Search Results - "Uronis, Joshua M"

Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer by Arthur, Janelle C., Gharaibeh, Raad Z., Mühlbauer, Marcus, Perez-Chanona, Ernesto, Uronis, Joshua M., McCafferty, Jonathan, Fodor, Anthony A., Jobin, Christian

“…Enterobacteria, especially Escherichia coli , are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear…”
Get full text

Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility by Uronis, Joshua M, Mühlbauer, Marcus, Herfarth, Hans H, Rubinas, Tara C, Jones, Gieira S, Jobin, Christian

“…It is well established that the intestinal microbiota plays a key role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) collectively…”
Get full text

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota by Arthur, Janelle C., Perez-Chanona, Ernesto, Mühlbauer, Marcus, Tomkovich, Sarah, Uronis, Joshua M., Fan, Ting-Jia, Campbell, Barry J., Abujamel, Turki, Dogan, Belgin, Rogers, Arlin B., Rhodes, Jonathan M., Stintzi, Alain, Simpson, Kenneth W., Hansen, Jonathan J., Keku, Temitope O., Fodor, Anthony A., Jobin, Christian

“…Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a…”
Get full text

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer by Allen, Irving C, TeKippe, Erin McElvania, Woodford, Rita-Marie T, Uronis, Joshua M, Holl, Eda K, Rogers, Arlin B, Herfarth, Hans H, Jobin, Christian, Ting, Jenny P-Y

“…Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the inflammasome are protective during acute…”
Get full text

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling by Allen, Irving C., Wilson, Justin E., Schneider, Monika, Lich, John D., Roberts, Reid A., Arthur, Janelle C., Woodford, Rita-Marie T., Davis, Beckley K., Uronis, Joshua M., Herfarth, Hans H., Jobin, Christian, Rogers, Arlin B., Ting, Jenny P.-Y.

“…In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription factor NF-κB, although physiologic and disease-relevant…”
Get full text

Mesenchymal gene expression subtyping analysis for early-stage human papillomavirus-negative head and neck squamous cell carcinoma reveals prognostic and predictive applications by Mayhew, Gregory M., Uronis, Joshua M., Hayes, David Neil, Zevallos, Jose P.

“…Patients with oral cavity squamous cell carcinoma (OCSCC) are predominantly human papillomavirus (HPV)(−), and treatment typically involves surgical resection…”
Get full text

Histological and molecular evaluation of patient-derived colorectal cancer explants by Uronis, Joshua M, Osada, Takuya, McCall, Shannon, Yang, Xiao Yi, Mantyh, Christopher, Morse, Michael A, Lyerly, H Kim, Clary, Bryan M, Hsu, David S

“…Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and…”
Get full text

Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience by Rose, Tracy L., Weir, William H., Mayhew, Gregory M., Shibata, Yoichiro, Eulitt, Patrick, Uronis, Joshua M., Zhou, Mi, Nielsen, Matthew, Smith, Angela B., Woods, Michael, Hayward, Michele C., Salazar, Ashley H., Milowsky, Matthew I., Wobker, Sara E., McGinty, Katrina, Millburn, Michael V., Eisner, Joel R., Kim, William Y.

“…Background FGFR3-altered urothelial cancer (UC) correlates with a non-T cell-inflamed phenotype and has therefore been postulated to be less responsive to…”
Get full text

VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer by Arthur, Janelle C., Gharaibeh, Raad Z., Uronis, Joshua M., Perez-Chanona, Ernesto, Sha, Wei, Tomkovich, Sarah, Mühlbauer, Marcus, Fodor, Anthony A., Jobin, Christian

“…Although probiotics have shown success in preventing the development of experimental colitis-associated colorectal cancer (CRC), beneficial effects of…”
Get full text

Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer: The Piedmont Study by Eisner, Joel R, Mayhew, Gregory M, Davison, James M, Beebe, Kirk D, Shibata, Yoichiro, Guo, Yuelong, Farhangfar, Carol, Farhangfar, Farhang, Uronis, Joshua M, Conroy, Jeffrey M, Milburn, Michael V, Hayes, David Neil, Mileham, Kathryn F

“…The Piedmont study is a prospectively designed retrospective evaluation of a new 48-gene antifolate response signature (AF-PRS) in patients with locally…”
Get full text

Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling by Goldsmith, Jason R, Uronis, Joshua M, Jobin, Christian

“…Opiates have long been used as analgesics to relieve pain associated with various medical conditions. Here, we evaluated the effect and mechanism of mu opioid…”
Get full text

Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS‐induced colitis by Uronis, Joshua M., Arthur, Janelle C., Keku, Temitope, Fodor, Anthony, Carroll, Ian M., Cruz, Myrella L., Appleyard, Caroline B., Jobin, Christian

“…Background: Compositional changes within the normal intestinal microbiota have been associated with the development of various intestinal inflammatory…”
Get full text

Correction to: Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience by Rose, Tracy L., Weir, William H., Mayhew, Gregory M., Shibata, Yoichiro, Eulitt, Patrick, Uronis, Joshua M., Zhou, Mi, Nielsen, Matthew, Smith, Angela B., Woods, Michael, Hayward, Michele C., Salazar, Ashley H., Milowsky, Matthew I., Wobker, Sara E., McGinty, Katrina, Millburn, Michael V., Eisner, Joel R., Kim, William Y.

Get full text

Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer by Eisner, Joel R, Beebe, Kirk D, Mayhew, Gregory M, Shibata, Yoichiro, Guo, Yuelong, Farhangfar, Carol, Farhangfar, Farhang, Uronis, Joshua M, Mooney, Jill, Milburn, Michael V, Foureau, David, White, Richard L, Amin, Asim, Milla, Marcos E

“…Recombinant human high-dose IL2 (HD-IL2; aldesleukin) was one of the first approved immune-oncology agents based upon clinical activity in renal cell carcinoma…”
Get full text

Murine models of colorectal cancer by Uronis, Joshua M, Threadgill, David W

“…Colorectal cancer is one of the most prevalent cancers of humans. To experimentally investigate this common disease, numerous murine models have been…”
Get full text

Mu Opioid Signaling and STAT3 Activation Protects Against Acute Murine Intestinal Injury in Mice by Goldsmith, Jason R, Uronis, Joshua M, Gipson, Gregory, Jobin, Christian

Get full text

PKCα tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1 by Pysz, Marybeth A., Leontieva, Olga V., Bateman, Nicholas W., Uronis, Joshua M., Curry, Kathryn J., Threadgill, David W., Janssen, Klaus-Peter, Robine, Sylvie, Velcich, Anna, Augenlicht, Leonard H., Black, Adrian R., Black, Jennifer D.

“…Alterations in PKC isozyme expression and aberrant induction of cyclin D1 are early events in intestinal tumorigenesis. Previous studies have identified cyclin…”
Get full text

28 PI3K Signaling Mediates Campylobacter Jejuni Induced Colitis in IL 10-/- Mice by Sun, Xiaolun, Uronis, Joshua M, Jarvis, Ward, Kim, Sandra C, Jobin, Christian

Get full text

Flat Colorectal Cancers Are Genetically Determined and Progress to Invasion without Going through a Polypoid Stage by URONIS, Joshua M, HERFARTH, Hans H, RUBINAS, Tara C, BISSAHOYO, Anika C, HANLON, Kathleen, THREADGILL, David W

“…Growing evidence suggests that flat colorectal cancers (CRC) account for 10% to 20% of all CRCs and that these are frequently associated with more advanced…”
Get full text

Inflammation Impacts the Development of Colorectal Cancer Through Changes in Microbial Composition and Associated Genotoxic Capacity by Arthur, Janelle C, Uronis, Joshua M, Perez Chanona, Ernesto, Keku, Temitope O, Muehlbauer, Marcus, Tomkovich, Sarah E, Fan, Ting-Jia, Hansen, Jonathan J, Jobin, Christian

Get full text