Search Results - "Urge, L"

Recent advances in chemical genomics by Darvas, F, Dormán, G, Krajcsi, P, Puskás, L G, Kovári, Z, Lörincz, Z, Urge, L

“…Chemical genomics, which utilizes specially designed small chemical compounds early in the discovery phase of new drugs to explore the life science at various…”
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Selective Peptide Antagonist of the Class E Calcium Channel from the Venom of the Tarantula Hysterocrates gigas by Newcomb, Robert, Szoke, Balazs, Palma, Andrew, Wang, Gang, Chen, Xiao-hua, Hopkins, William, Cong, Ruth, Miller, Jim, Urge, Laszlo, Tarczy-Hornoch, Katalin, Loo, Joseph A, Dooley, David J, Nadasdi, Laszlo, Tsien, Richard W, Lemos, José, Miljanich, George

“…We describe the first potent and selective blocker of the class E Ca2+channel. SNX-482, a novel 41 amino acid peptide present in the venom of the African…”
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Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament (NF-M) protein by Hollósi, M, Urge, L, Perczel, A, Kajtár, J, Teplán, I, Otvös, Jr, L, Fasman, G D

“…The NF-M subunit of human neurofilaments has a C-terminal repeating 13-mer sequence. The 13-mer (Lys-Ser-Pro-Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly) (NF-M13)…”
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Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine-2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-ones via a rearrangement by Varga, László, Nagy, Tamás, Kövesdi, István, Benet-Buchholz, Jordi, Dormán, György, Ürge, László, Darvas, Ferenc

“…The reaction of chalcones and guanidine was investigated in the presence of an oxidizing agent. Depending on the order of the addition either a…”
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Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects by Hoffmann, Ralf, Bulet, Philippe, Urge, Laszlo, Otvös, Laszlo

“…Antibacterial glycopeptides isolated from insects are exciting bio-oligomers because they represent a family of compounds in which the structural and…”
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Cassava root chips andMoringa oleifera leaf meal as alternative feed ingredients in the layer ration by Tesfaye, Etalem B., Animut, Getachew M., Urge, Mengistu L., Dessie, Tadelle A.

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Peptide stability in drug development. II: Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum by POWELL, M. F, STEWART, T, OTVOS, L. JR, URGE, L, GAETA, F. C. A, SETTE, A, ARRHENIUS, T, THOMSON, D, SODA, K, COLON, S. M

“…The determination of peptide stability in human serum (HS) or plasma constitutes a powerful screening assay for eliminating unstable peptides from further…”
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Combinatorial chemistry. Facing the challenge of chemical genomics by Darvas, Ferenc, Dorman, Gyorgy, Urge, Laszlo, Szabo, Istvan, Ronai, Zsolt, Sasvari-Szekely, Maria

“…In the age of high-throughput screening and combinatorial chemistry, the focus of drug discovery is to replace the sequential approach with the most effective…”
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Introduction of a Glycosylation Site into a Secreted Protein Provides Evidence for an Alternative Antigen Processing Pathway: Transport of Precursors of Major Histocompatability Complex Class I–Restricted Peptides from the Endoplasmic Reticulum to the Cytosol by Bačík, Igor, Snyder, Heidi Link, Antón, Luis C., Russ, Gustav, Chen, Weisan, Bennink, Jack R., Urge, Laszlo, Otvos, Laszlo, Dudkowska, Boguslawa, Eisenlohr, Laurence, Yewdell, Jonathan W.

“…We found that the presentation of a H-2Kd-restricted determinant from influenza virus nucleoprotein (NP) to T cells is strictly dependent on expression of the…”
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Synthesis and conformational studies of N-glycosylated analogs of the HIV-1 principal neutralizing determinant by Laczko, Ilona, Hollosi, Miklos, Urge, Laszlo, Ugen, Kenneth E, Weiner, David B, Mantsch, Henry H, Thurin, Jan, Otvos, Laszlo

“…The principal neutralizing determinant (PND) of HIV-1 is found in the V3 loop of the envelope glycoprotein. Antibodies elicited by peptides from this region,…”
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Osteopontin in urinary stone formation by Hoyer, J R, Otvos, Jr, L, Urge, L

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Enantioselective plasma protein binding of bimoclomol by Visy, Júlia, Fitos, Ilona, Mády, György, Ürge, László, Krajcsi, Péter, Simonyi, Miklós

“…The binding of bimoclomol enantiomers to human plasma, its components, as well as to plasma from monkey, dog, rat, and mouse was investigated by…”
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Ca(2+)-induced conformational transitions of phosphorylated peptides by Hollósi, M, Otvös, Jr, L, Urge, L, Kajtár, J, Perczel, A, Laczkó, I, Vadász, Z, Fasman, G D

“…CD spectroscopic studies on protected peptides containing lysine and serine, or phosphoserine, and on serine-containing fragments of the neurofilament protein…”
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Zur Geschichte der Tuberkulosebekämpfung in der CSSR: die ost-slowakischen Mykobakteriologie-Tbk-Seminare in Vysne Hagy und in Presov by Linkesch, W, Urge, L, Lukac, J, Hejny, J

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Enlarged scale chemical synthesis and range of activity of drosocin, an O-glycosylated antibacterial peptide of Drosophila by Bulet, P, Urge, L, Ohresser, S, Hetru, C, Otvos, L. Jr

“…Insects respond to a bacterial challenge by rapidly synthesizing a diverse range of antibacterial and antifungal peptides. One of them, drosocin, a 19-residue…”
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Chemical glycosylation of peptide T at natural and artificial glycosylation sites stabilizes or rearranges the dominant reverse turn structure by Urge, L, Gorbics, L, Otvos, Jr, L

“…Peptide T (H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH), a fragment of HIV gp120, has been reported to inhibit binding of the virus to the CD4 receptor. The peptide…”
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Continuous-Flow High Pressure Hydrogenation Reactor for Optimization and High-Throughput Synthesis by Jones, Richard V, Godorhazy, Lajos, Varga, Norbert, Szalay, Daniel, Urge, Laszlo, Darvas, Ferenc

“…This paper reports on a novel continuous-flow hydrogenation reactor and its integration with a liquid handler to generate a fully automated high-throughput…”
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Comparative and optimized dabsyl-amino acid analysis of synthetic phosphopeptides and glycopeptides by Gorbics, L, Urge, L, Otvos, Jr, L

“…The optimal conditions for amino acid analysis of phosphopeptides and N-acetylglucosamine- and N-acetylgalactosamine-containing glycopeptides were investigated…”
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Circular dichroism study of the carbohydrate-modified opioid peptides by Horvat, Štefica, Otvos, Laszlo, Urge, Laszlo, Horvat, Jaroslav, Čudić, Mare, Varga-Defterdarović, Lidija

“…The conformational preferences of enkephalins and the related glycoconjugates in which free or protected carbohydrate moieties were linked to the opioid…”
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Fmoc-protected, glycosylated asparagines potentially useful as reagents in the solid-phase synthesis of N-glycopeptides by Urge, L, Otvos, Jr, L, Lang, E, Wroblewski, K, Laczko, I, Hollosi, M

“…1-Amino 1-deoxy derivatives of unprotected O-beta-D-galactopyranosyl-(1-->3)-2-acetamido-2-deoxy-beta-D-glucopyrano se, 2-acetamido-2-deoxy-D-galactose,…”
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