Search Results - "Urban, Joseph F."
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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Published in Science (American Association for the Advancement of Science) (05-01-2018)“…Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and…”
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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Published in Nature immunology (01-09-2014)“…Alternatively activated (M2) macrophages use fatty acid oxidation for their metabolic needs. Pearce and colleagues show that triacylglycerols metabolized by…”
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Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine
Published in Proceedings of the National Academy of Sciences - PNAS (22-05-2018)“…The hallmark features of type 2 mucosal immunity include intestinal tuft and goblet cell expansion initiated by tuft cell activation. How infectious agents…”
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Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function
Published in Immunity (Cambridge, Mass.) (20-11-2018)“…Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all ILC subsets, but how these cells are balanced to achieve immune…”
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Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality
Published in Cell (19-05-2016)“…Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis and mirror adaptive CD4+ T helper (Th) cell subtypes in both…”
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Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis
Published in Immunity (Cambridge, Mass.) (12-01-2021)“…The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to…”
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Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion
Published in Nature immunology (01-10-2014)“…The role of neutrophils in helminth infection has been relatively unclear. Gause and colleagues demonstrate that neutrophils are involved in the priming of an…”
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Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection
Published in The Journal of experimental medicine (25-07-2016)“…Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little…”
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Protective immune mechanisms in helminth infection
Published in Nature reviews. Immunology (01-12-2007)“…Important insights have recently been gained in our understanding of how host immune responses mediate resistance to parasitic helminths and control associated…”
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IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells
Published in Nature immunology (01-02-2015)“…Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through…”
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Crosstalk between ILC2s and Th2 cells varies among mouse models
Published in Cell reports (Cambridge) (28-02-2023)“…Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses…”
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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis
Published in Cell (04-03-2021)“…Although enteric helminth infections modulate immunity to mucosal pathogens, their effects on systemic microbes remain less established. Here, we observe…”
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The porcine translational research database: a manually curated, genomics and proteomics-based research resource
Published in BMC genomics (22-08-2017)“…The use of swine in biomedical research has increased dramatically in the last decade. Diverse genomic- and proteomic databases have been developed to…”
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Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis
Published in Infection and Immunity (01-06-2012)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
Published in Nature medicine (01-08-2006)“…Although primary and memory responses against bacteria and viruses have been studied extensively, T helper type 2 (TH2) effector mechanisms leading to host…”
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Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models
Published in Microbiome (04-06-2020)“…The anti-inflammatory property of ω-3 polyunsaturated fatty acids (PUFA) has been exploited in the management of inflammatory bowel disease (IBD) with…”
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Flavanol-Enriched Cocoa Powder Alters the Intestinal Microbiota, Tissue and Fluid Metabolite Profiles, and Intestinal Gene Expression in Pigs
Published in The Journal of nutrition (01-04-2016)“…Consumption of cocoa-derived polyphenols has been associated with several health benefits; however, their effects on the intestinal microbiome and related…”
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Alternatively activated macrophages in helminth infections
Published in Current Opinion in Immunology (01-08-2007)“…Helminthic parasites can trigger highly polarized immune responses typically associated with increased numbers of CD4+ Th2 cells, eosinophils, mast cells, and…”
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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
Published in Immunity (Cambridge, Mass.) (15-10-2019)“…Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling…”
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Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity
Published in Nature immunology (01-06-2019)“…Most tissue-resident macrophage populations develop during embryogenesis, self-renew in the steady state and expand during type 2 immunity. Whether shared…”
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