Search Results - "Usanov, Dmitry L"

Reductive Amination in the Synthesis of Pharmaceuticals by Afanasyev, Oleg I, Kuchuk, Ekaterina, Usanov, Dmitry L, Chusov, Denis

“…Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among…”
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Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules by Usanov, Dmitry L., Chan, Alix I., Maianti, Juan Pablo, Liu, David R.

“…DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with…”
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In an Attempt to Provide a User's Guide to the Galaxy of Benzylidene, Alkoxybenzylidene, and Indenylidene Ruthenium Olefin Metathesis Catalysts by Bieniek, Michał, Michrowska, Anna, Usanov, Dmitry L., Grela, Karol

“…The data reported in this paper demonstrate that great care must be taken when choosing an appropriate catalyst for a given metathesis reaction…”
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Asymmetric Nozaki-Hiyama Propargylation of Aldehydes: Enhancement of Enantioselectivity by Cobalt Co‐Catalysis by Usanov, Dmitry L, Yamamoto, Hisashi

“…It takes two to tango! A combination of partially reduced chiral H8‐TBOx chromium catalyst 1 and achiral cobalt porphine co‐catalyst 2 (Ar=p‐anisyl) led to an…”
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Dichotomy of Atom-Economical Hydrogen-Free Reductive Amidation vs Exhaustive Reductive Amination by Kolesnikov, Pavel N, Usanov, Dmitry L, Muratov, Karim M, Chusov, Denis

“…Rh-catalyzed one-step reductive amidation of aldehydes has been developed. The protocol does not require an external hydrogen source and employs carbon…”
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Lewis Acid Catalyzed Asymmetric Cyanohydrin Synthesis by North, Michael, Usanov, Dmitry L, Young, Carl

“…The catalytic synthesis of asymmetric cyanohydrin by Lewis acids is discussed. Emphasis is on the chemical reactions which form the fundamental carbon bond…”
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Reductive Transformations of Carbonyl Compounds Catalyzed by Rhodium Supported on a Carbon Matrix by using Carbon Monoxide as a Deoxygenative Agent by Yagafarov, Niyaz Z., Usanov, Dmitry L., Moskovets, Alexey P., Kagramanov, Nikolai D., Maleev, Victor I., Chusov, Denis

“…An efficient method for the rhodium on carbon matrix catalyzed preparation of secondary and tertiary amines, cyanoesters, and nitriles through the reductive…”
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Mechanism‐Guided Development of VO(salen)X Complexes as Catalysts for the Asymmetric Synthesis of Cyanohydrin Trimethylsilyl Ethers by Belokon, Yuri N., Clegg, William, Harrington, Ross W., Maleev, Victor I., North, Michael, Pujol, Marta Omedes, Usanov, Dmitry L., Young, Carl

“…Catalyze this! Detailed study of the mechanism of asymmetric cyanohydrin synthesis catalyzed by VO(salen)X complexes (see figure) led to the development of…”
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Gold(I)-Catalyzed Cyclodehydration Enabled by the Triisopropylsilyl Group: A Synthetically Versatile Methodology by Usanov, Dmitry L., Naodovic, Marina, Brasholz, Malte, Yamamoto, Hisashi

“…Introduction of a triisopropylsilyl group into allyl and allenyl carbinols greatly enhances the efficiency of gold(I)‐catalyzed cyclodehydration, which can…”
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Enantioselective Alkynylation of Aldehydes with 1-Haloalkynes Catalyzed by Tethered Bis(8-quinolinato) Chromium Complex by Usanov, Dmitry L, Yamamoto, Hisashi

“…The first example of Cr-catalyzed asymmetric alkynylation of aldehydes with 1-iodo- and 1-bromoalkynes was developed. The use of tethered bis(8-quinolinato)…”
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Formation of Five- and Seven-Membered Rings Enabled by the Triisopropylsilyl Auxiliary Group by Usanov, Dmitry L, Yamamoto, Hisashi

“…A highly convenient synthetic pathway to 2-indanones from aldehydes was established. The introduction of a triisopropylsilyl group greatly facilitated Meinwald…”
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Atom- and Step-Economical Ruthenium-Catalyzed Synthesis of Esters from Aldehydes or Ketones and Carboxylic Acids by Runikhina, Sofiya A, Usanov, Dmitry L, Chizhov, Alexander O, Chusov, Denis

“…We developed a ruthenium-catalyzed reductive ester synthesis from aldehydes or ketones and carboxylic acids using carbon monoxide as a deoxygenative agent…”
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Discovery and molecular basis of subtype-selective cyclophilin inhibitors by Peterson, Alexander A., Rangwala, Aziz M., Thakur, Manish K., Ward, Patrick S., Hung, Christie, Outhwaite, Ian R., Chan, Alix I., Usanov, Dmitry L., Mootha, Vamsi K., Seeliger, Markus A., Liu, David R.

“…Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described…”
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Ruthenium-Catalyzed Reductive Amination without an External Hydrogen Source by Kolesnikov, Pavel N, Yagafarov, Niyaz Z, Usanov, Dmitry L, Maleev, Victor I, Chusov, Denis

“…A ruthenium-catalyzed reductive amination without an external hydrogen source has been developed using carbon monoxide as the reductant and ruthenium(III)…”
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Dichotomy of Reductive Addition of Amines to Cyclopropyl Ketones vs Pyrrolidine Synthesis by Afanasyev, Oleg I, Tsygankov, Alexey A, Usanov, Dmitry L, Chusov, Denis

“…An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive…”
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Author Correction: Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules by Usanov, Dmitry L., Chan, Alix I., Maianti, Juan Pablo, Liu, David R.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The synthesis of sterically hindered amines by a direct reductive amination of ketones by Yagafarov, Niyaz Z, Kolesnikov, Pavel N, Usanov, Dmitry L, Novikov, Valentin V, Nelyubina, Yulia V, Chusov, Denis

“…An atom-economical methodology for the synthesis of sterically hindered tertiary amines was developed, which is based on complementary Rh- and Ru-catalyzed…”
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Cyclobutadiene Metal Complexes: A New Class of Highly Selective Catalysts. An Application to Direct Reductive Amination by Afanasyev, Oleg I, Tsygankov, Alexey A, Usanov, Dmitry L, Perekalin, Dmitry S, Shvydkiy, Nikita V, Maleev, Victor I, Kudinov, Alexander R, Chusov, Denis

“…A catalyst of a new type, cyclobutadiene complex [(C4Et4)­Rh­(p-xylene)]­PF6, was found to promote selective reductive amination in the presence of carbon…”
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Multimodal small-molecule screening for human prion protein binders by Reidenbach, Andrew G., Mesleh, Michael F., Casalena, Dominick, Vallabh, Sonia M., Dahlin, Jayme L., Leed, Alison J., Chan, Alix I., Usanov, Dmitry L., Yehl, Jenna B., Lemke, Christopher T., Campbell, Arthur J., Shah, Rishi N., Shrestha, Om K., Sacher, Joshua R., Rangel, Victor L., Moroco, Jamie A., Sathappa, Murugappan, Nonato, Maria Cristina, Nguyen, Kong T., Wright, S. Kirk, Liu, David R., Wagner, Florence F., Kaushik, Virendar K., Auld, Douglas S., Schreiber, Stuart L., Minikel, Eric Vallabh

“…Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no…”
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Ruthenium‐Catalyzed Reductive Amidation without an External Hydrogen Source by Yagafarov, Niyaz Z., Muratov, Karim M., Biriukov, Klim, Usanov, Dmitry L., Chusova, Olga, Perekalin, Dmitry S., Chusov, Denis

“…A catalytic reaction between aldehydes and primary amides that leads to N‐alkylated amides was investigated. The developed protocol employs carbon monoxide as…”
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