Search Results - "Urrutia, Janire"

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade by Revuelta, Miren, Urrutia, Janire, Villarroel, Alvaro, Casis, Oscar

“…Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during Alzheimer’s Disease (AD) due to the imbalance in the production vs…”
Get full text

The Crossroad of Ion Channels and Calmodulin in Disease by Urrutia, Janire, Aguado, Alejandra, Muguruza-Montero, Arantza, Núñez, Eider, Malo, Covadonga, Casis, Oscar, Villarroel, Alvaro

“…Calmodulin (CaM) is the principal Ca sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the…”
Get full text

Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases by Urrutia, Janire, Arrizabalaga-Iriondo, Ane, Sanchez-Del-Rey, Ana, Martinez-Ibargüen, Agustín, Gallego, Mónica, Casis, Oscar, Revuelta, Miren

“…Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca flow through the…”
Get full text

Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr by Doss, Michael Xavier, Di Diego, José M., Goodrow, Robert J., Wu, Yuesheng, Cordeiro, Jonathan M., Nesterenko, Vladislav V., Barajas-Martínez, Héctor, Hu, Dan, Urrutia, Janire, Desai, Mayurika, Treat, Jacqueline A., Sachinidis, Agapios, Antzelevitch, Charles

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) hold promise for therapeutic applications. To serve these functions, the hiPSC-CM must…”
Get full text

Redox regulation of KV7 channels through EF3 hand of calmodulin by Nuñez, Eider, Jones, Frederick, Muguruza-Montero, Arantza, Urrutia, Janire, Aguado, Alejandra, Malo, Covadonga, Bernardo-Seisdedos, Ganeko, Domene, Carmen, Millet, Oscar, Gamper, Nikita, Villarroel, Alvaro

“…Neuronal K V 7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the…”
Get full text

An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel by Urrutia, Janire, Aguado, Alejandra, Gomis-Perez, Carolina, Muguruza-Montero, Arantza, Ballesteros, Oscar R, Zhang, Jiaren, Nuñez, Eider, Malo, Covadonga, Chung, Hee Jung, Leonardo, Aritz, Bergara, Aitor, Villarroel, Alvaro

“…The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of…”
Get full text

CaMKII Modulates the Cardiac Transient Outward K + Current through its Association with Kv4 Channels in Non-Caveolar Membrane Rafts by Alday, Aintzane, Ahyayauch, Hasna, Fernández-López, Victor, Echeazarra, Leyre, Urrutia, Janire, Casis, Oscar, Gallego, Mónica

“…To test whether the physiological regulation of the cardiac Kv4 channels by the Ca /calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid…”
Get full text

Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8 by Barajas-Martínez, Hector, PhD, Hu, Dan, MD, PhD, Ferrer, Tania, PhD, Onetti, Carlos G., PhD, Wu, Yuesheng, MD, Burashnikov, Elena, BS, Boyle, Madalene, BS, Surman, Tyler, BS, Urrutia, Janire, PhD, Veltmann, Christian, MD, Schimpf, Rainer, MD, Borggrefe, Martin, MD, Wolpert, Christian, MD, Ibrahim, Bassiema B., MD, Sánchez-Chapula, José Antonio, MD, PhD, Winters, Stephen, MD, Haïssaguerre, Michel, MD, Antzelevitch, Charles, PhD, FHRS, AHA

“…Background Adenosine triphosphate (ATP)-sensitive potassium cardiac channels consist of inward-rectifying channel subunits Kir6.1 or Kir6.2 (encoded by KCNJ8…”
Get full text

Ionic channels underlying the ventricular action potential in zebrafish embryo by Alday, Aintzane, Alonso, Hiart, Gallego, Monica, Urrutia, Janire, Letamendia, Ainhoa, Callol, Carles, Casis, Oscar

“…Over the last years zebrafish has become a popular model in the study of cardiac physiology, pathology and pharmacology. Recently, the application of the 3Rs…”
Get full text

Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes by Urrutia, Janire, Alday, Aintzane, Gallego, Mónica, Malagueta-Vieira, L. Layse, Aréchiga-Figueroa, Ivan Arael, Casis, Oscar, Sánchez-Chapula, José Antonio

“…Background: The rapid delayed rectifier K + current (I Kr ), carried by the hERG protein, is one of the main repolarising currents in the human heart and a…”
Get full text

Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the Ito Current Density in Type 1 Diabetic Rat Cardiomyocytes by Setién, Raúl, Alday, Aintzane, Diaz-Asensio, Cristina, Urrutia, Janire, Gallego, Mónica, Casis, Oscar

“…Background/Aims: In diabetic ventricular myocytes, transient outward potassium current (I to ) amplitude is severely reduced because of the impaired…”
Get full text

Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr) by Doss, Michael Xavier, Di Diego, José M, Goodrow, Robert J, Wu, Yuesheng, Cordeiro, Jonathan M, Nesterenko, Vladislav V, Barajas-Martínez, Héctor, Hu, Dan, Urrutia, Janire, Desai, Mayurika, Treat, Jacqueline A, Sachinidis, Agapios, Antzelevitch, Charles

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) hold promise for therapeutic applications. To serve these functions, the hiPSC-CM must…”
Get full text

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents by Hu, Dan, Barajas-Martínez, Hector, Medeiros-Domingo, Argelia, Crotti, Lia, Veltmann, Christian, Schimpf, Rainer, Urrutia, Janire, Alday, Aintzane, Casis, Oscar, Pfeiffer, Ryan, Burashnikov, Elena, Caceres, Gabriel, Tester, David J, Wolpert, Christian, Borggrefe, Martin, Schwartz, Peter, Ackerman, Michael J, Antzelevitch, Charles

“…Cardiac sodium channel β-subunit mutations have been associated with several inherited cardiac arrhythmia syndromes. To identify and characterize variations in…”
Get full text

α1-Adrenoreceptors regulate only the caveolae-located subpopulation of cardiac KV4 channels by Alday, Aintzane, Urrutia, Janire, Gallego, Monica, Casis, Oscar

“…In ventricular myocytes, α1-AR stimulates Gas proteins and reduces the transient outward K + current (Ito) via a cAMP/PKA-mediated pathway and thus regulates…”
Get full text

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer's Disease: Possible Therapeutic Role of K V 1.3 Channel Blockade by Revuelta, Miren, Urrutia, Janire, Villarroel, Alvaro, Casis, Oscar

“…Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during Alzheimer's Disease (AD) due to the imbalance in the production vs…”
Get full text

Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy by Gomis‐Pérez, Carolina, Urrutia, Janire, Marcé‐Grau, Anna, Malo, Covadonga, López‐Laso, Eduardo, Felipe‐Rucián, Ana, Raspall‐Chaure, Miquel, Macaya, Alfons, Villarroel, Alvaro

“…Summary Objective To gain insight into the mechanisms underlying KCNQ2 encephalopathy by examining the electrophysiologic properties of mutant Kv7.2 channels…”
Get full text

Do calmodulin binding IQ motifs have built‐in capping domains? by Muguruza‐Montero, Arantza, Ramis, Rafael, Nuñez, Eider, R. Ballesteros, Oscar, G. Ibarluzea, Markel, Araujo, Ariane, M‐Alicante, Sara, Urrutia, Janire, Leonardo, Aritz, Bergara, Aitor, Villarroel, Alvaro

“…Most calmodulin (CaM) targets are α‐helices. It is not clear if CaM induces the adoption of an α‐helix configuration to its targets or if those targets are…”
Get full text

Homomeric Kv7.2 current suppression is a common feature in KCNQ 2 epileptic encephalopathy by Gomis‐Pérez, Carolina, Urrutia, Janire, Marcé‐Grau, Anna, Malo, Covadonga, López‐Laso, Eduardo, Felipe‐Rucián, Ana, Raspall‐Chaure, Miquel, Macaya, Alfons, Villarroel, Alvaro

Get full text

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Nav1.5 and Kv4.3 channel currents by Hu, Dan, Barajas-Martínez, Hector, Medeiros-Domingo, Argelia, Crotti, Lia, Veltmann, Christian, Schimpf, Rainer, Urrutia, Janire, Alday, Aintzane, Casis, Oscar, Pfeiffer, Ryan, Burashnikov, Elena, Caceres, Gabriel, Tester, David J., Wolpert, Christian, Borggrefe, Martin, Schwartz, Peter, Ackerman, Michael J., Antzelevitch, Charles

“…Cardiac sodium channel β-subunit mutations have been associated with several inherited cardiac arrhythmia syndromes. To identify and characterize variations in…”
Get full text

Redox regulation of K V 7 channels through EF3 hand of calmodulin by Nuñez, Eider, Jones, Frederick, Muguruza-Montero, Arantza, Urrutia, Janire, Aguado, Alejandra, Malo, Covadonga, Bernardo-Seisdedos, Ganeko, Domene, Carmen, Millet, Oscar, Gamper, Nikita, Villarroel, Alvaro

“…Neuronal K 7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the…”
Get full text