Search Results - "Urbani, Ginevra"

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH by Marchianò, Silvia, Biagioli, Michele, Morretta, Elva, Di Giorgio, Cristina, Roselli, Rosalinda, Bordoni, Martina, Bellini, Rachele, Urbani, Ginevra, Massa, Carmen, Monti, Maria Chiara, Zampella, Angela, Distrutti, Eleonora, Fiorucci, Stefano

“…Non-alcoholic steatosis (NAFLD) and steatohepatitis (NASH) are two highly prevalent human disorders for which therapy remains suboptimal. Bile acids are…”
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Role of mRAGEs and ACE2 in SARS-CoV-2-Related Inflammation by Fiorucci, Stefano, Urbani, Ginevra

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Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases by Biagioli, Michele, Di Giorgio, Cristina, Morretta, Elva, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Bordoni, Martina, Marchianò, Silvia, Lachi, Ginevra, Sepe, Valentina, Monti, Maria Chiara, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

“…Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and…”
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GDF15 in Vascular and Liver Metabolic Disorders: A Novel Therapeutic Target by Fiorucci, Stefano, Urbani, Ginevra

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Bile Acids-Based Therapies for Primary Sclerosing Cholangitis: Current Landscape and Future Developments by Fiorucci, Stefano, Urbani, Ginevra, Di Giorgio, Cristina, Biagioli, Michele, Distrutti, Eleonora

“…Primary sclerosing cholangitis (PSC) is a rare, chronic liver disease with no approved therapies. The ursodeoxycholic acid (UDCA) has been widely used,…”
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Current Landscape and Evolving Therapies for Primary Biliary Cholangitis by Fiorucci, Stefano, Urbani, Ginevra, Di Giorgio, Cristina, Biagioli, Michele, Distrutti, Eleonora

“…Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disorder characterized by progressive cholestatic that, if untreated, can progress to liver…”
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Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis by Di Giorgio, Cristina, Marchianò, Silvia, Marino, Elisabetta, Biagioli, Michele, Roselli, Rosalinda, Bordoni, Martina, Bellini, Rachele, Urbani, Ginevra, Zampella, Angela, Distrutti, Eleonora, Donini, Annibale, Graziosi, Luigina, Fiorucci, Stefano

“…Gastric cancer (GC) is the third cause of cancer-related mortality worldwide. Nevertheless, because GC screening programs are not cost-effective, most patients…”
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Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma by Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, Sepe, Valentina, Rapacciuolo, Pasquale, Moraca, Federica, Morretta, Elva, Ricci, Patrizia, Urbani, Ginevra, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano

“…The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including…”
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Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease by Marchianò, Silvia, Biagioli, Michele, Bordoni, Martina, Morretta, Elva, Di Giorgio, Cristina, Vellecco, Valentina, Roselli, Rosalinda, Bellini, Rachele, Massa, Carmen, Cari, Luigi, Urbani, Ginevra, Ricci, Patrizia, Monti, Maria Chiara, Giordano, Antonino, Brancaleone, Vincenzo, Bucci, Mariarosaria, Zampella, Angela, Distrutti, Eleonora, Cieri, Enrico, Cirino, Giuseppe, Fiorucci, Stefano

“…Patients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile…”
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The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer by Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Urbani, Ginevra, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, De Gregorio, Rosa, Rapacciuolo, Pasquale, Sepe, Valentina, Morretta, Elva, Monti, Maria Chiara, Moraca, Federica, Cari, Luigi, Ullah, Khan Rana Sami, Natalizi, Nicola, Graziosi, Luigina, Distrutti, Eleonora, Biagioli, Michele, Catalanotti, Bruno, Donini, Annibale, Zampella, Angela, Fiorucci, Stefano

“…Purpose The gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain sub-optimal…”
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Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma by Di Giorgio, Cristina, Lupia, Antonio, Marchianò, Silvia, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Roselli, Rosalinda, Moraca, Federica, Sepe, Valentina, Catalanotti, Bruno, Morretta, Elva, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

“…Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While…”
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Bile acids and bile acid activated receptors in the treatment of Covid-19 by Fiorucci, Stefano, Urbani, Ginevra, Biagioli, Michele, Sepe, Valentina, Distrutti, Eleonora, Zampella, Angela

“…[Display omitted] Since its first outbreak in 2020, the pandemic caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has caused the…”
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Immunology of bile acids regulated receptors by Fiorucci, Stefano, Marchianò, Silvia, Urbani, Ginevra, Di Giorgio, Cristina, Distrutti, Eleonora, Zampella, Angela, Biagioli, Michele

“…Bile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from…”
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Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling by Marchianò, Silvia, Biagioli, Michele, Roselli, Rosalinda, Zampella, Angela, Di Giorgio, Cristina, Bordoni, Martina, Bellini, Rachele, Urbani, Ginevra, Morretta, Elva, Monti, Maria Chiara, Distrutti, Eleonora, Fiorucci, Stefano

“…Non-alcoholic steatosis (NAFLD) and steatohepatitis (NASH) are two highly prevalent human disorders for which therapy remains suboptimal. Bile acids play an…”
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Tu1726 GPBAR1 AGONISM AND SIMULTANEOUS RORΓT INVERSE AGONISM AS A NOVEL PROMISING THERAPY FOR THE TREATMENT OF IBD by Biagioli, Michele, Giorgio, Cristina Di, Marchianò, Silvia, Bellini, Rachele, Massa, Carmen, Bordoni, Martina, Urbani, Ginevra, Lachi, Ginevra, Khan, Rana Sami Ullah, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

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Sa1563 BAR502 AS A PROMISING THERAPY FOR METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS: INSIGHTS FROM MURINE MODEL STUDIES by Marchianò, Silvia, Biagioli, Michele, Giorgio, Cristina Di, Urbani, Ginevra, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Lachi, Ginevra, Monti, Maria Chiara, Zampella, Angela, Fiorucci, Stefano

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Sa1749 DISCOVERY OF NEW MOLECULE; AGONIST OF GPBAR1 AND INVERSE AGONIST OF RORΓT, FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES by Biagioli, Michele, Giorgio, Cristina Di, Roselli, Rosalinda, Bellini, Rachele, Bordoni, Martina, Marchianò, Silvia, Massa, Carmen, Urbani, Ginevra, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

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Mo1801 BILE ACID METABOLITES REGULATE INTESTINAL IMMUNITY BY ACTING AS GPBAR1 AGONIST AND RORΓT INVERSE AGONIST MODULATING THE BALANCE OF TH17/TREG AND M1/M2 MACROPHAGES by Biagioli, Michele, Roselli, Rosalinda, Giorgio, Cristina Di, Marchianò, Silvia, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Monti, Maria Chiara, Morretta, Elva, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

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217 BAR502, A DUAL FXR AND GPBAR1 AGONIST, SYNERGIZED ATORVASTATIN BENEFICIAL EFFECTS ON VASCULAR INFLAMMATION IN NASH by Marchianò, Silvia, Biagioli, Michele, Giorgio, Cristina Di, Bordoni, Martina, Bellini, Rachele, Roselli, Rosalinda, Massa, Carmen, Urbani, Ginevra, Distrutti, Eleonora, Morretta, Elva, Monti, Maria Chiara, Zampella, Angela, Fiorucci, Stefano

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Su1416 NATURAL AND SYNTHETIC BILE ACIDS FUNCTION AS LEUKEMYA INHIBITORY FACTOR RECEPTOR (LIFR) ANTAGONISTS AND REVERT PROLIFERATION AND MIGRATION IN PANCREATIC CANCER CELL LINES by Giorgio, Cristina Di, Bellini, Rachele, Lupia, Antonio, Roselli, Rosalinda, Massa, Carmen, Bordoni, Martina, Urbani, Ginevra, Marchianò, Silvia, Biagioli, Michele, Fiorillo, Bianca, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano

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