N B, Teule, M A, Centonze, D, Gozzi, A, Blasi, G, Bertolino, A, Usiello, A

“…D-aspartate (D-Asp) is an atypical amino acid, which is especially abundant in the developing mammalian brain, and can bind to and activate…”
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Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum by De Chiara, Valentina, Angelucci, Francesco, Rossi, Silvia, Musella, Alessandra, Cavasinni, Francesca, Cantarella, Cristina, Mataluni, Giorgia, Sacchetti, Lucia, Napolitano, Francesco, Castelli, Maura, Caltagirone, Carlo, Bernardi, Giorgio, Maccarrone, Mauro, Usiello, Alessandro, Centonze, Diego

“…The role of brain-derived neurotrophic factor (BDNF) in emotional processes suggests an interaction with the endocannabinoid system. Here, we addressed the…”
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Vitamin A deficiency induces motor impairments and striatal cholinergic dysfunction in rats by Carta, M., Stancampiano, R., Tronci, E., Collu, M., Usiello, A., Morelli, M., Fadda, F.

“…Vitamin A and its derivatives, retinoids, are involved in the regulation of gene expression by binding two nuclear receptor families, retinoic acid receptors…”
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Dysfunctional dopaminergic neurotransmission in asocial BTBR mice by Squillace, M, Dodero, L, Federici, M, Migliarini, S, Errico, F, Napolitano, F, Krashia, P, Di Maio, A, Galbusera, A, Bifone, A, Scattoni, M L, Pasqualetti, M, Mercuri, N B, Usiello, A, Gozzi, A

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Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum by Centonze, D., Gubellini, P., Usiello, A., Rossi, S., Tscherter, A., Bracci, E., Erbs, E., Tognazzi, N., Bernardi, G., Pisani, A., Calabresi, P., Borrelli, E.

“…Compelling evidence indicates that the long (D2L) and the short (D2S) isoform of dopamine (DA) D2 receptors serve distinct physiological functions in vivo. To…”
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Rasd2 Modulates Psychotomimetic Drug Effects in Mice and Schizophrenia-related Phenotypes in Humans by Vitucci, D, Di Giorgio, A, Napolitano, F, Pelosi, B, Blasi, G, Errico, F, Attrotto, M.T, Gelao, B, Fazio, L, Taurisano, P, Di Maio, A, Marsili, V, Pasqualetti, M, Bertolino, A, Usiello, A

“…Background Rasd2 is a striatal GTP-binding protein that modulates Akt and mTOR signaling cascades, well known to be highly vulnerable pathways in psychiatric…”
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A Role for D-aspartate Oxidase in Schizophrenia and in Schizophrenia-related Symptoms Induced by Phencyclidine in Mice by Squillace, M, Errico, F, D'Argenio, V, Sforazzini, F, Iasevoli, F, Guerri, G, Napolitano, F, Angrisano, T, Di Maio, A, Vitucci, D, Bifone, A, Chiariotti, L, Bertolino, A, De Bartolomeis, A, Salvatore, F, Gozzi, A, Usiello, A

“…Introduction D-aspartate (D-Asp) is an atypical amino acid that binds to and activates NMDARs. D-Asp occurs abundantly in the embryonic brain of mammals and…”
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N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes by ADRIANI, W, FELICI, A, SARGOLINI, F, ROULLET, P, USIELLO, A, OLIVERIO, A, MELE, A

“…In this study we report on the effects of N-methyl-D-aspartate (NMDA)- and dopamine (DA)-receptor manipulation on the modulation of one-trial inhibitory…”
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D-Aspartate Prevents Corticostriatal Long-Term Depression and Attenuates Schizophrenia-Like Symptoms Induced by Amphetamine and MK-801 by Errico, Francesco, Rossi, Silvia, Napolitano, Francesco, Catuogno, Valeria, Topo, Enza, Fisone, Gilberto, D'Aniello, Antimo, Centonze, Diego, Usiello, Alessandro

“…Since their discovery in the mammalian CNS, D-aspartate and D-serine have aroused a strong interest with regard to their role as putative neuromodulatory…”
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Histone H3 Phosphorylation is Under the Opposite Tonic Control of Dopamine D2 and Adenosine A2A Receptors in Striatopallidal Neurons by BERTRAN-GONZALEZ, Jesus, HAKANSSON, Kerstin, FISONE, Gilberto, BORGKVIST, Anders, IRINOPOULOU, Theano, BRAMI-CHERRIER, Karen, USIELLO, Alessandro, GREENGARD, Paul, HERVE, Denis, GIRAULT, Jean-Antoine, VALJENT, Emmanuel

“…The antipsychotic agent haloperidol regulates gene transcription in striatal medium spiny neurons (MSNs) by blocking dopamine D2 receptors (D2Rs). We examined…”
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The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation by Gabanella, Francesca, Carissimi, Claudia, Usiello, Alessandro, Pellizzoni, Livio

“…Spinal muscular atrophy (SMA) is a lethal neuromuscular disease caused by reduced levels of expression of the survival motor neuron (SMN) protein. SMN is part…”
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