Search Results - "Ushijima, T"

Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas by Nakamura, T., Tateishi, K., Niwa, T., Matsushita, Y., Tamura, K., Kinoshita, M., Tanaka, K., Fukushima, S., Takami, H., Arita, H., Kubo, A., Shuto, T., Ohno, M., Miyakita, Y., Kocialkowski, S., Sasayama, T., Hashimoto, N., Maehara, T., Shibui, S., Ushijima, T., Kawahara, N., Narita, Y., Ichimura, K.

“…Aims Primary central nervous system lymphoma (PCNSL) manifest aggressive clinical behaviour and have poor prognosis. Although constitutive activation of the…”
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Constructing robust and efficient experimental designs in groundwater modeling using a Galerkin method, proper orthogonal decomposition, and metaheuristic algorithms by Ushijima, Timothy T, Yeh, William W. G, Wong, Weng Kee

“…Estimating parameters accurately in groundwater models for aquifers is challenging because the models are non-explicit solutions of complex partial…”
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Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells by Kong, D, Piao, Y-S, Yamashita, S, Oshima, H, Oguma, K, Fushida, S, Fujimura, T, Minamoto, T, Seno, H, Yamada, Y, Satou, K, Ushijima, T, Ishikawa, T-O, Oshima, M

“…Inflammation has an important role in cancer development through various mechanisms. It has been shown that dysregulation of microRNAs (miRNAs) that function…”
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Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer by Kuboki, Y., Yamashita, S., Niwa, T., Ushijima, T., Nagatsuma, A., Kuwata, T., Yoshino, T., Doi, T., Ochiai, A., Ohtsu, A.

“…In advanced gastric cancer (AGC), most clinical trials are designed on the basis of protein expression or gene amplification of specific genes. Recently,…”
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Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer by West, A C, Tang, K, Tye, H, Yu, L, Deng, N, Najdovska, M, Lin, S J, Balic, J J, Okochi-Takada, E, McGuirk, P, Keogh, B, McCormack, W, Bhathal, P S, Reilly, M, Oshima, M, Ushijima, T, Tan, P, Jenkins, B J

“…Toll-like receptors (TLRs) are key regulators of innate immune responses, and their dysregulation is observed in numerous inflammation-associated malignancies,…”
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ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis by Okochi-Takada, E, Hattori, N, Tsukamoto, T, Miyamoto, K, Ando, T, Ito, S, Yamamura, Y, Wakabayashi, M, Nobeyama, Y, Ushijima, T

“…Tumor suppressors with extracellular function are likely to have advantages as targets for cancer therapy, but few are known. Here, we focused on…”
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An attempt to improve accuracy of higher-order statistics and spectra in direct numerical simulation of incompressible wall turbulence by using the compact schemes for viscous terms by Suzuki, H., Nagata, K., Sakai, Y., Hayase, T., Hasegawa, Y., Ushijima, T.

“…SUMMARYWe attempt to improve accuracy in the high‐wavenumber region in DNS of incompressible wall turbulence such as found in fully developed turbulent channel…”
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FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect by Asada, K, Ando, T, Niwa, T, Nanjo, S, Watanabe, N, Okochi-Takada, E, Yoshida, T, Miyamoto, K, Enomoto, S, Ichinose, M, Tsukamoto, T, Ito, S, Tatematsu, M, Sugiyama, T, Ushijima, T

“…Tumor-suppressor genes on chromosome X can be inactivated by a single hit, any of the point mutations, chromosomal loss and aberrant DNA methylation. As…”
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Dual inhibition of BET and mutant BRAF in BRAF-mutant colon cancer cells suppresses oncogenic pathways and synergistically inhibits their growth by Nakamura, Y, Hattori, N, Iida, N, Yoshino, T, Ushijima, T

“…Bromodomain and extra-terminal (BET) inhibitors show strong cytotoxicity against several tumors by disrupting super-enhancers, defined as a large cluster of…”
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Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction by Katsurano, M, Niwa, T, Yasui, Y, Shigematsu, Y, Yamashita, S, Takeshima, H, Lee, M S, Kim, Y-J, Tanaka, T, Ushijima, T

“…Epigenetic fields for cancerization are involved in development of human cancers, especially those associated with inflammation and multiple occurrences…”
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Genome-wide profiling of promoter methylation in human by HATADA, I, FUKASAWA, M, KONDO, T, HORII, A, USHIJIMA, T, SASAKI, H, KIMURA, M, MORITA, S, YAMADA, K, YOSHIKAWA, T, YAMANAKA, S, ENDO, C, SAKURADA, A, SATO, M

“…DNA methylation in the promoter region of a gene is associated with a loss of that gene's expression and plays an important role in gene silencing. The…”
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Development of novel DNA demethylating agents with greater stability and less toxicity by Hattori, N, Sako, M, Kimura, K, Mori, A, Okochi-Takada, E, Tonomura, H, Ushijima, T

“…Applications of epigenelic therapy are expanding from hematological to solid tumors. However, two approved DNA demethylating agents, 5-azacytidine (5-Aza,…”
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Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes by Tsukamoto, T, Mizoshita, T, Mihara, M, Tanaka, H, Takenaka, Y, Yamamura, Y, Nakamura, S, Ushijima, T, Tatematsu, M

“…Aims:  Other than ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, the molecular mechanisms underlying gastric and intestinal phenotypes…”
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403 EVALUATION OF CARTILAGE DEGRADATION IN ARTHRITIS USING Tip MAGNETIC RESONANCE IMAGING MAPPING by Okazaki, K, Tsushima, H, Ushijima, T, Iwamoto, Y

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717 Combined Exposure to Multiple Carcinogens Enhances Development of Rat Mammary Cancers With Characteristic Gene Expression by Imaoka, T, Nishimura, M, Ishikawa, K, Yamashita, S, Ohmachi, Y, Suzuki, H, Daino, K, Ushijima, T, Imai, T, Shimada, Y

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Decreased fidelity in replicating CpG methylation patterns in cancer cells by USHIJIMA, Toshikazu, WATANABE, Naoko, SHIMIZU, Kimiko, MIYAMOTO, Kazuaki, SUGIMURA, Takashi, KANEDA, Atsushi

“…The unmethylated or methylated status of individual CpG sites is faithfully copied into daughter cells. Here, we analyzed the fidelity in replicating their…”
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Characterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis by Matsuda, H, Fujiyama, Y, Andoh, A, Ushijima, T, Kajinami, T, Bamba, T

“…Background : Previous reports on faecal microflora have demonstrated that the total number of aerobes and coliforms was increased in patients with ulcerative…”
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Surgical treatment of bilateral coronary-to-pulmonary artery fistulas by Yamamoto, Yoshitaka, Ushijima, Teruaki, Takata, Munehisa, Watanabe, Go

“…Bilateral coronary artery fistulas with the coronary artery stenosis are rare. In this case, we successfully performed closure of coronary artery fistulas with…”
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Experimental design for estimating unknown hydraulic conductivity in an aquifer using a genetic algorithm and reduced order model by Ushijima, Timothy T., Yeh, William W-G.

“…•We developed an algorithm for robust experimental design.•We use a genetic algorithm to solve a max–min optimization problem.•We use model order reduction to…”
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Applying whole-genome studies of epigenetic regulation to study human disease by Lieb, J D, Beck, S, Bulyk, M L, Farnham, P, Hattori, N, Henikoff, S, Liu, X S, Okumura, K, Shiota, K, Ushijima, T, Greally, J M

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