Search Results - "Urquhart, Brad"

Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning by Dorman, Stephanie N., Baranova, Katherina, Knoll, Joan H.M., Urquhart, Brad L., Mariani, Gabriella, Carcangiu, Maria Luisa, Rogan, Peter K.

“…Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been related to changes in the genomic profile of tumors. We investigated…”
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Thirty‐day risk of digoxin toxicity among older adults co‐prescribed trimethoprim‐sulfamethoxazole versus amoxicillin: A population‐based cohort study by Muanda, Flory T., Weir, Matthew A., Ahmadi, Fatemeh, McArthur, Eric, Sontrop, Jessica M., Abdullah, Sheikh S., Urquhart, Brad L., Sadeghi, Hasti, Kim, Richard B., Garg, Amit X.

“…Importance Trimethoprim‐sulfamethoxazole (TMP‐SMX) may increase digoxin concentration, a medication with a narrow therapeutic index. Small changes in digoxin…”
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Oleic Acid Counters Impaired Blastocyst Development Induced by Palmitic Acid During Mouse Preimplantation Development: Understanding Obesity-Related Declines in Fertility by Yousif, Maisoon D, Calder, Michele D, Du, Jin Tong, Ruetz, Kelsey N, Crocker, Kylie, Urquhart, Brad L, Betts, Dean H, Rafea, Basim Abu, Watson, Andrew J

“…Obesity is associated with altered fatty acid profiles, reduced fertility, and assisted reproductive technology (ART) success. The effects of palmitic acid…”
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Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice by Engineer, Anish, Saiyin, Tana, Lu, Xiangru, Kucey, Andrew S, Urquhart, Brad L, Drysdale, Thomas A, Norozi, Kambiz, Feng, Qingping

“…Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the…”
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Coffee-Antihypertensive Drug Interaction: A Hemodynamic and Pharmacokinetic Study With Felodipine by Bailey, David G, Dresser, George K, Urquhart, Brad L, Freeman, David J, Arnold, John Malcolm

“…A period of abstinence from coffee to permit caffeine elimination appears to enable increased blood pressure on subsequent exposure. We hypothesized that this…”
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Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats by Dotzert, Michelle S., Murray, Michael R., McDonald, Matthew W., Olver, T. Dylan, Velenosi, Thomas J., Hennop, Anzel, Noble, Earl G., Urquhart, Brad L., Melling, C. W. James

“…The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL)…”
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Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study by Gill, Natasha, Sirizzotti, Natalie, Johnson, David, Joubert, Gary, Kucey, Andrew S, Tieu, Alvin, Urquhart, Brad L, Columbus, Melanie, Lim, Rodrick, Rieder, Michael, Mehrotra, Shruti, Hartjes, Emily D, Poonai, Naveen

“…OBJECTIVESDexamethasone is associated with adrenal insufficiency in adults and children with chronic disease. This association has not been studied after…”
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Low-Dose Methotrexate and Serious Adverse Events Among Older Adults With Chronic Kidney Disease by Muanda, Flory T, Blake, Peter G, Weir, Matthew A, Ahmadi, Fatemeh, McArthur, Eric, Sontrop, Jessica M, Urquhart, Brad L, Kim, Richard B, Garg, Amit X

“…Low-dose methotrexate is used to treat rheumatoid arthritis and psoriasis. Due to its kidney elimination, better evidence is needed to inform its safety in…”
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Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation by Thirumaran, Ranjit K., Lamba, Jatinder K., Kim, Richard B., Urquhart, Brad L., Gregor, Jamie C., Chande, Nilesh, Fan, Yiping, Qi, An, Cheng, Cheng, Thummel, Kenneth E., Hall, Stephen D., Schuetz, Erin G.

“…Vitamin D, whose levels vary seasonally with sunlight, is activated to 1α,25-dihydroxyvitamin D3 that binds the vitamin D receptor (VDR) and transcriptionally…”
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Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation by van der Veer, Eric, Nong, Zengxuan, O’Neil, Caroline, Urquhart, Brad, Freeman, David, Pickering, J Geoffrey

“…Conversion of vascular smooth muscle cells (SMCs) from a proliferative state to a nonproliferative, contractile state confers vasomotor function to developing…”
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N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes by Moazzen, Hoda, Lu, Xiangru, Ma, Noelle L, Velenosi, Thomas J, Urquhart, Brad L, Wisse, Lambertus J, Gittenberger-de Groot, Adriana C, Feng, Qingping

“…Pregestational diabetes is a major risk factor of congenital heart defects (CHDs). Glutathione is depleted and reactive oxygen species (ROS) production is…”
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Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2) by Ho, Richard H, Leake, Brenda F, Urquhart, Brad L, Gregor, Jamie C, Dawson, Paul A, Kim, Richard B

“…Background and Aim:  The major transporter responsible for bile acid uptake from the intestinal lumen is the apical sodium‐dependent bile acid transporter…”
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The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats by Kucey, Andrew S., Velenosi, Thomas J., Tonial, Nicholas C., Tieu, Alvin, RaoPeters, Adrien A. E., Urquhart, Brad L.

“…Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function over time. CKD affects greater than 10% of the population and its…”
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Coffee inhibition of CYP3A4 in vitro was not translated to a grapefruit‐like pharmacokinetic interaction clinically by Dresser, George K., Urquhart, Brad L., Proniuk, Julianne, Tieu, Alvin, Freeman, David J., Arnold, John Malcolm, Bailey, David G.

“…Grapefruit can augment oral medication bioavailability through irreversible (mechanism‐based) inhibition of intestinal CYP3A4. Supplementary data from our…”
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The effect of chronic kidney disease on CYP 2B expression and activity in male Wistar rats by Kucey, Andrew S., Velenosi, Thomas J., Tonial, Nicholas C., Tieu, Alvin, RaoPeters, Adrien A. E., Urquhart, Brad L.

“…Abstract Chronic kidney disease ( CKD ) is characterized by progressive reduction in kidney function over time. CKD affects greater than 10% of the population…”
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Coffee inhibition of CYP 3A4 in vitro was not translated to a grapefruit‐like pharmacokinetic interaction clinically by Dresser, George K., Urquhart, Brad L., Proniuk, Julianne, Tieu, Alvin, Freeman, David J., Arnold, John Malcolm, Bailey, David G.

“…Abstract Grapefruit can augment oral medication bioavailability through irreversible (mechanism‐based) inhibition of intestinal CYP 3A4. Supplementary data…”
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Frequent nocturnal hemodialysis associates with improvement of prolonged QTc intervals by Thomson, Benjamin K A, Momciu, Bogdan, Huang, Shih-Han S, Chan, Christopher T, Urquhart, Brad L, Skanes, Allan C, Krahn, Andrew D, Klein, George J, Lindsay, Robert M

“…Sudden cardiac death remains the leading cause of death in hemodialysis (HD) patients. Prolongation of QTc intervals (as measured by the tangent method)…”
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Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial by Craven, Laura, Rahman, Adam, Nair Parvathy, Seema, Beaton, Melanie, Silverman, Justin, Qumosani, Karim, Hramiak, Irene, Hegele, Rob, Joy, Tisha, Meddings, Jon, Urquhart, Brad, Harvie, Ruth, McKenzie, Charles, Summers, Kelly, Reid, Gregor, Burton, Jeremy P, Silverman, Michael

“…Nonalcoholic fatty liver disease (NAFLD) is an obesity-related disorder that is rapidly increasing in incidence and is considered the hepatic manifestation of…”
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Hypersensitivity of HIV-1-infected cells to reactive sulfonamide metabolites correlated to expression of the HIV-1 viral protein tat by Arp, Jacqueline, Rieder, Michael J, Urquhart, Brad, Freeman, David, Tucker, M Jane, Krizova, Adriana, Lehmann, David, Dekaban, Gregory A

“…Impairment of human immunodeficiency virus (HIV)-infected cells to deal with reactive drug metabolites may be a mechanism for the increased rate of adverse…”
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Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial by Craven, Laura, Rahman, Adam, Nair Parvathy, Seema, Beaton, Melanie, Silverman, Justin, Qumosani, Karim, Hramiak, Irene, Hegele, Rob, Joy, Tisha, Meddings, Jon, Urquhart, Brad, Harvie, Ruth, McKenzie, Charles, Summers, Kelly, Reid, Gregor, Burton, Jeremy P., Silverman, Michael

“…Nonalcoholic fatty liver disease (NAFLD) is an obesity-related disorder that is rapidly increasing in incidence and is considered the hepatic manifestation of…”
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