Search Results - "Ushigome, Fumihiko"

Effects of grapefruit juice and orange juice components on P‐glycoprotein‐ and MRP2‐mediated drug efflux by Honda, Yoko, Ushigome, Fumihiko, Koyabu, Noriko, Morimoto, Satoshi, Shoyama, Yukihiro, Uchiumi, Takeshi, Kuwano, Michihiko, Ohtani, Hisakazu, Sawada, Yasufumi

“…We investigated the effects of grapefruit juice (GFJ) and orange juice (OJ) on drug transport by MDR1 P‐glycoprotein (P‐gp) and multidrug resistance protein 2…”
Get full text

Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein by Ushigome, Fumihiko, Takanaga, Hitomi, Matsuo, Hirotami, Yanai, Shigeaki, Tsukimori, Kiyomi, Nakano, Hitoo, Uchiumi, Takeshi, Nakamura, Takanori, Kuwano, Michihiko, Ohtani, Hisakazu, Sawada, Yasufumi

“…To elucidate the role of P-glycoprotein in human placenta, we examined its expression in placenta, and the transcellular transport and uptake of P-glycoprotein…”
Get full text

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells by Ikegawa, Tomomi, Ushigome, Fumihiko, Koyabu, Noriko, Morimoto, Satoshi, Shoyama, Yukihiro, Naito, Mikihiko, Tsuruo, Takashi, Ohtani, Hisakazu, Sawada, Yasufumi

“…We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of […”
Get full text

Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4 by Yamashita, Fumiaki, Ohtani, Hisakazu, Koyabu, Noriko, Ushigome, Fumihiko, Satoh, Hiroki, Murakami, Hideyasu, Uchiumi, Takeshi, Nakamura, Takanori, Kuwano, Michihiko, Tsujimoto, Masayuki, Sawada, Yasufumi

“…Human organic anion transporter 4 (OAT4) is the only member of the OAT family that is expressed in the placenta and also expressed in kidney. Although OAT4 has…”
Get full text

H(+)-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo by Emoto, Akiko, Ushigome, Fumihiko, Koyabu, Noriko, Kajiya, Hiroshi, Okabe, Koji, Satoh, Shoji, Tsukimori, Kiyomi, Nakano, Hitoo, Ohtani, Hisakazu, Sawada, Yasufumi

“…We investigated the transport of salicylic acid and L-lactic acid across the placenta using the human trophoblast cell line BeWo. We performed uptake…”
Get more information

Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates by Otsuka, Yukio, Poondru, Srinivasu, Bonate, Peter L., Rose, Rachel H., Jamei, Masoud, Ushigome, Fumihiko, Minematsu, Tsuyoshi

“…Enzalutamide is known to strongly induce cytochrome P450 3A4 (CYP3A4). Furthermore, enzalutamide showed induction and inhibition of P-glycoprotein (P-gp) in in…”
Get full text

Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo) by Ushigome, Fumihiko, Takanaga, Hitomi, Matsuo, Hirotami, Tsukimori, Kiyomi, Nakano, Hitoo, Ohtani, Hisakazu, Sawada, Yasufumi

“…Valproic acid is an anticonvulsant widely used for the treatment of epilepsy. However, valproic acid is known to show fetal toxicity, including teratogenicity…”
Get full text

The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function by Shimamura, Masahiro, Miyakawa, Jun, Doi, Masaaki, Okada, Kiyonobu, Kurumatani, Hajimu, Mori, Yoshitaka, Oshida, Keiyu, Nakajo, Ikumi, Oikawa, Keishi, Ushigome, Fumihiko, Miyashita, Aiji, Isono, Masanao, Miyamoto, Yohei

“…The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS‐314d, in Japanese subjects with…”
Get full text

Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β3‑Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems by Takusagawa, Shin, Ushigome, Fumihiko, Nemoto, Hiroyuki, Takahashi, Yutaka, Li, Qun, Kerbusch, Virginie, Miyashita, Aiji, Iwatsubo, Takafumi, Usui, Takashi

“…Mirabegron, a weak-basic compound, is a potent and selective β3-adrenoceptor agonist for the treatment of overactive bladder. Mirabegron extended release…”
Get full text

Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β 3 -Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems by Takusagawa, Shin, Ushigome, Fumihiko, Nemoto, Hiroyuki, Takahashi, Yutaka, Li, Qun, Kerbusch, Virginie, Miyashita, Aiji, Iwatsubo, Takafumi, Usui, Takashi

Get full text

The Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Ipragliflozin, a Novel Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor by Zhang, Wenhui, Krauwinkel, Walter J. J., Keirns, James, Townsend, Robert W., Lasseter, Kenneth C., Plumb, Lisa, Kadokura, Takeshi, Ushigome, Fumihiko, Smulders, Ronald

“…Background Ipragliflozin (ASP1941), a potent selective sodium glucose co-transporter 2 inhibitor, is in development for the treatment of type 2 diabetes…”
Get full text

Kinetic analysis of P-glycoprotein-mediated transport by using normal human placental brush-border membrane vesicles by USHIGOME, Fumihiko, KOYABU, Noriko, SATOH, Shoji, TSUKIMORI, Kiyomi, NAKANO, Hitoo, NAKAMURA, Takanori, UCHIUMI, Takeshi, KUWANO, Michihiko, OHTANI, Hisakazu, SAWADA, Yasufumi

“…P-Glycoprotein (Pgp) plays an important role in drug disposition and excretion in various tissues such as the brain, intestine, and kidney. Moreover, we have…”
Get full text

Characteristics of L-lactic acid transport in basal membrane vesicles of human placental syncytiotrophoblast by Inuyama, Masako, Ushigome, Fumihiko, Emoto, Akiko, Koyabu, Noriko, Satoh, Shoji, Tsukimori, Kiyomi, Nakano, Hitoo, Ohtani, Hisakazu, Sawada, Yasufumi

“…The characteristics of L-lactic acid transport across the trophoblast basal membrane were investigated and compared with those across the brush-border membrane…”
Get more information

Proton gradient-dependent transport of valproic acid in human placental brush-border membrane vesicles by NAKAMURA, Hiroaki, USHIGOME, Fumihiko, KOYABU, Noriko, SATOH, Shoji, TSUKIMORI, Kiyomi, NAKANO, Hitoo, OHTANI, Hisakazu, SAWADA, Yasufumi

“…To investigate the transport mechanism of valproic acid across the human placenta, we used human placental brush-border membrane vesicles and compared them…”
Get full text

Transport mechanism of organic anion drug across the blood-placental barrier by Ushigome, Fumihiko, Nakamura, Hiroaki, Emoto, Akiko, Inuyama, Masako, Takanaga, Hitomi, Matsuo, Hirotami, Komatsu, Hajime, Yanai, Shigeaki, Tsukimori, Kiyomi, Nakano, Hitoo, Sawada, Yasufumi

Get full text