Search Results - "Urban, P. J."

ISSLS PRIZE in Clinical Science 2023: comparison of degenerative MRI features of the intervertebral disc between those with and without chronic low back pain. An exploratory study of two large female populations using automated annotation by Jamaludin, A., Kadir, T., Zisserman, A., McCall, I., Williams, F. M. K., Lang, H., Buchanan, E., Urban, J. P. G., Fairbank, J. C. T.

“…Objectives The relationship of degeneration to symptoms has been questioned. MRI detects apparently similar disc degeneration and degenerative changes in…”
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Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population by Shirazi-Adl, A, Taheri, M, Urban, J.P.G

“…Abstract Responsible for making and maintaining the extracellular matrix, the cells of intervertebral discs are supplied with essential nutrients by diffusion…”
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Effect of nutrient deprivation on the viability of intervertebral disc cells by Bibby, S R S, Urban, J P G

“…There is evidence that a fall in nutrient supply leads to disc degeneration but little understanding of the effects of nutrient deprivation on the physiology…”
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Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute by Motaghinasab, S., Shirazi-Adl, A., Parnianpour, M., Urban, J. P. G.

“…Purpose Tests on animals of different species with large differences in intervertebral disc size are commonly used to investigate the therapeutic efficacy of…”
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Computational pharmacokinetics of solute penetration into human intervertebral discs—Effects of endplate permeability, solute molecular weight and disc size by Motaghinasab, S, Shirazi-Adl, A, Urban, J.P.G, Parnianpour, M

“…Abstract A finite element model is developed to predict the penetration time-history of three different solutes into the human lumbar disc following…”
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Investigation of solute concentrations in a 3D model of intervertebral disc by Mokhbi Soukane, D., Shirazi-Adl, A., Urban, J. P. G.

“…As the disc is the largest avascular structure in the body, disc cells depend for their normal function on an adequate supply of nutrients (oxygen and glucose)…”
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Detection of fiber faults in passive optical networks by Urban, P. J., Getaneh, A., von der Weid, J. P., Temporao, G. P., Vall-llosera, G., Chen, J.

“…Wider deployment of fiber in the last mile is driven by increased customer needs for broadband communication services. This deployment requires solutions that…”
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Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk by Ishihara, H, McNally, D S, Urban, J P, Hall, A C

“…The intervertebral disk is routinely subjected to compressive loads that alter with posture and muscle activity and can produce pressures > 2 MPa in human…”
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Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality by Ishihara, H, Warensjo, K, Roberts, S, Urban, J P

“…Proteoglycans, through their polyelectrolyte properties, regulate the ionic composition and hence the osmotic pressure of the extracellular matrix. We measured…”
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Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes by Urban, J P, Hall, A C, Gehl, K A

“…Chondrocytes in cartilage are embedded in a matrix containing a high concentration of proteoglycans and hence of fixed negative charges. Their extracellular…”
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Delivering Focused Ultrasound to Intervertebral Discs Using Time-Reversal by Qiao, S., Elbes, D., Boubriak, O., Urban, J.P.G, Coussios, C-C., Cleveland, R.O.

“…Chronic low back pain causes more disability worldwide than any other condition and is thought to arise in part through loss of biomechanical function of…”
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Demonstration of a 120° hybrid based simplified coherent receiver on SOI for high speed PON applications by Saber, Md G, Osman, M, Patel, D, Samani, A, El-Fiky, E, Alam, M S, Shahriar, K A, Xing, Z, Jacques, M, Dortschy, B, Vall-Llosera, G, Urban, P J, Cavaliere, F, Lessard, S, Plant, D V

“…We demonstrate the first simplified coherent receiver using a 120° hybrid on silicon-on-insulator (SOI) for high speed PON applications. This coherent receiver…”
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Feasibility of Centralized Passive Optical Network Monitoring Using Passive Optical Network-Tuned Optical Time-Domain Reflectometry by Temporão, G. P., Vilela De Faria, G., Urban, P. J., Von Der Weid, J. P.

“…The increasing deployment of passive optical networks implies an equally increasing need for automatic monitoring systems. This article evaluates the…”
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Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues by Sivan, S.S., Roberts, S., Urban, J.P.G., Menage, J., Bramhill, J., Campbell, D., Franklin, V.J., Lydon, F., Merkher, Y., Maroudas, A., Tighe, B.J.

“…The load-bearing biomechanical role of the intervertebral disc is governed by the composition and organization of its major macromolecular components, collagen…”
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The role of the physicochemical environment in determining disc cell behaviour by Urban, J P G

“…The cells of the intervertebral disc exist in an unusual environment. They are embedded in a dense matrix containing a high concentration of aggrecan whose…”
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Effects of rapid cooling on articular cartilage by Guan, J., Urban, J.P.G., Li, Z.H., Ferguson, D.J.P., Gong, C.Y., Cui, Z.F.

“…In order to improve the technique and protocols of cryopreservation of articular cartilage, a study was carried out to assess the effects of rapid cooling on…”
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The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc by Ohshima, H, Urban, J P

“…The intervertebral disc is the largest avascular tissue in the body. Its metabolism is mainly anaerobic, and thus lactate is produced at a significant rate. As…”
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The effects of hydrostatic pressure on matrix synthesis in articular cartilage by Hall, A C, Urban, J P, Gehl, K A

“…The direct effects of hydrostatic pressure on matrix synthesis in articular cartilage can be studied independently of the other factors that change during…”
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Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc by Roberts, S, Menage, J, Urban, J P

“…The cartilaginous end-plate is thought to play an important role in the nutrition of the intervertebral disc, and hence may be of significance in the etiology…”
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Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells by Wuertz, K., Urban, J.P.G., Klasen, J., Ignatius, A., Wilke, H.-J., Claes, L., Neidlinger-Wilke, C.

“…Intervertebral discs (IVD) have a higher extracellular osmolarity than most other tissues; moreover their osmolarity changes by around 25% during each diurnal…”
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