Search Results - "Uren, Philip J."

Aberrant sperm DNA methylation predicts male fertility status and embryo quality by Aston, Kenneth I., Ph.D, Uren, Philip J., Ph.D, Jenkins, Timothy G., Ph.D, Horsager, Alan, Ph.D, Cairns, Bradley R., Ph.D, Smith, Andrew D., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate whether male fertility status and/or embryo quality during in vitro fertilization (IVF) therapy can be predicted based on genomewide…”
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Riborex: fast and flexible identification of differential translation from Ribo-seq data by Li, Wenzheng, Wang, Weili, Uren, Philip J, Penalva, Luiz O F, Smith, Andrew D

“…Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach provides…”
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Site identification in high-throughput RNA―protein interaction data by UREN, Philip J, BAHRAMI-SAMANI, Emad, BURNS, Suzanne C, MEI QIAO, KARGINOV, Fedor V, HODGES, Emily, HANNON, Gregory J, SANFORD, Jeremy R, PENALVA, Luiz O. F, SMITH, Andrew D

“…Post-transcriptional and co-transcriptional regulation is a crucial link between genotype and phenotype. The central players are the RNA-binding proteins, and…”
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Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment by Hodges, Emily, Molaro, Antoine, Dos Santos, Camila O., Thekkat, Pramod, Song, Qiang, Uren, Philip J., Park, Jin, Butler, Jason, Rafii, Shahin, McCombie, W. Richard, Smith, Andrew D., Hannon, Gregory J.

“…DNA methylation has been implicated as an epigenetic component of mechanisms that stabilize cell-fate decisions. Here, we have characterized the methylomes of…”
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IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC by Ennajdaoui, Hanane, Howard, Jonathan M., Sterne-Weiler, Timothy, Jahanbani, Fereshteh, Coyne, Doyle J., Uren, Philip J., Dargyte, Marija, Katzman, Sol, Draper, Jolene M., Wallace, Andrew, Cazarez, Oscar, Burns, Suzanne C., Qiao, Mei, Hinck, Lindsay, Smith, Andrew D., Toloue, Masoud M., Blencowe, Benjamin J., Penalva, Luiz O.F., Sanford, Jeremy R.

“…Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We…”
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Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells by dos Santos, Camila O., Rebbeck, Clare, Rozhkova, Elena, Valentine, Amy, Samuels, Abigail, Kadiri, Lolahon R., Osten, Pavel, Harris, Elena Y., Uren, Philip J., Smith, Andrew D., Hannon, Gregory J.

“…The partial purification of mouse mammary gland stem cells (MaSCs) using combinatorial cell surface markers (Lin⁻CD24⁺CD29 h CD49f h ) has improved our…”
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Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit by de Araujo, Patricia Rosa, Gorthi, Aparna, da Silva, Acarizia E., Tonapi, Sonal S., Vo, Dat T., Burns, Suzanne C., Qiao, Mei, Uren, Philip J., Yuan, Zhi-Min, Bishop, Alexander J.R., Penalva, Luiz O.F.

“…The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and…”
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The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis by Vo, Dat T, Subramaniam, Dharmalingam, Remke, Marc, Burton, Tarea L, Uren, Philip J, Gelfond, Jonathan A, de Sousa Abreu, Raquel, Burns, Suzanne C, Qiao, Mei, Suresh, Uthra, Korshunov, Andrey, Dubuc, Adrian M, Northcott, Paul A, Smith, Andrew D, Pfister, Stefan M, Taylor, Michael D, Janga, Sarath C, Anant, Shrikant, Vogel, Christine, Penalva, Luiz O.F

“…Musashi1 (Msi1) is a highly conserved RNA-binding protein that is required during the development of the nervous system. Msi1 has been characterized as a stem…”
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Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells by Tamim, Saleh, Vo, Dat T, Uren, Philip J, Qiao, Mei, Bindewald, Eckart, Kasprzak, Wojciech K, Shapiro, Bruce A, Nakaya, Helder I, Burns, Suzanne C, Araujo, Patricia R, Nakano, Ichiro, Radek, Agnes J, Kuersten, Scott, Smith, Andrew D, Penalva, Luiz O F

“…miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its…”
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Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation by Abbasi, Mohammad, Smith, Andrew D, Swaminathan, Harish, Sangngern, Peer, Douglas, Amanda, Horsager, Alan, Carrell, Douglas T, Uren, Philip J

“…Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of…”
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Computational challenges, tools, and resources for analyzing co- and post-transcriptional events in high throughput by Bahrami-Samani, Emad, Vo, Dat T., de Araujo, Patricia Rosa, Vogel, Christine, Smith, Andrew D., Penalva, Luiz O. F., Uren, Philip J.

“…Co‐ and post‐transcriptional regulation of gene expression is complex and multifaceted, spanning the complete RNA lifecycle from genesis to decay…”
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RNA binding protein HuR regulates the expression of ABCA1[S] by Ramírez, Cristina M., Lin, Chin Sheng, Abdelmohsen, Kotb, Goedeke, Leigh, Yoon, Je-Hyun, Madrigal-Matute, Julio, Martin-Ventura, Jose L., Vo, Dat T., Uren, Philip J., Penalva, Luiz O., Gorospe, Myriam, Fernández-Hernando, Carlos

“…ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established,…”
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Leveraging cross-link modification events in CLIP-seq for motif discovery by Bahrami-Samani, Emad, Penalva, Luiz O F, Smith, Andrew D, Uren, Philip J

“…High-throughput protein-RNA interaction data generated by CLIP-seq has provided an unprecedented depth of access to the activities of RNA-binding proteins…”
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High-throughput analyses of hnRNP H1 dissects its multi-functional aspect by Uren, Philip J., Bahrami-Samani, Emad, de Araujo, Patricia Rosa, Vogel, Christine, Qiao, Mei, Burns, Suzanne C., Smith, Andrew D., Penalva, Luiz O. F.

“…hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles including splicing, mRNA decay, translation, and miRNA…”
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Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites by Uren, Philip J., Burns, Suzanne C., Ruan, Jianhua, Singh, Kusum K., Smith, Andrew D., Penalva, Luiz O.F.

“…The ubiquitously expressed RNA-binding protein Hu antigen R (HuR) or ELAVL1 is implicated in a variety of biological processes as well as being linked with a…”
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RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma by Uren, Philip J., Vo, Dat T., de Araujo, Patricia Rosa, Pötschke, Rebecca, Burns, Suzanne C., Bahrami-Samani, Emad, Qiao, Mei, de Sousa Abreu, Raquel, Nakaya, Helder I., Correa, Bruna R., Kühnöl, Caspar, Ule, Jernej, Martindale, Jennifer L., Abdelmohsen, Kotb, Gorospe, Myriam, Smith, Andrew D., Penalva, Luiz O. F.

“…The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its…”
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Large-scale heterogeneous disruption of sperm dna-methylation in infertile individuals is associated with genes implicated in sperm chemotaxis, acrosome reaction and egg-binding by Uren, Philip J, Williamson, La-Toya, Karsian, Mike, Carrell, Douglas, Smith, Andrew D, Horsager, Alan

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A profile of transcriptomic changes in the rd10 mouse model of retinitis pigmentosa by Uren, Philip J, Lee, Justine T, Doroudchi, M Mehdi, Smith, Andrew D, Horsager, Alan

“…Retinitis pigmentosa (RP) is a photoreceptor disease that affects approximately 100,000 people in the United States. Treatment options are limited, and the…”
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Prophylactic dose enoxaparin may increase pregnancy rates in men with aberrant sperm methylation profiles by Leahey, Jocelyn, Williamson, La-Toya, Horsager, Alan, Uren, Philip J., Eyvazzadeh, Aimee

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Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-PKcs by de Araujo, Patricia Rosa, Gorthi, Aparna, da Silva, Acarizia Eduardo, Tonapi, Sonal S, Vo, Dat T, Burns, Suzanne C, Qiao, Mei, Uren, Philip J, Yuan, Zhi-Min, Bishop, Alexander J.R, Penalva, Luiz O.F

“…The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and…”
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