Cd36 gene expression in adipose and hepatic tissue mediates the lipids accumulation in liver of obese rats with sucrose-induced hepatic steatosis

Cd36 gene expression in adipose and hepatic tissue mediates the lipids accumulation in liver of obese rats with sucrose-induced hepatic steatosis

•Relative expression of the cd36 gene associated with the development of hepatic steatosis.•Chronic sucrose intake associated with the development of obesity and fatty liver non-alcoholic disease.•Specific tissue involvement of the expression of Cd36 mRNA in rats with obesity and hepatic steatosis....

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Bibliographic Details
Published in:Prostaglandins & other lipid mediators Vol. 147; p. 106404
Main Authors: Quintana-Castro, Rodolfo, Aguirre-Maldonado, Isaac, Soto-Rodríguez, Ida, Deschamps-Lago, Rosa A., Gruber-Pagola, Peter, Urbina de Larrea, Yolanda K., Juárez-Rivera, Victoria E., Ramos-Manuel, Luis E., Alexander-Aguilera, Alfonso
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-04-2020
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - pathology
Animals
CD36 Antigens - metabolism
Cd36 gene
Disease Models, Animal
Fatty Liver - etiology
Fatty Liver - metabolism
Fatty Liver - pathology
Hepatic steatosis
Lipids - analysis
Liver - metabolism
Liver - pathology
Male
Obesity
Obesity - chemically induced
Obesity - complications
Obesity - metabolism
Rats
Rats, Wistar
sCD36
Sucrose
Sucrose - toxicity
Sweetening Agents - toxicity
Obesity
Adipose tissue
sCD36
Hepatic steatosis
Cd36 gene
Sucrose
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Summary:•Relative expression of the cd36 gene associated with the development of hepatic steatosis.•Chronic sucrose intake associated with the development of obesity and fatty liver non-alcoholic disease.•Specific tissue involvement of the expression of Cd36 mRNA in rats with obesity and hepatic steatosis. Obesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD). The pathogenesis between obesity and hepatic steatosis is partially known, but could involve differentiated or tissue-specific participation of the expression of Cd36 mRNA that codes for a receptor which is a transporter of free fatty acids (FFA) in different tissues, favoring the lipids storage. This relative expression was evaluated in adipose and liver tissue in rats with steatosis after consumption of sucrose for 30 and 40 weeks. Ten Wistar rats were divided into two experimental groups (St-30 and St-40), which received a standard diet plus 30 % sucrose in their water intake. These rats showed a significant increase in abdominal fat, serum biochemical determinations, HOMA-IR; as well as, changes in adipocytes size and mild portal hepatitis and grade 2 hepatic steatosis. The relative expression of Cd36 mRNA increased in liver tissue after 30 (4.5-fold) and 40 (8.5-fold) weeks of sucrose ingestión but no in adipose tissue; with respect to control group (P < 0.05). This expression was associated with a significant increase in the levles of sCD36 in serum, which is indicator of the presence of the FFA transporter in the hepatocyte membrane causing lipids accumulation. The above shows the link between the adipose and hepatic tissue for the accumulation of steatotic fat in the liver through time, mediated by the relative expression of cd36 mRNA that encodes for the FFA transporter.
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2019.106404