Search Results - "Ushijima, Toshikazu"

Detection and interpretation of altered methylation patterns in cancer cells by Ushijima, Toshikazu

“…Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types. New techniques have been developed to perform…”
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Accumulation of genetic and epigenetic alterations in normal cells and cancer risk by Takeshima, Hideyuki, Ushijima, Toshikazu

“…Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic alterations are induced by aging, mutagenic chemicals, ultraviolet…”
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Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation by Chiba, Tsutomu, Marusawa, Hiroyuki, Ushijima, Toshikazu

“…Chronic inflammation, regardless of infectious agents, plays important roles in the development of various cancers, particularly in digestive organs, including…”
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How to stomach an epigenetic insult: the gastric cancer epigenome by Padmanabhan, Nisha, Ushijima, Toshikazu, Tan, Patrick

“…Key Points Epigenetic alterations are pervasive in gastric malignancies Tumour epigenetic changes are multifaceted, comprising several mechanisms including…”
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Epigenetic impact of infection on carcinogenesis: mechanisms and applications by Hattori, Naoko, Ushijima, Toshikazu

“…Viral and bacterial infections are involved in the development of human cancers, such as liver, nasopharyngeal, cervical, head and neck, and gastric cancers…”
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Mapping genomic and epigenomic evolution in cancer ecosystems by Ushijima, Toshikazu, Clark, Susan J, Tan, Patrick

“…Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data…”
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Molecular Pathways: Involvement of Helicobacter pylori―Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers by USHIJIMA, Toshikazu, HATTORI, Naoko

“…Infection-associated cancers account for a large proportion of human cancers, and gastric cancer, the vast majority of which is associated with Helicobacter…”
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Compendium of aberrant DNA methylation and histone modifications in cancer by Hattori, Naoko, Ushijima, Toshikazu

“…•Aberrant epigenetic alterations are involved in cancer development and progression.•Drugs targeting epigenetic regulators and readers have been developed.•DNA…”
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Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway by Maeda, Masahiro, Moro, Hiroshi, Ushijima, Toshikazu

“…Multiple pathogenic mechanisms by which Helicobacter pylori infection induces gastric cancer have been established in the last two decades. In particular,…”
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Aberrant DNA methylation in contrast with mutations by Ushijima, Toshikazu, Asada, Kiyoshi

“…Aberrant DNA methylation is known as an important cause of human cancers, along with mutations. Although aberrant methylation was initially speculated to be…”
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Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways by Moro, Hiroshi, Hattori, Naoko, Nakamura, Yoshiaki, Kimura, Kana, Imai, Toshio, Maeda, Masahiro, Yashiro, Masakazu, Ushijima, Toshikazu

“…Background Gastric cancer is heavily influenced by aberrant DNA methylation that alters multiple cancer-related pathways, and may respond to DNA demethylating…”
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Clinicopathological and molecular correlations in traditional serrated adenoma by Sekine, Shigeki, Yamashita, Satoshi, Yamada, Masayoshi, Hashimoto, Taiki, Ogawa, Reiko, Yoshida, Hiroshi, Taniguchi, Hirokazu, Kojima, Motohiro, Ushijima, Toshikazu, Saito, Yutaka

“…Background Traditional serrated adenoma (TSA) is the least common type of colorectal serrated polyp, which exhibits considerable morphological and molecular…”
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Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy by Takeshima, Hideyuki, Wakabayashi, Mika, Hattori, Naoko, Yamashita, Satoshi, Ushijima, Toshikazu

“…Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same…”
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Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3 by Maeda, Masahiro, Takeshima, Hideyuki, Iida, Naoko, Hattori, Naoko, Yamashita, Satoshi, Moro, Hiroshi, Yasukawa, Yoshimi, Nishiyama, Kazuhiro, Hashimoto, Taiki, Sekine, Shigeki, Ishii, Genichiro, Ochiai, Atsushi, Fukagawa, Takeo, Katai, Hitoshi, Sakai, Yoshiharu, Ushijima, Toshikazu

“…Cancer-associated fibroblasts (CAFs), a major component of cancer stroma, can confer aggressive properties to cancer cells by secreting multiple factors. Their…”
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Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells by NIWA, Tohru, TSUKAMOTO, Tetsuya, TOYODA, Takeshi, MORI, Akiko, TANAKA, Harunari, MAEKITA, Takao, ICHINOSE, Masao, TATEMATSU, Masae, USHIJIMA, Toshikazu

“…Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer…”
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Methylation silencing of ULK2 via epithelial–mesenchymal transition causes transformation to poorly differentiated gastric cancers by Motoo, Iori, Nanjo, Sohachi, Ando, Takayuki, Yamashita, Satoshi, Ushijima, Toshikazu, Yasuda, Ichiro

“…Background Diffuse-type gastric cancers (DGC) typically have a poor prognosis related to their invasion and metastasis, in which the epithelial–mesenchymal…”
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TET repression and increased DNMT activity synergistically induce aberrant DNA methylation by Takeshima, Hideyuki, Niwa, Tohru, Yamashita, Satoshi, Takamura-Enya, Takeji, Iida, Naoko, Wakabayashi, Mika, Nanjo, Sohachi, Abe, Masanobu, Sugiyama, Toshiro, Kim, Young-Joon, Ushijima, Toshikazu

“…Chronic inflammation is deeply involved in various human disorders, such as cancer, neurodegenerative disorders, and metabolic disorders. Induction of…”
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Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model by Hattori, Naoko, Niwa, Tohru, Ishida, Tatsuya, Kobayashi, Kyosuke, Imai, Toshio, Mori, Akiko, Kimura, Kana, Mori, Takeshi, Asami, Yukio, Ushijima, Toshikazu

“…Chronic inflammation is involved in the development of colon cancer by inducing mutations and aberrant DNA methylation in colon epithelial cells. Furthermore,…”
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SARS-CoV-2 Antibody Response to Symptoms Indicative of COVID-19 in a Non-Infected Population in Japan: a Cross-Sectional Study by Tanaka, Shiori, Umezawa, Jun, Yamaji, Taiki, Abe, Sarah K., Hamada, Akinobu, Kobayashi, Osamu, Ushijima, Toshikazu, Inoue, Manami

“…This study was aimed at investigating differences in antibody titers indicative of the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming by Hattori, Naoko, Asada, Kiyoshi, Miyajima, Nozomu, Mori, Akiko, Nakanishi, Yoko, Kimura, Kana, Wakabayashi, Mika, Takeshima, Hideyuki, Nitani, Chika, Hara, Junichi, Ushijima, Toshikazu

“…Background The CpG island methylator phenotype of neuroblastoma (NBL) is strongly associated with poor prognosis and can be targeted by 5-aza-2’-deoxycytidine…”
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