Search Results - "Usenovic, Marija"

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells by Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E, Yao, Lihang, Gaspar, Renee C, Hatcher, Nathan G, Schachter, Joel, Renger, John J, Parmentier-Batteur, Sophie

“…Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological hallmark of several neurodegenerative tauopathies, including…”
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Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models by Jablonski, Angela Marie, Warren, Lee, Usenovic, Marija, Zhou, Heather, Sugam, Jonathan, Parmentier-Batteur, Sophie, Voleti, Bhavya

“…ApoEε4 is a major genetic risk factor for Alzheimer’s disease (AD), a disease hallmarked by extracellular amyloid-beta (Aβ) plaques and intracellular…”
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Lysosomal dysfunction in neurodegeneration: The role of ATP13A2/PARK9 by Usenovic, Marija, Krainc, Dimitri

“…Neuronal homeostasis and survival critically depend on an efficient autophagy-lysosomal degradation pathway, especially since neurons cannot reduce the…”
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Analysis of blood-based gene expression in idiopathic Parkinson disease by Shamir, Ron, Amar, David

“…OBJECTIVE:To examine whether gene expression analysis of a large-scale Parkinson disease (PD) patient cohort produces a robust blood-based PD gene signature…”
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Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity by Usenovic, Marija, Tresse, Emilie, Mazzulli, Joseph R, Taylor, J Paul, Krainc, Dimitri

“…The autophagy-lysosomal pathway plays an important role in the clearance of long-lived proteins and dysfunctional organelles. Lysosomal dysfunction has been…”
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NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS by Usenovic, Marija, Suon, Sokreine, Gretzula, Cheryl Anne, Parmentier-Batteur, Sophie

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P3‐192: NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS by Usenovic, Marija, Suon, Sokreine, Gretzula, Cheryl Anne, Parmentier-Batteur, Sophie

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PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy by Berdichevsky, Yevgeny, Dryer, Alexandra M, Saponjian, Yero, Mahoney, Mark M, Pimentel, Corrin A, Lucini, Corrina A, Usenovic, Marija, Staley, Kevin J

“…mTOR is activated in epilepsy, but the mechanisms of mTOR activation in post-traumatic epileptogenesis are unknown. It is also not clear whether mTOR…”
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Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity by USENOVIC, Marija, KNIGHT, Adam L, RAY, Arpita, WONG, Victoria, BROWN, Kevin R, CALDWELL, Guy A, CALDWELL, Kim A, STAGLJAR, Igor, KRAINC, Dimitri

“…Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and dysfunctional organelles…”
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P3‐006: Models of tau pathology in induced pluripotent stem cell‐derived human neurons by Usenovic, Marija, Niroomand, Shahriar, Schachter, Joel, Zhou, Heather, Renger, John J., Parmentier-Batteur, Sophie

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PHENOTYPIC SCREENING FOR NOVEL INHIBITORS OF TAU AGGREGATION IN HUMAN IPSC-DERIVED NEURONS by Voleti, Bhavya, Warren, Lee, Usenovic, Marija, Schachter, Joel B., Zhou, Heather, Walji, Abbas, Luo, Bin, Li, Jing, Parmentier-Batteur, Sophie

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Models of tau pathology in induced pluripotent stem cell-derived human neurons by Usenovic, Marija, Niroomand, Shahriar, Schachter, Joel, Zhou, Heather, Renger, John J, Parmentier-Batteur, Sophie

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Identification of novel ATP13A2 interactors and their role in [alpha]-synuclein misfolding and toxicity by Usenovic, Marija, Knight, Adam L, Ray, Arpita, Wong, Victoria, Brown, Kevin R, Caldwell, Guy A, Caldwell, Kim A, Stagljar, Igor, Krainc, Dimitri

“…Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and dysfunctional organelles…”
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