Search Results - "Urosev, Dunja"

Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF by Burtnick, Leslie D, Urosev, Dunja, Irobi, Edward, Narayan, Kartik, Robinson, Robert C

“…The actin filament‐severing functionality of gelsolin resides in its N‐terminal three domains (G1–G3). We have determined the structure of this fragment in…”
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EsiB, a novel pathogenic Escherichia coli secretory immunoglobulin A-binding protein impairing neutrophil activation by Pastorello, Ilaria, Rossi Paccani, Silvia, Rosini, Roberto, Mattera, Rossella, Ferrer Navarro, Mario, Urosev, Dunja, Nesta, Barbara, Lo Surdo, Paola, Del Vecchio, Mariangela, Rippa, Valentina, Bertoldi, Isabella, Gomes Moriel, Danilo, Laarman, Alexander J, van Strijp, Jos A G, Daura, Xavier, Pizza, Mariagrazia, Serino, Laura, Soriani, Marco

“…In this study, we have characterized the functional properties of a novel Escherichia coli antigen named EsiB (E. coli secretory immunoglobulin A-binding…”
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Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold by Urosev, Dunja, Ferrer-Navarro, Mario, Pastorello, Ilaria, Cartocci, Elena, Costenaro, Lionel, Zhulenkovs, Dmitrijs, Maréchal, Jean-Didier, Leonchiks, Ainars, Reverter, David, Serino, Laura, Soriani, Marco, Daura, Xavier

“…Increasing rates of antimicrobial resistance among uropathogens led, among other efforts, to the application of subtractive reverse vaccinology for the…”
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From the first to the second domain of gelsolin: a common path on the surface of actin?1 by Irobi, Edward, Burtnick, Leslie D., Urosev, Dunja, Narayan, Kartik, Robinson, Robert C.

“…We present the 2.6 Å resolution crystal structure of a complex formed between G‐actin and gelsolin fragment Met25–Gln160 (G1+). The structure differs from…”
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The Role of Hydration in Protein Stability: Comparison of the Cold and Heat Unfolded States of Yfh1 by Adrover, Miquel, Martorell, Gabriel, Martin, Stephen R., Urosev, Dunja, Konarev, Petr V., Svergun, Dmitri I., Daura, Xavier, Temussi, Pierandrea, Pastore, Annalisa

“…Protein unfolding occurs at both low and high temperatures, although in most cases, only the high-temperature transition can be experimentally studied. A…”
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Abstract 2641: ZW191, a novel FRa-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload by Lawn, Sam, Rojas, Andrea Hernandez, Colombo, Raffaele, Siddappa, Dayananda, Wong, Jodi, Wu, Kaylee, Fung, Vincent, Urosev, Dunja, Yang, Luying, Rich, Jamie R., Barnscher, Stuart D.

“…Abstract Background: Folate Receptor alpha (FRa) is a validated cell surface cancer target that is prevalently expressed in multiple cancers with high unmet…”
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Abstract 2052: Screening novel format antibodies to design bispecific ADCs that address target heterogeneity by Barnscher, Stuart D., Urosev, Dunja, Yin, Kevin, Rojas, Andrea Hernández, Lawn, Sam, Fung, Vincent, Wong, Jodi, Sagoe-Wagner, Araba, Degefie, Lemlem, Livernois, Ali, Kim, Catrina, Moore, Paul A., Rich, Jamie R.

“…Abstract Addressing inter-patient and intra-tumoral target heterogeneity is a challenge for antibody drug conjugates (ADCs). The most common approach to…”
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Abstract 1862: ZW191 - a FRα-targeting antibody drug conjugate with strong preclinical activity across multiple FRα-expressing indications by Lawn, Sam, Rojas, Andrea Hernandez, Colombo, Raffaele, Wong, Jodi, Wu, Kaylee, Fung, Vincent, Lasalle, Manuel, Petersen, Mark E., Degefie, Lemlem, Sagoe-Wagner, Araba, Urosev, Dunja, Yang, Luying, Wu, Ambroise, Kim, Catrina, Chua, Amos, Stahl, Kurt, Winters, Geoffrey C., Fann, John C., Rich, Jamie, Barnscher, Stuart

“…Abstract Background: Folate Receptor alpha (FRα) is a validated cancer target that is prevalently expressed in multiple cancers with high unmet need, including…”
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Abstract 1533: ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload by Rojas, Andrea Hernandez, Wong, Jodi, Urosev, Dunja, Lawn, Sam, Wu, Kaylee, Konomura, Saki, Lasalle, Manuel, Alonzo, Diego A., Yang, Luying, Petersen, Mark, Degefie, Lemlem T., Sagoe-Wagner, Araba P., Kang, Sohyeong, Cheng, Chi Wing, Colombo, Raffaele, Siddappa, Daya, Barnscher, Stuart D., Rich, Jamie R.

“…Abstract Background: NaPi2b is a multi-pass transmembrane sodium-dependent phosphate transport protein encoded by the gene SLC34A2. NaPi2b is involved in…”
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Abstract 2658: ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload by Madera, Laurence, Rojas, Andrea Hernández, Colombo, Raffaele, Wu, Alex, Piscitelli, Chayne L., Urosev, Dunja, Bissessur, Allysha, Cheng, Chi Wing, Duan, Renee, Kim, Catrina, Yin, Kevin, Fung, Vincent, Wu, Kaylee, Cheung, Winnie, Alonzo, Diego A., Petersen, Mark E., Barnscher, Stuart D., Rich, Jamie R.

“…Abstract Background: Glypican-3 (GPC3) is a cell-surface oncofetal glycoprotein frequently expressed in hepatocellular carcinoma (HCC) with minimal presence in…”
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From the first to the second domain of gelsolin: a common path on the surface of actin? by Irobi, Edward, Burtnick, Leslie D., Urosev, Dunja, Narayan, Kartik, Robinson, Robert C.

“…We present the 2.6 Å resolution crystal structure of a complex formed between G-actin and gelsolin fragment Met25–Gln160 (G1+). The structure differs from…”
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The Structure of Gelsolin Bound to ATP by Urosev, Dunja, Ma, Qing, Tan, Agnes L.C., Robinson, Robert C., Burtnick, Leslie D.

“…Calcium activation of the actin-modifying properties of gelsolin is sensitive to ATP. Here, we show that soaking calcium-free gelsolin crystals in…”
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Calcium Ion Exchange in Crystalline Gelsolin by Chumnarnsilpa, Sakesit, Loonchanta, Anantasak, Xue, Bo, Choe, Han, Urosev, Dunja, Wang, Hui, Lindberg, Uno, Burtnick, Leslie D., Robinson, Robert C.

“…Gelsolin is a calcium and pH-sensitive modulator of actin filament length. Here, we use X-ray crystallography to examine the extraction and exchange of calcium…”
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Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin by Narayan, Kartik, Chumnarnsilpa, Sakesit, Choe, Han, Irobi, Edward, Urosev, Dunja, Lindberg, Uno, Schutt, Clarence E., Burtnick, Leslie D., Robinson, Robert C.

“…Gelsolin requires activation to carry out its severing and capping activities on F-actin. Here, we present the structure of the isolated C-terminal half of…”
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Activation in isolation: exposure of the actin‐binding site in the C‐terminal half of gelsolin does not require actin1 by Narayan, Kartik, Chumnarnsilpa, Sakesit, Choe, Han, Irobi, Edward, Urosev, Dunja, Lindberg, Uno, Schutt, Clarence E., Burtnick, Leslie D., Robinson, Robert C.

“…Gelsolin requires activation to carry out its severing and capping activities on F‐actin. Here, we present the structure of the isolated C‐terminal half of…”
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Activation in isolation: exposure of the actin‐binding site in the C‐terminal half of gelsolin does not require actin 1 by Narayan, Kartik, Chumnarnsilpa, Sakesit, Choe, Han, Irobi, Edward, Urosev, Dunja, Lindberg, Uno, Schutt, Clarence E., Burtnick, Leslie D., Robinson, Robert C.

“…Gelsolin requires activation to carry out its severing and capping activities on F‐actin. Here, we present the structure of the isolated C‐terminal half of…”
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Localization of calponin binding sites in the structure of 90 kDa heat shock protein (Hsp90) by Bogatcheva, Natalia V, Ma, YuShu, Urosev, Dunja, Gusev, Nikolai B

“…The structure of rabbit liver Hsp90 was reevaluated by limited trypsinolysis, N-terminal sequencing and determination of the site that is phosphorylated by…”
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